Yıl: 2022 Cilt: 52 Sayı: 4 Sayfa Aralığı: 1041 - 1049 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5406 İndeks Tarihi: 14-12-2022

Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder

Öz:
Background/aim: Neurofilaments are intermediary filaments associated with neurodegenerative processes. Thrombospondin-1 (TSP- 1) is a biological marker playing a role in synaptogenesis. This study aimed to investigate serum neurofilament light chain (NFL), and TSP1 levels of patients with autism spectrum disorder (ASD) compared to typically developing (TD) children. Materials and methods: Forty-three patients with ASD and forty-five TD children were included. Serum biomarker levels were measured using the sandwich ELISA technique. The Childhood Autism Rating Scale (CARS) was implemented to measure the severity of ASD. Results: NFL and TSP1 levels did not differ between study groups (For NFL, ASD = 47.8 ± 11.4 vs. TD = 48.2 ± 15.3 pg/mL, p = 0.785; for TSP1, ASD = 224.4 ± 53.7 vs. TD = 224.7 ± 69.0 ng/mL, p = 0.828). Stereotyped behavior and sensory sensitivity domain of the CARS scale was negatively correlated with serum TSP-1 (r = –0.390, p = 0.010) and NFL (r = –0.377, p = 0.013) levels. Age was also positively correlated with NFL levels (r = 0.332, p = 0.030) in the ASD groups but not in the TD group. Conclusion: Our results did not support the neurodegenerative process of ASD. Future studies are needed to investigate neuroprogression in a longitudinal follow-up.
Anahtar Kelime: Neurofilament light chain thrombospondin autism neurodegeneration

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA PAKETÇI C, Ermiş Ç, Şişman A, Hız A, Baykara H, yiş u (2022). Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. , 1041 - 1049. 10.55730/1300-0144.5406
Chicago PAKETÇI CEM,Ermiş Çağatay,Şişman Ali Rıza,Hız Ayşe Semra,Baykara Huseyin Burak,yiş uluç Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. (2022): 1041 - 1049. 10.55730/1300-0144.5406
MLA PAKETÇI CEM,Ermiş Çağatay,Şişman Ali Rıza,Hız Ayşe Semra,Baykara Huseyin Burak,yiş uluç Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. , 2022, ss.1041 - 1049. 10.55730/1300-0144.5406
AMA PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. . 2022; 1041 - 1049. 10.55730/1300-0144.5406
Vancouver PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. . 2022; 1041 - 1049. 10.55730/1300-0144.5406
IEEE PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u "Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder." , ss.1041 - 1049, 2022. 10.55730/1300-0144.5406
ISNAD PAKETÇI, CEM vd. "Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder". (2022), 1041-1049. https://doi.org/10.55730/1300-0144.5406
APA PAKETÇI C, Ermiş Ç, Şişman A, Hız A, Baykara H, yiş u (2022). Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. Turkish Journal of Medical Sciences, 52(4), 1041 - 1049. 10.55730/1300-0144.5406
Chicago PAKETÇI CEM,Ermiş Çağatay,Şişman Ali Rıza,Hız Ayşe Semra,Baykara Huseyin Burak,yiş uluç Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. Turkish Journal of Medical Sciences 52, no.4 (2022): 1041 - 1049. 10.55730/1300-0144.5406
MLA PAKETÇI CEM,Ermiş Çağatay,Şişman Ali Rıza,Hız Ayşe Semra,Baykara Huseyin Burak,yiş uluç Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. Turkish Journal of Medical Sciences, vol.52, no.4, 2022, ss.1041 - 1049. 10.55730/1300-0144.5406
AMA PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. Turkish Journal of Medical Sciences. 2022; 52(4): 1041 - 1049. 10.55730/1300-0144.5406
Vancouver PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder. Turkish Journal of Medical Sciences. 2022; 52(4): 1041 - 1049. 10.55730/1300-0144.5406
IEEE PAKETÇI C,Ermiş Ç,Şişman A,Hız A,Baykara H,yiş u "Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder." Turkish Journal of Medical Sciences, 52, ss.1041 - 1049, 2022. 10.55730/1300-0144.5406
ISNAD PAKETÇI, CEM vd. "Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder". Turkish Journal of Medical Sciences 52/4 (2022), 1041-1049. https://doi.org/10.55730/1300-0144.5406