Yıl: 2022 Cilt: 30 Sayı: 4 Sayfa Aralığı: 232 - 239 Metin Dili: İngilizce DOI: 10.54875/jarss.2022.83713 İndeks Tarihi: 02-11-2022

Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?

Öz:
Mechanical power (MP) is the amount of energy transferred to the respiratory system of patients during each breath period. After overcoming the resistances required for respiration, the remaining energy may end up by damaging the lung parenchyma. The MP limit that should not be exceeded in pediatric patients is not yet clear. The aim of this observational descriptive study is to compare the perioperative MP measurements in healthy pediatric cases with the values given in the literature. Methods: Perioperative MP was calculated according to the simplified MP formula in pediatric patients without known lung disease and compared with the literature. Results: The mean age of 34 patients was 68.88±31.4 months and the mean weight was 21.82±7.5 kg. The mean MP was 3.93±1.1 J min-1, and the indexed MP was 0.19±0.08 J min-1 kg-1. Both MP (p=0.008) and indexed MP (p<0.001) were significantly higher in patients with high tidal volume. In addition, we found a negative correlation between indexed MP and weight (r: -668 and p<0.001). Both MP and indexed MP had sufficient predictive power to predict tidal volume >10 and predictive value was significant [Auc: 0.764, 95%CI: 0.55-0.97, p: 0.026]. The value of MP>3.76 was an indicator for tidal volume >10 with 87 sensitivity and 50 specificity. Predictive value of indexed MP for tidal volume >10 mL kg-1 was 0.25 J kg-1 [AUC 0.856, 95%CI: 0.70-1.0, p=0.003], and indexed MP was a stronger indicator than MP. Conclusion: This study revealed that MP threshold values calculated for adults or patients with ARDS lung are not sensitive for pediatric patients, and a new threshold value should be determined for these patients.
Anahtar Kelime:

Pediyatrik Hastalarda Güvenlik Önlemi Olarak Mekanik Güç Kullanılabilir mi?

Öz:
Mekanik güç (MP), her nefes döngüsünde hastaların solunum sistemine aktarılan enerji miktarıdır. Solunum için gerekli olan dirençler aşıldıktan sonra kalan enerji akciğer parankimine zarar vererek sonlanabilir. Pediatrik hastalarda aşılmaması gereken MP sınırı henüz netlik kazanmamıştır. Bu gözlemsel tanımlayıcı çalışmanın amacı, sağlıklı pediatrik olgularda perioperatif MP ölçümlerini literatürde verilen değerlerle karşılaştırmaktır. Yöntem: Perioperatif MP, bilinen akciğer hastalığı olmayan pediatrik hastalarda basitleştirilmiş MP formülüne göre hesaplandı ve literatürle karşılaştırıldı. Bulgular: 34 hastanın yaş ortalaması 68.88±31.4 ay ve ortalama ağırlık 21.82±7.5 kg idi. Ortalama MP 3,93±1,1 J dak-1 ve indekslenmiş MP 0,19±0,08 J dak-1 kg-1 idi. Hem MP (p=0,008) hem de indekslenmiş MP (p<0,001) tidal hacmi yüksek olan hastalarda anlamlı olarak daha yüksekti. Ayrıca indekslenen MP ile ağırlık (r: -668 ve p<0.001) arasında negatif korelasyon bulduk. Hem MP hem de indekslenmiş MP, tidal hacmi >10 tahmin etmek için yeterli tahmin gücüne sahipti ve tahmin değeri anlamlıydı [Auc: 0.764, %95 CI: 0.55-0.97, p: 0.026]. MP>3.76 değeri, 87 duyarlılık ve 50 özgüllük ile >10 tidal hacim için bir göstergeydi. >10 mL kg-1 tidal hacim için indekslenmiş MP’nin tahmin değeri 0.25 J kg-1 [AUC 0.856, %95 CI: 0.70-1.0, p=0.003] idi ve indekslenmiş MP, MP’den daha güçlü bir gösterge idi. Sonuç: Bu çalışma, yetişkinler veya ARDS akciğeri olan hastalar için hesaplanan MP eşik değerlerinin çocuk hastalar için hassas olmadığını ve bu hastalar için yeni bir eşik değerinin belirlenmesi gerektiğini ortaya koymuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Giosa L, Busana M, Pasticci I, et al. Mechanical power at a glance: A simple surrogate for volume-controlled ventilation. Intensive Care Med Exp 2019;7(1):61.
