Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration
Yıl: 2022 Cilt: 46 Sayı: 5 Sayfa Aralığı: 388 - 399 Metin Dili: İngilizce DOI: 10.55730/1300-0152.2625 İndeks Tarihi: 05-12-2022
Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration
Öz: Neurodegeneration is the progressive loss of structure or function of neurons. Amyloid beta oligomers and aggregates have been linked to neurodegeneration. While previous studies have suggested that dietary α-tocopherol intake can prevent amyloid beta aggregation and protect the brain against neurotoxicity, other research, however, indicated that tocotrienol forms might be used as an alternate agent against this kind of degeneration. In the presented research, we compared the in vitro protective effects of α-tocopherol and α-tocotrienol. In this context, we formed an in vitro neurodegeneration model with primary isolated neurons and measured α-tocopherol’s and α-tocotrienol’s protective effects. As a result, α-tocopherol and α-tocotrienol prevent the degeneration of neurons. Moreover, α-tocopherol and α-tocotrienol regulated the neuron’s calcium channels mechanism by decreasing the expression of the calcium channel alpha 1C subunit. We also observed that the amount of amyloid beta accumulation in the extracellular matrix decreased with the application of these isoforms. In specific time points, α-tocopherol and α-tocotrienol differ in terms of protective effects. In conclusion, it could be interpreted that, in more extended periods, α-tocotrienol could be a significant protective agent against amyloid beta-induced neurodegeneration, and it can be used as an alternative to other protective agents, especially α-tocopherol.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Abdel Wahab SI, Abdul AB, Alzubairi AS, Elhassan MM, Mohan S (2009). In Vitro Ultramorphological Assessment of Apoptosis Induced by Zerumbone on (HeLa). BioMed Research International 2009: 769568. doi: 10.1155/2009/769568
- Berridge MJ (2010). Calcium hypothesis of Alzheimer’s disease. Signaling and Cell Physiology 459 (3): 441-449. doi: 10.1007/ s00424-009-0736-1
- Bhat S, Dao DT, Terrillion CE, Arad M, Smith RJ et al. (2012). CACNA1c (Cav1.2) in the pathophysiology of psychiatric disease. Progress in Neurobiology 99 (1): 1-14. doi: 10.1016/j. pneurobio.2012.06.001
- Canevari L, Abramov AY, Duchen MR (2004). Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress. Neurochemical Research 29 (3): 637-650. doi: 10.1023/b:nere.0000014834.06405.af
- Chang KH, Cheng ML, Chen CM, Chiang MC (2018). Lipophilic antioxidants in neurodegenerative diseases. Clinica Chimica Acta 485: 79-87. doi: 10.1016/j.cca.2018.06.031
- Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, et al. (2017). Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacologica Sinica 38 (9): 1205-1235. doi: 10.1038/aps.2017.28
- Choi K, Kim J, Kim G, Choi C (2009). Oxidative stress-induced necrotic cell death via mitochondria-dependent burst of reactive oxygen species. Current Neurovascular Research 6 (4): 213-22. doi: 10.2174/156720209789630375
- Ciapetti G, Granchi D, Savarino L, Cenni E, Magrini E et al. (2002). In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells. Biomaterials. 23 (2): 617-627. doi: 10.1016/s0142-9612(01)00149-1
- Crouzin N, de Jesus Ferreira MC, Cohen-Solal C, Aimar RF, Vignes M et al. (2007). Alpha-tocopherol-mediated long-lasting protection against oxidative damage involves an attenuation of calcium entry through TRP-like channels in cultured hippocampal neurons. Free Radical Biology & Medicine. 42 (9): 1326-37. doi: 10.1016/j.freeradbiomed.2007.01.032
- Das B, Yan R (2017). Role of BACE1 in Alzheimer’s synaptic function. Translational Neurodegeneration 6 (30). doi: 10.1186/s40035- 017-0093-5
