TY  - JOUR
TI  - Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells
AB  - The 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). The Ru(II)-NHC complexes (4a-h) were synthesized via transmetalation reaction from 3a-e. 4a-h complexes were converted to Ru(II)-NHC.HCl complexes (5a- h) by HCl solution of diethyl ether and characterized by different spectroscopic techniques such as $^1H and ^{13}C$ NMR, LC/MS-Q-TOF, FT-IR, elemental analysis, and melting point detection. We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay. The $IC_{50}$ value of 5b, 5c and 5e complexes exhibited good cytotoxic activity than cisplatin on C6 (14.2 ± 0.5 mM; 16.2 ± 0.4 mM; 24.2 ± 0.7 mM, respectively) and HeLa (11.1 ± 0.5 mM; 13.7 ± 0.3 mM; 22.8 ± 0.8 mM, respectively) cell lines.
AU  - Özdemir, İsmail
AU  - PAŞAHAN, RAMAZAN
AU  - Akkoç, Mitat
AU  - yaşar, sedat
AU  - Kul Köprülü, Tuğba
AU  - YAŞAR, Şeyma
AU  - tekin, saban
DO  - 10.55730/1300-0527.3418
PY  - 2022
JO  - Turkish Journal of Chemistry
VL  - 46
IS  - 4
SN  - 1300-0527
SP  - 1097
EP  - 1109
DB  - TRDizin
UR  - http://search/yayin/detay/1141986
ER  -