  • 2. Gattinoni L, Tonetti T, Cressoni M, et al. Ventilator-related causes of lung injury: The mechanical power. Intensive Care Med 2016;42(10):1567-75.
  • 3. Kronen RJ, Banner-Goodspeed V, Talmor DS, Beitler JR, Schaefer MS, Baedorf Kassis E. Mechanical power and ventilator-free survival in mechanically ventilated patients with ARDS. Am J Respir Crit Care Med. 2021;203:A2758.
  • 4. Serpa Neto A, Deliberato RO, Johnson AEW, et al. Mechanical power of ventilation is associated with mortality in critically ill patients: An analysis of patients in two observational cohorts. Intensive Care Med 2018;44(11):1914-22.
  • 5. Cressoni M, Gotti M, Chiurazzi C, et al. Mechanical power and development of ventilator-induced lung injury. Anesthesiology 2016;124(5):1100-8.
  • 6. Costa ELV, Slutsky AS, Brochard LJ, et al. Ventilatory variables and mechanical power in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2021;204(3):303-11.
  • 7. Costa ELV, Slutsky AS, Amato MBP. Reply to Camporota et al.: The 4DPRR index and mechanical power: A step ahead or 4 steps backward? Am J Respir Crit Care Med 2021;204(4):492- 3.
  • 8. Parhar KKS, Zjadewicz K, Soo A, et al. Epidemiology, mechanical power, and 3-year outcomes in acute respiratory distress syndrome patients using standardized screening: An observational cohort study. Ann Am Thorac Soc 2019;16(10):1263-72.
  • 9. Marini JJ, Rocco PRM. Which component of mechanical power is most important in causing VILI? Crit Care 2020;24(1):39.
  • 10. Collino F, Rapetti F, Vasques F, et al. Positive endexpiratory pressure and mechanical power. Anesthesiology 2019;130(1):119-30.
  • 11. Becher T, van der Staay M, Schädler D, Frerichs I, Weiler N. Calculation of mechanical power for pressure-controlled ventilation. Intensive Care Med 2019;45(9):1321-3.
  • 12. van der Meijden S, Molenaar M, Somhorst P, Schoe A. Calculating mechanical power for pressure-controlled ventilation. Intensive Care Med 2019;45(10):1495-7.
  • 13. Díaz F, González-Dambrauskas S, Cristiani F, Casanova DR, Cruces P. Driving pressure and normalized energy transmission calculations in mechanically ventilated children without lung disease and pediatric acute respiratory distress syndrome. Pediatr Crit Care Med 2021;22(10):870-8.
  • 14. Amato MB, Barbas CS, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998;338(6):347- 54.
  • 15. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342(18):1301-8.
  • 16. Huhle R, Serpa Neto A, Schultz MJ, Gama de Abreu M. Is mechanical power the final word on ventilator-induced lung injury?-no. Ann Transl Med 2018;6(19):394.
  • 17. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009;151(8):566-76.
  • 18. Terragni PP, Del Sorbo L, Mascia L, et al. Tidal volume lower than 6 ml/kg enhances lung protection. Anesthesiology 2009;111(4):826-35.
  • 19. Canet J, Gallart L, Gomar C, et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology 2010;113(6):1338-50.
  • 20. Protti A, Votta E, Gattinoni L. Which is the most important strain in the pathogenesis of ventilator-induced lung injury. Curr Opin Crit Care 2014;20(1):33-8.
  • 21. Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators, Cavalcanti AB, Suzumura ÉA, Laranjeira LN, et al. Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome. JAMA 2017;318(14):1335-45.