- Durukan AB, Akbay E, Ünlü A, Özdemir A, Onur MA (2019). The cytotoxic properties and apoptotic potential of N-butyl and 2-octyl cyanoacrylates used in surgical treatment of chronic venous insufficiency. Turkish Journal of Thoracic and Cardiovascular Surgery 27 (2): 185-191. doi: 10.5606/tgkdc. dergisi.2019.17091
- Grimm MO, Mett J, Hartmann T (2016). The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer ́s Disease. International Journal of Molecular Sciences 17 (11): 1785. doi: 10.3390/ijms17111785
- Grimm MO, Regner L, Stahlmann CP, Schorr P, Nelke C et al. (2016). Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease. International Journal of Molecular Sciences 17 (11): 1809. doi: 10.3390/ijms17111809
- Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC et al. (2005). Vitamin E: Curse or Benefit in Alzheimer’s Disease? A Systematic Investigation of the Impact of alpha-, gamma- and delta-Tocopherol on Aβ Generation and Degradation in Neuroblastoma Cells. the Journal of Nutrition, Health & Aging 19 (6): 646-656. doi: 10.1007/s12603-015-0506-z
- Goedert M (2007). Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies. In: Schapira, A, Wszolek Z, Dawson TM, Wood N (editors). Neurodegeneration Oxford. John Wiley and Sons pp. 12-25. doi: 10.1016/j. neurol.2016.05.002
- Gugliandolo A, Bramanti P, Mazzon E (2017). Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models. International Journal of Molecular Sciences 18 (12): 2504. doi: 10.3390/ijms18122504
- Gugliandolo A, Chiricosta L, Silvestro S, Bramanti P, Mazzon E (2019). alpha-Tocopherol Modulates Non-Amyloidogenic Pathway and Autophagy in an In Vitro Model of Alzheimer’s Disease: A Transcriptional Study. Brain Sciences 9 (8): 196. doi: 10.3390/brainsci9080196
- Hoeijmakers JH (2009). DNA damage, aging, and cancer. The New England Journal of Medicine 361 (15): 1475-1485. doi: 10.1056/NEJMra0804615
- Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE et al. (1999). The Aβ peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 38 (24): 7609-7616. doi: 10.1021/bi990438f
- Ibrahim NF, Hamezah HS, Yanagisawa D, Tsuji M, Kiuchi Y et al. (2021). The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro. Biochemistry and Biophysics Reports. 28: 101131. doi: 10.1016/j.bbrep.2021.101131
- Ibrahim NF, Yanagisawa D, Durani LW, Hamezah HS, Damanhuri HA et al. (2017). Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice. Journal of Alzheimer’s Disease 55 (2): 597- 612. doi: 10.3233/JAD-160685
- Khanna S, Roy S, Parinandi NL (2006). Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. Journal of Neurochemistry 98 (5): 1474-86. doi: 10.1111/j.1471-4159.2006.04000.x
- Lloret A, Esteve D, Monllor P, Cervera-Ferri A, Lloret A (2019). The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease. International Journal of Molecular Sciences 20 (4): 879. doi: 10.3390/ijms20040879
- Mazur-Kolecka B, Golabek A, Nowicki K, Flory M, Frackowiak J (20069. Amyloid-beta impairs development of neuronal progenitor cells by oxidative mechanisms. Neurobiology of Aging 27 (9): 1181-1192. doi: 10.1016/j. neurobiolaging.2005.07.006
- Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S et al. (2004). Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology. 47 (6): 904-915. doi: 10.1016/j. neuropharm.2004.06.029
- Repetto G, del Peso A, Zurita JL (2008). Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nature Protocols 3: 1125-1131. doi: 10.1038/nprot.2008.75
- Rudajev V, Novotny J (2020). The Role of Lipid Environment in GangliosideGM1-InducedAmyloidβAggregation.Membranes (Basel). 10 (9): 226. doi: 0.3390/membranes10090226
- Sciacca MF, Monaco I, La Rosa C, Milardi D (2018). The active role of Ca2+ ions in Aβ-mediated membrane damage. Chemical Communications. 54 (29): 3629-3631. doi: 10.1039/ C8CC01132J
