TY  - JOUR
TI  - Lipid Emulsion Treatment in Tricyclic Antidepressant Poisoning in Children: An Observational Cohort Study
AB  - Tricyclic  antidepressant  (TCA)  poisonings  are  among  the  most  common  childhood  poisonings  because  of  being  cheap  and  readily  available.  In  this  manuscript,  we  aimed  to  share  our  experience  with  Intravenous  lipid  emulsions  (ILE)  treatment  in  addition to basic treatment steps and discussion of effectiveness of treatment in cases of poisoning caused by high-dose TCA intake. From the patients under 18 years of  age  who  admitted  to  Pediatric  Emergency  Department  due  to  drug  intoxication  between January 2014 and December 2019; those who had history of exposure to TCAs  were  included  in  our  study.  In  conclusion  of  examination  of  six-year  patient  records, it was determined that there were a total of 619 intoxication cases and 108 (17.4%)  of  these  were  TCA  poisoning.  21  (19.4%)  patients  who  had  hypotension,  tachycardia  and  ECG  changes  which  were  refractory  to  all  basic  treatment  steps  were administered ILE.  After ILE treatment, a marked improvement was observed in patients’ clinical and ECG findings, as well as vital signs. Early administration of ILE  treatment  in  emergency  departments  for  cases  with  hypotension,  conduction  disorder, dysrhythmia or widened QRS which are refractory to sodium bicarbonate is thought to prevent potential cardiovascular complications
AU  - türe, esra
AU  - Akin, Fatih
AU  - Kılıç, Ahmet Osman
AU  - Yazar, Abdullah
DO  - 10.51271/jpea-2021-0113
PY  - 2021
JO  - The journal of pediatric academy (Online)
VL  - 2
IS  - 1
SN  - 2718-0875
SP  - 14
EP  - 17
DB  - TRDizin
UR  - http://search/yayin/detay/1137445
ER  -