TY  - JOUR
TI  - Remdesivir treatment for patients with moderate to severe COVID-19
AB  - Background/aim: Remdesivir, which was first developed for the treatment of Ebola disease but failed to meet expectations, has become hope in the fight against the COVID-19 pandemic. This study aimed to evaluate risk factors for mortality and prognosis of adult moderate/severe COVID-19 patients treated with remdesivir, and safety and tolerability of 5 days of remdesivir treatment. Materials and methods: This multicenter prospective observational study was conducted in 14 centers in Turkey. Pregnancy or breastfeeding, multiorgan failure, or usage of vasopressors for septic shock, ALT > 5 × the upper limit of the normal range, or eGRF <30 mL/min or dialysis and receiving favipiravir were the exclusion criteria of the study. Results: Among 500 patients, 494 patients were included in the study. On admission, 392 (79.3%) patients had moderate and 102 (20.6%) patients had severe COVID-19. The 28-day mortality was 10.1%. The median of the scores of the seven-category ordinal scale assessed on days 0, 3, 5, 7 were 4 and 3 on day 14. When the survival status of the patients was evaluated according to the time between the remdesivir start date and the end date of the symptoms, no statistically significant difference was found between the medians of the groups (p = 0.404). In multivariable analysis, age (OR, 1.05; 95%CI, 1.02–1.08; p = 0.003), $SpO_2$ level on admission (OR, 3.03; 95%CI, 1.35–6.81; p = 0.007), heart rate (OR, 2.48; 95%CI, 1.01–6.07; p = 0.047), follow-up site at the hospital (clinic/ICU) (OR, 26.4; 95%CI, 11.6–60.17; p < 0.001) were independently associated with increased mortality. Grade 3 adverse event (AE) was observed in 4 (0.8%) patients. None of the patients experienced grade 4 or 5 AEs. Conclusion: Remdesivir is a safe and well-tolerated drug and older age, low SpO2 level on admission, tachycardia, and ICU admission are independently associated with increased mortality among patients with moderate/severe COVID-19 receiving remdesivir treatment.
AU  - Unal, Serhat
AU  - Dizman, Gülçin Telli
AU  - Tabak, Fehmi
AU  - ÇAGATAY, ARIF ATAHAN
AU  - Gül, Ahmet
AU  - Şenoğlu, Sevtap
AU  - Kart Yaşar, Kadriye
AU  - Batirel, Ayse
AU  - KANAT, FIKRET
AU  - Kazak, Esra
AU  - Hasanoglu, Imran
AU  - GÜNER, RAHMET
AU  - Yildiz Sevgi, Dilek
AU  - KARAALİ, Rıdvan
AU  - bozkurt, ilkay
AU  - kocagül çelikbaş, aysel
AU  - Pullukçu, Hüsnü
AU  - Eryilmaz-Eren, Esma
AU  - Çelik, İlhami
AU  - Alp, Emine
AU  - ERDINC, Fatma Sebnem
DO  - 10.55730/1300-0144.5387
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 4
SN  - 1300-0144
SP  - 880
EP  - 887
DB  - TRDizin
UR  - http://search/yayin/detay/1143211
ER  -