VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality

Longato, Adhemar; Pereira, In s S; Martins, Sandra F; Santos, Pedro Miguel Dias dos

doi:10.14744/ejmo.2022.88799

VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality

Pedro Miguel Dias dos Santos, (General Surgery Resident, Torres Vedras’s Hospital, Internship in General Surgery at Braga’s Hospital, Portugal)

In s S Pereira, (Faculty of Medicine, University of Minho, Braga, Portugal)

Adhemar Longato, (Life and Health Science Research Institute (ICVS), Faculty of Medicine, University of Minho, Braga, Portugal)

Sandra F Martins (Life and Health Science Research Institute (ICVS), Faculty of Medicine, University of Minho, Braga, Portugal)

Eurasian Journal of Medicine and Oncology

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Yıl: 2022 Cilt: 6 Sayı: 3 Sayfa Aralığı: 258 - 267 Metin Dili: İngilizce DOI: 10.14744/ejmo.2022.88799 İndeks Tarihi: 03-11-2022

VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality

Öz:

Objectives: Colorectal cancer is the most frequent and mortal cancer in Portugal. Both angiogenesis and cellular prolif- eration are core mechanisms to tumoral progression, with VEGF (Vascular Endothelial Growth Factor) and Ki-67, respec- tively, being widely known markers of those two processes. The purposes of this study are to comprehend VEGF and Ki-67’s impact on colorectal cancer prognosis which include assessing its expression in primary colorectal cancer of pa- tients who underwent surgery, establishing associations between the expression of VEGF and Ki-67 and discovering hy- pothetical associations between these biomarkers and clinicopathological aspects, relapse, and mortality of patients. Methods: A retrospective study was conducted in our hospital by including 512 patients submitted to surgery, from 2005 to 2010, with a post-operatory diagnosis of colorectal adenocarcinoma. The evaluation of expression of VEGF and Ki-67 in the obtained tissue was made through immunohistochemistry technique. The statistical analysis resourced to association tests and survival analysis. Results: VEGF-A showed association with the variable gender (p-value of 0.016), with its expression being more fre- quent in men. VEGF-C expression is more common in colon than in rectum (p- value of 0.042). VEGF-C is significantly associated with Ki-67 (p-value of 0.036), with 69.7% of cases where both are positive. All markers are significantly as- sociated with the grade of differentiation, with the VEGF family generally more present in well or moderately differenti- ated tumours and Ki-67 in the poorly differentiated. While the survival time was generally lower in the presence of any marker or combination, no significant differences were found among the survival analysis. Conclusion: VEGF-A, VEGF-C and Ki-67 expression did not show impact on the prognosis of this sample of patients. There was no significant association with a poorer overall survival or a reduced disease-free survival.

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APA	Santos P, Pereira I, Longato A, Martins S (2022). VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. , 258 - 267. 10.14744/ejmo.2022.88799
Chicago	Santos Pedro Miguel Dias dos,Pereira In s S,Longato Adhemar,Martins Sandra F VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. (2022): 258 - 267. 10.14744/ejmo.2022.88799
MLA	Santos Pedro Miguel Dias dos,Pereira In s S,Longato Adhemar,Martins Sandra F VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. , 2022, ss.258 - 267. 10.14744/ejmo.2022.88799
AMA	Santos P,Pereira I,Longato A,Martins S VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. . 2022; 258 - 267. 10.14744/ejmo.2022.88799
Vancouver	Santos P,Pereira I,Longato A,Martins S VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. . 2022; 258 - 267. 10.14744/ejmo.2022.88799
IEEE	Santos P,Pereira I,Longato A,Martins S "VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality." , ss.258 - 267, 2022. 10.14744/ejmo.2022.88799
ISNAD	Santos, Pedro Miguel Dias dos vd. "VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality". (2022), 258-267. https://doi.org/10.14744/ejmo.2022.88799

APA	Santos P, Pereira I, Longato A, Martins S (2022). VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. Eurasian Journal of Medicine and Oncology, 6(3), 258 - 267. 10.14744/ejmo.2022.88799
Chicago	Santos Pedro Miguel Dias dos,Pereira In s S,Longato Adhemar,Martins Sandra F VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. Eurasian Journal of Medicine and Oncology 6, no.3 (2022): 258 - 267. 10.14744/ejmo.2022.88799
MLA	Santos Pedro Miguel Dias dos,Pereira In s S,Longato Adhemar,Martins Sandra F VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. Eurasian Journal of Medicine and Oncology, vol.6, no.3, 2022, ss.258 - 267. 10.14744/ejmo.2022.88799
AMA	Santos P,Pereira I,Longato A,Martins S VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. Eurasian Journal of Medicine and Oncology. 2022; 6(3): 258 - 267. 10.14744/ejmo.2022.88799
Vancouver	Santos P,Pereira I,Longato A,Martins S VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality. Eurasian Journal of Medicine and Oncology. 2022; 6(3): 258 - 267. 10.14744/ejmo.2022.88799
IEEE	Santos P,Pereira I,Longato A,Martins S "VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality." Eurasian Journal of Medicine and Oncology, 6, ss.258 - 267, 2022. 10.14744/ejmo.2022.88799
ISNAD	Santos, Pedro Miguel Dias dos vd. "VEGF and Ki-67 Expression in Colorectal Cancer: The Long-Term Impact on Recurrence and Mortality". Eurasian Journal of Medicine and Oncology 6/3 (2022), 258-267. https://doi.org/10.14744/ejmo.2022.88799