TY  - JOUR
TI  - Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Behçet’s disease
AB  - Background/aim: Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet’s disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Behçet’s disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods: Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for an average follow-up period of 3.9 ± 1.3 years. Results: Parenchymal NBD patients showed elevated CSF levels of NFL, HoxB3, and YKL-40 as compared to nonparenchymal patients. NBD patients showing an increase in modified Rankin score (mRS) values during follow-up had significantly higher CSF NFL levels. Patients with relatively lower CSF NFL levels (<1000 ng/L) did not develop attacks or cognitive impairment interfering with daily life activities during follow-up. NFL levels correlated with disease duration and mRS at the last follow-up visit, while HoxB3 levels correlated with a number of attacks during follow-up. Conclusion: CSF level of NFL appears to predict the prospective somatic and cognitive disability in NBD patients and may thus be potentially used as a biomarker of clinical outcome in this disease.
AU  - Kucukali, Cem Ismail
AU  - Şanlı, Elif
AU  - Akbayır, Ece
AU  - Koral, Gizem
AU  - içöz, sema
AU  - GÜNDÜZ, TUNCAY
AU  - Timirci-Kahraman, Ozlem
AU  - Karaaslan, Zerrin
AU  - Tuzun, Erdem
AU  - Kürtüncü, Murat
AU  - YILMAZ, VUSLAT
DO  - 10.55730/1300-0144.5432
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 4
SN  - 1300-0144
SP  - 1266
EP  - 1273
DB  - TRDizin
UR  - http://search/yayin/detay/1144848
ER  -