Microglial iron trafficking: new player in brain injury

KELES GULNERMAN, Elif; Aral, Arzu L.; Bolay, Hayrunnisa; Kazan, Hasan

doi:10.55730/1300-0144.5481

Microglial iron trafficking: new player in brain injury

Elif KELEŞ GÜLNERMAN, (Gazi Üniversitesi, Tıp Fakültesi, Nöropsikiyatri Eğitim, Araştırma ve Uygulama Merkezi, Ankara, Türkiye)

Hasan Hüseyin KAZAN, (Gazi Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Ankara, Türkiye)

LATİFE ARZU ARAL, (Nörobilim ve Nöroteknoloji Mükemmeliyet Merkezi (NÖROM), Ankara, Türkiye)

Hayrunnisa BOLAY (Gazi Üniversitesi, Tıp Fakültesi, Nöropsikiyatri Eğitim, Araştırma ve Uygulama Merkezi, Ankara, Türkiye)

Turkish Journal of Medical Sciences

4 0

Yıl: 2022 Cilt: 52 Sayı: 5 Sayfa Aralığı: 1415 - 1424 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5481 İndeks Tarihi: 27-12-2022

Microglial iron trafficking: new player in brain injury

Öz:

Abstract: Neonatal brain injury is a significant reason of neurodevelopmental abnormalities and long-term neurological impairments. Hypoxic-ischemic encephalopathy and preterm brain injury, including intraventricular hemorrhage are the most common grounds of brain injury for full-term and preterm neonates. The prevalence of hypoxic ischemic encephalopathy varies globally, ranging from 1 to 3.5/1000 live births in high-resource countries and 26/1000 in low-resource countries. Preterm birth’s global incidence is 15 million, a significant reason for infant mortality and morbidity, permanent neurologic problems, and the associated social and economic burden. The widespread neurodevelopmental effects of neonatal brain injury could have an unfavorable impact on a variety of aspects of cognitive, linguistic, behavioral, sensory, and motor functions. Brain injury occurs via various mechanisms, including energy deprivation, excitatory amino acids, mitochondrial dysfunction, reactive oxygen species, and inflammation giving rise to different forms of cell death. The contribution of microglial activity in neonatal brain injury has widely been underlined by focusing on cell death mechanisms since the neuronal death pathways during their development are distinct from those in the adult brain. Iron accumulation and lipid peroxidation cause a relatively novel type of regulated cell death called ferroptosis. Neonates generally have biochemical iron inequalities, and their antioxidant potential is highly restricted, implying that ferroptosis may be significant in pathologic conditions. Moreover, inhaled nitric oxide therapy in infants may lead to microglial inflammation via ferroptosis and neuronal injury in the developing brain. This review article aims to summarize the studies that investigated the association between neonatal brain injury and iron metabolism, with a particular emphasis on the microglial activity and its application to the inhibition of neonatal brain injury.

Anahtar Kelime: Neonatal brain development brain injury in neonates microglia iron metabolism lipid peroxidation ferroptosis

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	KELES GULNERMAN E, Kazan H, Aral A, Bolay H (2022). Microglial iron trafficking: new player in brain injury. , 1415 - 1424. 10.55730/1300-0144.5481
Chicago	KELES GULNERMAN Elif,Kazan Hasan,Aral Arzu L.,Bolay Hayrunnisa Microglial iron trafficking: new player in brain injury. (2022): 1415 - 1424. 10.55730/1300-0144.5481
MLA	KELES GULNERMAN Elif,Kazan Hasan,Aral Arzu L.,Bolay Hayrunnisa Microglial iron trafficking: new player in brain injury. , 2022, ss.1415 - 1424. 10.55730/1300-0144.5481
AMA	KELES GULNERMAN E,Kazan H,Aral A,Bolay H Microglial iron trafficking: new player in brain injury. . 2022; 1415 - 1424. 10.55730/1300-0144.5481
Vancouver	KELES GULNERMAN E,Kazan H,Aral A,Bolay H Microglial iron trafficking: new player in brain injury. . 2022; 1415 - 1424. 10.55730/1300-0144.5481
IEEE	KELES GULNERMAN E,Kazan H,Aral A,Bolay H "Microglial iron trafficking: new player in brain injury." , ss.1415 - 1424, 2022. 10.55730/1300-0144.5481
ISNAD	KELES GULNERMAN, Elif vd. "Microglial iron trafficking: new player in brain injury". (2022), 1415-1424. https://doi.org/10.55730/1300-0144.5481

APA	KELES GULNERMAN E, Kazan H, Aral A, Bolay H (2022). Microglial iron trafficking: new player in brain injury. Turkish Journal of Medical Sciences, 52(5), 1415 - 1424. 10.55730/1300-0144.5481
Chicago	KELES GULNERMAN Elif,Kazan Hasan,Aral Arzu L.,Bolay Hayrunnisa Microglial iron trafficking: new player in brain injury. Turkish Journal of Medical Sciences 52, no.5 (2022): 1415 - 1424. 10.55730/1300-0144.5481
MLA	KELES GULNERMAN Elif,Kazan Hasan,Aral Arzu L.,Bolay Hayrunnisa Microglial iron trafficking: new player in brain injury. Turkish Journal of Medical Sciences, vol.52, no.5, 2022, ss.1415 - 1424. 10.55730/1300-0144.5481
AMA	KELES GULNERMAN E,Kazan H,Aral A,Bolay H Microglial iron trafficking: new player in brain injury. Turkish Journal of Medical Sciences. 2022; 52(5): 1415 - 1424. 10.55730/1300-0144.5481
Vancouver	KELES GULNERMAN E,Kazan H,Aral A,Bolay H Microglial iron trafficking: new player in brain injury. Turkish Journal of Medical Sciences. 2022; 52(5): 1415 - 1424. 10.55730/1300-0144.5481
IEEE	KELES GULNERMAN E,Kazan H,Aral A,Bolay H "Microglial iron trafficking: new player in brain injury." Turkish Journal of Medical Sciences, 52, ss.1415 - 1424, 2022. 10.55730/1300-0144.5481
ISNAD	KELES GULNERMAN, Elif vd. "Microglial iron trafficking: new player in brain injury". Turkish Journal of Medical Sciences 52/5 (2022), 1415-1424. https://doi.org/10.55730/1300-0144.5481