Yıl: 2020 Cilt: 10 Sayı: 3 Sayfa Aralığı: 1848 - 1856 Metin Dili: İngilizce DOI: 10.21597/jist.702359 İndeks Tarihi: 15-12-2022

The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme

Öz:
Angiotensin converting enzyme (ACE, peptidyldipeptidase A, EC 3.4.15.1) has got a significant role in the arrangement of blood pressure. ACE inhibitors usually play a part in the therapies of hypertension. Hypertension is an significant cardiovascular risk factor. The main purpose of the treatment is to reduce the incidence of hypertension. In this study, the inhibition effect of butanol and water extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on angiotensin converting enzyme (ACE) activity in human plasma was investigated. ACE activity was calculated at 345 nm spectrophotometrically. Extracts of Thymbra sintenisii Bornm. et Aznav. subsp plant with water and butanol were made. The effectiveness of these extracts on ACE activity was researched. Water and butanol extracts of Thymbra sintenisii indicated inhibition impact on ACE. IC50 values for water and butanol extracts of Thymbra sintenisii was measured to be 1.696 mg mL-1 and 0.395 mg mL-1 respectively. Inhibition type for water and butanol extracts of Thymbra sintenisii from Lineweaver-Burk chart was defined to be non-competitive inhibition. Synthetic ACE inhibitors are utilized in the therapy of hypertension. On the other hand, synthetic ACE inhibitors exhibit a large number of adverse effects. Therefore, ACE inhibitors have been newly researched from native herbs. These conclusions demonstrate that water and butanol extracts of Thymbra sintenisii plant may have an ACE inhibition capacity.
Anahtar Kelime: Angiotensin converting enzyme Inhibition Thymbra sintenisii Hypertension

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Gür T, Karahan F, TÜRKOĞLU V, BAŞ Z (2020). The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. , 1848 - 1856. 10.21597/jist.702359
Chicago Gür Tuğba,Karahan Fatih,TÜRKOĞLU Vedat,BAŞ Zehra The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. (2020): 1848 - 1856. 10.21597/jist.702359
MLA Gür Tuğba,Karahan Fatih,TÜRKOĞLU Vedat,BAŞ Zehra The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. , 2020, ss.1848 - 1856. 10.21597/jist.702359
AMA Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. . 2020; 1848 - 1856. 10.21597/jist.702359
Vancouver Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. . 2020; 1848 - 1856. 10.21597/jist.702359
IEEE Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z "The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme." , ss.1848 - 1856, 2020. 10.21597/jist.702359
ISNAD Gür, Tuğba vd. "The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme". (2020), 1848-1856. https://doi.org/10.21597/jist.702359
APA Gür T, Karahan F, TÜRKOĞLU V, BAŞ Z (2020). The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 10(3), 1848 - 1856. 10.21597/jist.702359
Chicago Gür Tuğba,Karahan Fatih,TÜRKOĞLU Vedat,BAŞ Zehra The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10, no.3 (2020): 1848 - 1856. 10.21597/jist.702359
MLA Gür Tuğba,Karahan Fatih,TÜRKOĞLU Vedat,BAŞ Zehra The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol.10, no.3, 2020, ss.1848 - 1856. 10.21597/jist.702359
AMA Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 10(3): 1848 - 1856. 10.21597/jist.702359
Vancouver Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 10(3): 1848 - 1856. 10.21597/jist.702359
IEEE Gür T,Karahan F,TÜRKOĞLU V,BAŞ Z "The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme." Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 10, ss.1848 - 1856, 2020. 10.21597/jist.702359
ISNAD Gür, Tuğba vd. "The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme". Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10/3 (2020), 1848-1856. https://doi.org/10.21597/jist.702359