Yıl: 2022 Cilt: 52 Sayı: 5 Sayfa Aralığı: 1495 - 1503 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5488 İndeks Tarihi: 27-12-2022

The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19

Öz:
Background/aim: Acute kidney injury is strongly associated with mortality in critically ill patients with coronavirus disease 2019 (COVID-19); however, age-related risk factors for acute kidney injury are not clear yet. In this study, it was aimed to evaluate the effects of clinical factors on acute kidney injury development in an elderly COVID-19 patients. Materials and methods: Critically ill patients (≥65years) with COVID-19 admitted to the intensive care unit were included in the study. Primary outcome of the study was the rate of acute kidney injury, and secondary outcome was to define the effect of frailty and other risk factors on acute kidney injury development and mortality. Results: A total of 132 patients (median age 76 years, 68.2% male) were assessed. Patients were divided into two groups as follows: acute kidney injury (n = 84) and nonacute kidney injury (n = 48). Frailty incidence (48.8% vs. 8.3%, p < 0.01) was higher in the acute kidney injury group. In multivariate analysis, frailty (OR, 3.32, 95% CI, 1.67–6.56), the use of vasopressors (OR, 3.06 95% CI, 1.16–8.08), and the increase in respiratory support therapy (OR, 2.60, 95% CI, 1.01–6.6) were determined to be independent risk factors for acute kidney injury development. The mortality rate was found to be 97.6% in patients with acute kidney injury. Conclusion: Frailty is a risk factor for acute kidney injury in geriatric patients with severe COVID-19. The evaluation of geriatric patients based on a frailty scale before intensive care unit admission may improve outcomes.
Anahtar Kelime: Frailty COVID-19 acute kidney injury intensive care