- Sen CK, Khanna S, Roy S (2006). Tocotrienols: Vitamin E beyond tocopherols. Life Sciences 78 (18): 2088-2098. doi: 10.1016/j. lfs.2005.12.001
- Stine WB, Jungbauer L, Yu C, LaDu MJ (2011). Preparing synthetic Aβ in different aggregation states. Alzheimer’s Disease and Frontotemporal Dementia 670: 13-32. doi: 10.1007/978-1- 60761-744-0_2
- Sung S, Yao Y, Uryu K, Yang H, Lee VMY et al (2004). Early vitamin E supplementation in young but not aged mice reduces A-beta levels and amyloid deposition in a transgenic model of Alzheimer’s disease. The FASEB Journal 18 (2): 323-325. doi: 10.1096/fj.03-0961fje
- Then SM, Mazlan M, Top GM, Ngah WZW (2009). Is vitamin E toxic to neuron cells? Cellular and Molecular Neurobiology 29 (4): 485-496. doi: 10.1007/s10571-008-9340-8
- Ulatowski LM, Manor D (2015). Vitamin E and neurodegeneration. Neurobiology of Disease 84: 78-83. doi: 10.1016/j. nbd.2015.04.002
- Ulatowski LM, Parker R, Warrier G (2013). Vitamin E is essential for Purkinje neuron integrity. Neuroscience 260: 120-129. doi: 10.1016/j.neuroscience.2013.12.001
- Yang SG, Wang WY, Ling TJ, Feng Y, Du XT et al (2010). Alpha- tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines. Neurochemistry International 57 (8): 914-922. doi: 10.1016/j.neuint.2010.09.011
- Yatin SM, Varadarajan S, Butterfield DA (2000). Vitamin E Prevents Alzheimer’s Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production. Journal of Alzheimer’s Disease 2 (2): 123-131. doi: 10.3233/ jad-2000-2212
| APA | Özdemir A, AKBAY E, ONUR M (2022). Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. , 388 - 399. 10.55730/1300-0152.2625 |
| Chicago | Özdemir Alp Yiğit,AKBAY ESİN,ONUR MEHMET Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. (2022): 388 - 399. 10.55730/1300-0152.2625 |
| MLA | Özdemir Alp Yiğit,AKBAY ESİN,ONUR MEHMET Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. , 2022, ss.388 - 399. 10.55730/1300-0152.2625 |
| AMA | Özdemir A,AKBAY E,ONUR M Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. . 2022; 388 - 399. 10.55730/1300-0152.2625 |
| Vancouver | Özdemir A,AKBAY E,ONUR M Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. . 2022; 388 - 399. 10.55730/1300-0152.2625 |
| IEEE | Özdemir A,AKBAY E,ONUR M "Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration." , ss.388 - 399, 2022. 10.55730/1300-0152.2625 |
| ISNAD | Özdemir, Alp Yiğit vd. "Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration". (2022), 388-399. https://doi.org/10.55730/1300-0152.2625 |
| APA | Özdemir A, AKBAY E, ONUR M (2022). Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. Turkish Journal of Biology, 46(5), 388 - 399. 10.55730/1300-0152.2625 |
| Chicago | Özdemir Alp Yiğit,AKBAY ESİN,ONUR MEHMET Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. Turkish Journal of Biology 46, no.5 (2022): 388 - 399. 10.55730/1300-0152.2625 |
| MLA | Özdemir Alp Yiğit,AKBAY ESİN,ONUR MEHMET Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. Turkish Journal of Biology, vol.46, no.5, 2022, ss.388 - 399. 10.55730/1300-0152.2625 |
| AMA | Özdemir A,AKBAY E,ONUR M Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. Turkish Journal of Biology. 2022; 46(5): 388 - 399. 10.55730/1300-0152.2625 |
| Vancouver | Özdemir A,AKBAY E,ONUR M Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration. Turkish Journal of Biology. 2022; 46(5): 388 - 399. 10.55730/1300-0152.2625 |
| IEEE | Özdemir A,AKBAY E,ONUR M "Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration." Turkish Journal of Biology, 46, ss.388 - 399, 2022. 10.55730/1300-0152.2625 |
| ISNAD | Özdemir, Alp Yiğit vd. "Comparison of the different isoforms of vitamin e against amyloid beta-induced neurodegeneration". Turkish Journal of Biology 46/5 (2022), 388-399. https://doi.org/10.55730/1300-0152.2625 |
