TY  - JOUR
TI  - Novel (p-Tolyl)-3(2H)-Pyridazinone Derivatives Containing Substituted-1,2,3-Triazole Moiety as New AntiAlzheimer Agents: Synthesis, In vitro and In silico Assays
AB  - Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is the most common cause of dementia. The risk of developing the disease increases with age. When the histopathology of the disease is examined, senile amyloid plaques, neurofibrillary tangle formation, synapse-neuron loss, and marked atrophy in the brain are detected. The decrease in the level of choline acetyltransferase, which is responsible for the synthesis of acetylcholine in Alzheimer’s disease, is 58-90%. There is a great need for new drugs that target the basis of the cause of the disease, as existing drugs cannot stop the progression of the disease. In this study, triazole-pyridazinone derivative compounds showing acetylcholinesterase inhibition were synthesized and their inhibitions were investigated. Compound 6e exhibited the strongest inhibitory effect with a Ki value of 0.049 ± 0.014 µM (Tacrine Ki= 0.226 ± 0.025 µM). In addition, in silico studies were applied for all compounds.
AU  - TÜRKMENOĞLU, BURÇİN
AU  - Taşkor Önel, Gülce
AU  - GÜRSOY, ŞULE
AU  - Dilek, Esra
AU  - Bozbey Merde, İrem
DO  - 10.55262/fabadeczacilik.1128446
PY  - 2022
JO  - FABAD Journal of Pharmaceutical Sciences
VL  - 47
IS  - 3
SN  - 1300-4182
SP  - 355
EP  - 368
DB  - TRDizin
UR  - http://search/yayin/detay/1140436
ER  -