TY  - JOUR
TI  - Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?
AB  - Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP).  Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxidant, inflammatory and antioxidant parameters were determined in lung and renal tissues.  Results: Oxidant and inflammatory biomarkers increased while antioxidant biomarkers decreased in CLP and DMSO groups compared to sham group. Antioxidant parameters increased while oxidant and inflammatory biomarkers declined in treatment group compared to CLP and DMSO groups.  Conclusion: Present results have demonstrated that URA administration is effective against lung and renal injuries caused by CLP-related polymicrobial sepsis model.
AU  - DOGANAY, Songul
AU  - tanyeli, ayhan
AU  - guler, mustafa can
AU  - Eraslan, Ersen
AU  - Güzel Erdoğan, Derya
DO  - 10.31832/smj.787082
PY  - 2021
JO  - Sakarya Tıp Dergisi
VL  - 11
IS  - 1
SN  - 2146-409X
SP  - 142
EP  - 147
DB  - TRDizin
UR  - http://search/yayin/detay/1141934
ER  -