Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis

erbaş, oytun; Yigitturk, Gurkan; ÇAKIR, Adem; Erdogan, Arife; Bora, Ejder Saylav; Erdogan, Mumin

doi:10.14744/tjtes.2020.02589

Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis

Ejder Saylav Bora, (İzmir Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Anabilim Dalı, İzmir, Türkiye)

Arife Erdoğan, (İzmir Çiğli Bölge Eğitim Hastanesi Acil Tıp Anabilim Dalı, İzmir, Türkiye)

MÜMİN ALPER ERDOĞAN, (izmir Katip Çelebi Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, İzmir)

Gürkan YİĞİTTÜRK, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Muğla,Türkiye)

Adem Çakır, (İzmir Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Anabilim Dalı, İzmir, Türkiye)

Oytun Erbaş (istanbul Demiroğlu Bilim Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, İstanbul,Türkiye)

Ulusal Travma ve Acil Cerrahi Dergisi

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Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 8 - 14 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.02589 İndeks Tarihi: 03-11-2022

Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis

Öz:

BACKGROUND: Acute respiratory distress syndrome is a devastating complication of severe sepsis. Preclinical models suggest that direct lung injury begins with attack to the lung epithelium, but indirect lung injury results from systemic endothelial damage due to inflammatory mediators. The aim of the present study was to explore the effect of octreotide on lungs in a surgically induced sepsis model in rats. METHODS: We used 32 male Sprague Dawley rats and divided into four groups. Group 1: Normal (non-operative and orally fed control, n=8); Group 2: Sham operated (n=8); Group 3: Cecal ligation and puncture (CLP) (untreated group, n=8); and Group 4: CLP and 100 μg/kg octreotide i.p. (n=8). For sepsis, CLP procedure was performed on 16 rats to induce a sepsis model. All groups were analyzed, their blood was taken for arterial blood gas analysis. For histological examination, lung tissues were removed and sections were prepared. RESULTS: In histological examination, if we compare CLP + Octreotide with only CLP group in CLP + Octreotide group decreased inflammatory cell infiltration in alveolar and interstitial area as well as edema, bleeding, when CLP group was compared with oct- reotide group, all histopathological parameters improved significantly and the severity index decreased from 3 to 1. For arterial blood gas, when CLP and octreotide groups were compared with CLP group, it was observed that there was a significant change in favor of healing and that they almost came up to controls and sham group. CONCLUSION: It could be hypothesized that it would be beneficial to administer octreotide for ameliorate lung injury state in sepsis patients.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	Bora E, Erdogan A, Erdogan M, Yigitturk G, ÇAKIR A, erbaş o (2022). Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. , 8 - 14. 10.14744/tjtes.2020.02589
Chicago	Bora Ejder Saylav,Erdogan Arife,Erdogan Mumin,Yigitturk Gurkan,ÇAKIR Adem,erbaş oytun Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. (2022): 8 - 14. 10.14744/tjtes.2020.02589
MLA	Bora Ejder Saylav,Erdogan Arife,Erdogan Mumin,Yigitturk Gurkan,ÇAKIR Adem,erbaş oytun Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. , 2022, ss.8 - 14. 10.14744/tjtes.2020.02589
AMA	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. . 2022; 8 - 14. 10.14744/tjtes.2020.02589
Vancouver	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. . 2022; 8 - 14. 10.14744/tjtes.2020.02589
IEEE	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o "Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis." , ss.8 - 14, 2022. 10.14744/tjtes.2020.02589
ISNAD	Bora, Ejder Saylav vd. "Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis". (2022), 8-14. https://doi.org/10.14744/tjtes.2020.02589

APA	Bora E, Erdogan A, Erdogan M, Yigitturk G, ÇAKIR A, erbaş o (2022). Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. Ulusal Travma ve Acil Cerrahi Dergisi, 28(1), 8 - 14. 10.14744/tjtes.2020.02589
Chicago	Bora Ejder Saylav,Erdogan Arife,Erdogan Mumin,Yigitturk Gurkan,ÇAKIR Adem,erbaş oytun Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. Ulusal Travma ve Acil Cerrahi Dergisi 28, no.1 (2022): 8 - 14. 10.14744/tjtes.2020.02589
MLA	Bora Ejder Saylav,Erdogan Arife,Erdogan Mumin,Yigitturk Gurkan,ÇAKIR Adem,erbaş oytun Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. Ulusal Travma ve Acil Cerrahi Dergisi, vol.28, no.1, 2022, ss.8 - 14. 10.14744/tjtes.2020.02589
AMA	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. Ulusal Travma ve Acil Cerrahi Dergisi. 2022; 28(1): 8 - 14. 10.14744/tjtes.2020.02589
Vancouver	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis. Ulusal Travma ve Acil Cerrahi Dergisi. 2022; 28(1): 8 - 14. 10.14744/tjtes.2020.02589
IEEE	Bora E,Erdogan A,Erdogan M,Yigitturk G,ÇAKIR A,erbaş o "Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis." Ulusal Travma ve Acil Cerrahi Dergisi, 28, ss.8 - 14, 2022. 10.14744/tjtes.2020.02589
ISNAD	Bora, Ejder Saylav vd. "Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis". Ulusal Travma ve Acil Cerrahi Dergisi 28/1 (2022), 8-14. https://doi.org/10.14744/tjtes.2020.02589