TY  - JOUR
TI  - Bacteriological Profile and Antimicrobial Resistance Pattern Among Healthcare-Associated Infections in a Pediatric Intensive Care Unit
AB  - Healthcare-associated  infections  (HAIs)  are  a  global  public  health  issue  with  clinical  and  socioeconomic  consequences.  These  infections  are  important  indices  for  the  quality  of  healthcare  services  which  are  serious  complications that should be addressed in pediatric intensive care units (PICUs).  This study aimed to retrospectively examine  the  bacterial  HAIs,  the  frequency  of  isolated  pathogen  microorganisms,  the  areas  of  infection,  and  the  antibiotic susceptibility recorded in the surveillance system in our Pediatric Intensive Care Unit in five years between 01.01.2015 and 31.12.2019. In the study period, 1593 patients were admitted to PICU, and 244 HAIs were detected in 141 patients. A bacterial pathogen was isolated in 190 HAIs of the 99 patients. In those episodes, Gram-negative microorganisms were most commonly seen (160/190). Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella  spp.  were  the  most  common  bacteria.  Enterococcus  spp.  and  coagulase-negative  staphylococci  were  the most common Gram-positive microorganisms. The mortality rate of a bacterial HAI was 40.4%. There was no resistance against vancomycin in Gram-positive microorganisms. The resistance rate against methicillin was 100% in coagulase-negative staphylococci and 50% in S. aureus strains. The cumulative rate of carbapenem resistance was found as 76.1% in Pseudomonas aeruginosa, 45.2% in Klebsiella spp. and 0% in Escherichia coli. In 2019, the resistance rate against colistin in Klebsiella spp. and Pseudomonas aeruginosa were 46.2% (6/13) and 20% (1/5), respectively. The resistance rate against carbapenem and colistin was 81.1% and 0% in Acinetobacter baumannii. It was observed that the use of carbapenem before an infection episode increased significantly, and the rate of carbapenem resistance reached 100% over the years in Pseudomonas aeruginosa and Klebsiella spp. A significant proportion of the isolates were multidrug-resistant strains, significantly threatening survival. Implementation of effective preventive strategies to combat the emergence of antibiotic resistance is urgently needed.
AU  - Kürkçü, Cemile Altay
AU  - KÜÇÜK, Fatma
AU  - Akyıldız, Basak Nur
AU  - Cetin, Benhur
AU  - Şahin, Ayşegül
AU  - Sağıroğlu, Pınar
DO  - 10.51271/jpea-2022-189
PY  - 2022
JO  - The journal of pediatric academy (Online)
VL  - 3
IS  - 2
SN  - 2718-0875
SP  - 78
EP  - 84
DB  - TRDizin
UR  - http://search/yayin/detay/1140710
ER  -