TY  - JOUR
TI  - Bladder granulocytic sarcoma in a child: case report and literature review
AB  - Background. Granulocytic sarcoma (GS) is an extramedullary solid tumor composed of immature myeloid cells. GS has been associated with acute myeloid leukemia (AML), myelodysplastic syndromes or myeloproliferative diseases. Although GS can affect various tissues of the human body, it has rarely been reported in other soft tissues such as the breast, gastrointestinal, respiratory and genitourinary tracts. We report a pediatric case diagnosed with granulocytic sarcoma of the bladder and concomitant AML. Case. A twelve-year-old previously healthy girl was admitted to the pediatric urology clinic with a ten-day history of hematuria and pollakiuria. Laboratory examinations revealed anemia, thrombocytopenia and neutrophilic leukocytosis. Bone marrow aspiration results were consistent with acute myeloid leukemia -FAB subtype M2-. Abdominal magnetic resonance imaging (MRI) showed an irregularly bounded 12 cm mass on the right side of the bladder. Transurethral resection (TUR) pathology was consistent with granulocytic sarcoma. After a multimodal treatment approach, complete remission was achieved. Conclusions. Malignant bladder masses are rare causes of macroscopic hematuria in childhood. The diagnostic spectrum is wide, ranging from rhabdomyosarcoma to leukemia involvement. The bladder is a rare site of extramedullary involvement in pediatric patients with AML. Multimodal treatment should be considered on a per-patient basis.
AU  - Karaman, Serap
AU  - Oktar, Tayfun
AU  - ÇAKI KILIÇ, SUAR
AU  - İRİBAŞ ÇELİK, AYÇA
AU  - Tugcu, Deniz
AU  - Tuna Deveci, Rumeysa
AU  - Dogan, Ibrahim Oner
AU  - Ince bayramoglu, zuhal
AU  - Anak, Seniye Sema
AU  - KARAKAS, ZEYNEP
AU  - Unuvar, Aysegul
DO  - 10.24953/turkjped.2020.275
PY  - 2022
JO  - Turkish Journal of Pediatrics
VL  - 64
IS  - 1
SN  - 0041-4301
SP  - 152
EP  - 159
DB  - TRDizin
UR  - http://search/yayin/detay/1138613
ER  -