  • 22. Yüksek A, Bakı ED, Sarıtaş TB, Sıvacı R. A comparison of the effects of lung protective ventilation and conventional ventilation on thermoregulation during anaesthesia. Turk J Anaesthesiol Reanim 2019;47(3):173-8.
  • 23. Gattinoni L, Tonetti T, Quintel M. Intensive care medicine in 2050: Ventilator-induced lung injury. Intensive Care Med 2018;44(1):76-8.
  • 24. Gattinoni L, Marini JJ, Collino F, et al. The future of mechanical ventilation: Lessons from the present and the past. Crit Care 2017;21(1):1-11.
  • 25. Rauf A, Sachdev A, Venkataraman ST, Dinand V. Dynamic airway driving pressure and outcomes in children with acute hypoxemic respiratory failure. Respir Care 2021;66(3):403-9.
  • 26. Tonna JE, Peltan I, Brown SM, et al. Mechanical power and driving pressure as predictors of mortality among patients with ARDS. Intensive Care Med 2020;46(10):1941-3.
  • 27. Senzi A, Bindi M, Cappellini I, Zamidei L, Consales G. COVID-19 and VILI: Developing a mobile app for measurement of mechanical power at a glance. Intensive Care Med Exp 2021;9(1):6.
  • 28. Xie Y, Liu S, Mou Z, Wang Y, Li X. Correlation analysis between mechanical power and lung ultrasound score and their evaluation of severity and prognosis in ARDS patients. Biomed Res Int 2021;2021:4156162.
APA yüksek a, Miniksar Ö, YARDIMCI C, A (2022). Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. , 232 - 239. 10.54875/jarss.2022.83713
Chicago yüksek ahmet,Miniksar Ökkeş Hakan,YARDIMCI CEVDET, AYŞEGÜL Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. (2022): 232 - 239. 10.54875/jarss.2022.83713
MLA yüksek ahmet,Miniksar Ökkeş Hakan,YARDIMCI CEVDET, AYŞEGÜL Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. , 2022, ss.232 - 239. 10.54875/jarss.2022.83713
AMA yüksek a,Miniksar Ö,YARDIMCI C, A Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. . 2022; 232 - 239. 10.54875/jarss.2022.83713
Vancouver yüksek a,Miniksar Ö,YARDIMCI C, A Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. . 2022; 232 - 239. 10.54875/jarss.2022.83713
IEEE yüksek a,Miniksar Ö,YARDIMCI C, A "Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?." , ss.232 - 239, 2022. 10.54875/jarss.2022.83713
ISNAD yüksek, ahmet vd. "Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?". (2022), 232-239. https://doi.org/10.54875/jarss.2022.83713
APA yüksek a, Miniksar Ö, YARDIMCI C, A (2022). Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. Anestezi Dergisi, 30(4), 232 - 239. 10.54875/jarss.2022.83713
Chicago yüksek ahmet,Miniksar Ökkeş Hakan,YARDIMCI CEVDET, AYŞEGÜL Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. Anestezi Dergisi 30, no.4 (2022): 232 - 239. 10.54875/jarss.2022.83713
MLA yüksek ahmet,Miniksar Ökkeş Hakan,YARDIMCI CEVDET, AYŞEGÜL Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. Anestezi Dergisi, vol.30, no.4, 2022, ss.232 - 239. 10.54875/jarss.2022.83713
AMA yüksek a,Miniksar Ö,YARDIMCI C, A Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. Anestezi Dergisi. 2022; 30(4): 232 - 239. 10.54875/jarss.2022.83713
Vancouver yüksek a,Miniksar Ö,YARDIMCI C, A Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?. Anestezi Dergisi. 2022; 30(4): 232 - 239. 10.54875/jarss.2022.83713
IEEE yüksek a,Miniksar Ö,YARDIMCI C, A "Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?." Anestezi Dergisi, 30, ss.232 - 239, 2022. 10.54875/jarss.2022.83713
ISNAD yüksek, ahmet vd. "Can Mechanical Power be Used as a Safety Precaution in Pediatric Patients?". Anestezi Dergisi 30/4 (2022), 232-239. https://doi.org/10.54875/jarss.2022.83713