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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  • 1. Cevik M, Bamford CGG, Ho A. COVID-19 pandemic-a focused review for clinicians. Clinical Microbiology and Infection 2020; 26(7): 842-847. https://doi.org/10.1016/j. cmi.2020.04.023
  • 2. Mueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging (Albany NY) 2020; 12(10): 9959-9981. https://doi.org/10.18632/aging.103344
  • 3. Guan W-J, Liang W-H, Zhao Y, Liang HR, Chen ZS et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal 2020; 55(5): 2000547. https://doi.org/10.1183/13993003.00547- 2020
  • 4. Zhou F, Yu T, Du R, Fan G, Liu Y et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054-1062. https://doi.org/10.1016/S0140- 6736(20)30566-3
  • 5. Chronopoulos A, Cruz DN, Ronco C. Hospital-acquired acute kidney injury in the elderly. Nature Reviews Nephrology 2010; 6(3): 141-149. https://doi.org/10.1038/nrneph.2009.234
  • 6. Anderson S, Eldadah B, Halter JB, Himmelfarb J, Horne FM et al. Acute kidney injury in older adults. Journal of American Society of Nephrology 2011; 22(1): 28-38. https://doi. org/10.1681/ASN.2008080860
  • 7. Cheng Y, Luo R, Wang K, Zhang M, Wang Z et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International 2020; 97(5): 829-838. https:// doi.org/10.1016/j.kint.2020.03.005.
  • 8. Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, Kathleen DL et al. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol 2020; 16(12): 747-764. https:// doi.org/10.1038/s41581-020-00356-5
  • 9. Diao B, Wang C, Wang R, Feng Z, Zhang J et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nature Communications 2021; 12(1): 2506. https://doi.org/10.1038/s41467-021-22781-1.
  • 10. Werion A, Belkhir L, Perrot M, Schmit G, Aydin S et al. SARS- CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney International 2020; 98(5): 1296-1307. https:// doi.org/10.1016/j.kint.2020.07.019.
  • 11. Su H, Yang M, Wan C, Yi LX, Tang F et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney International 2020; 98(1): 219-227. https:// doi.org/10.1016/j.kint.2020.04.003.
  • 12. Moledina DG, Simonov M, Yamamoto M, Alausa J, Arora T et al. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. Am J Kidney Dis 2021; 77(4): 490-499. https://doi. org/10.1053/j.ajkd.2020.12.007
  • 13. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C et al. Frailty in older adults: evidence for a phenotype. The Journals of Gerontology: Series A 2001; 56(3): M146-56. https://doi. org/10.1093/gerona/56.3.m146
  • 14. Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med 2011; 27(1): 1-15. https://doi. org/10.1016/j.cger.2010.08.009
  • 15. McIsaac DI, MacDonald DB, Aucoin SD. Frailty for Perioperative Clinicians: A Narrative Review. Anesth Analg 2020; 130(6): 1450-1460. https://doi.org/10.1213/ANE.0000000000004602
  • 16. Bagshaw SM, Stelfox HT, McDermid RC, Rolfson DB, Tsuyuki RT et al. Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study. Canadian Medical Association Journal 2014; 186(2): E95-102. https://doi.org/10.1503/cmaj.130639.
  • 17. Kizilarslanoglu MC, Civelek R, Kilic MK, Sumer F, Varan HD et al. Is frailty a prognostic factor for critically ill elderly patients? Aging Clinical and Experimental Research 2017; 29(2): 247- 255. https://doi.org/10.1007/s40520-016-0557-y
  • 18. Abdel-Kader K, Girard TD, Brummel NE, Saunders CT, Blume JD et al. Acute Kidney Injury and Subsequent Frailty Status in Survivors of Critical Illness: A Secondary Analysis. Critical Care Medicine 2018; 46(5): e380-e388. https://doi.org/10.1097/ CCM.0000000000003003.
  • 19. Kellum JA, Lameire N, KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Critical Care. 2013; 17(1): 204. https://doi.org/10.1186/cc11454.
  • 20. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315(8): 801-10. https://doi.org/10.1001/jama.2016.0287.
  • 21. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clinical Infectious Diseases 2016; 63(5): e61-e111. https://doi.org/10.1093/cid/ciw353.
  • 22. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ et al. Fourth Universal Definition of Myocardial Infarction (2018). Journal of the American College of Cardiology. 2018; 72(18): 2231-2264. https://doi.org/10.1016/j.jacc.2018.08.1038.
  • 23. Dechert RE, Park PK, Bartlett RH. Evaluation of the oxygenation index in adult respiratory failure. J Trauma Acute Care Surg 2014; 76(2): 469-73. https://doi.org/10.1097/ TA.0b013e3182ab0d27
  • 24. Aprahamian I, Cezar NO de C, Izbicki R, Lin SM, Paulo DLV et al. Screening for Frailty With the FRAIL Scale: A Comparison With the Phenotype Criteria. Journal of American Medical Directors Association 2017; 18(7): 592-596. https://doi. org/10.1016/j.jamda.2017.01.009.
  • 25. Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney International 2020; 98(1): 209-218. https://doi.org/10.1016/j. kint.2020.05.006.
  • 26. Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A et al. Acute Kidney Injury in Hospitalized Patients with COVID-19. Journal of the American Society of Nephrology 2021; 32(1): 151-160. https://doi.org/10.1681/ASN.2020050615.
  • 27. Gündoğan K, Temel Ş, Ketencioğlu BB, Rabah B, Tutar N et al. Acute Kidney Injury in SARS-CoV-2 Infected Critically Ill Patients. Turk J Nephrol 2020; 29(3): 185-189. https://doi.org/ 10.5152/turkjnephrol.2020.4448
  • 28. Alessandri F, Pistolesi V, Manganelli C, Ruberto F, Ceccarelli G et al. Acute Kidney Injury and COVID-19: A Picture from an Intensive Care Unit. Blood Purification. 2021; (7): 1-5. https:// doi.org/10.1159/000513153.
  • 29. Piñeiro GJ, Molina-Andújar A, Hermida E, Blasco M, Quintana LF et al. Severe acute kidney injury in critically ill COVID-19 patients. Journal of Nephrology; 34(2): 285-293. https://doi. org/10.1007/s40620-020-00918-7.
  • 30. Basile-Filho A, Lago AF, Menegueti MG, Nicolini EA, Rodrigues LAB et al. The use of APACHE II, SOFA, SAPS 3, C-reactive protein/albumin ratio, and lactate to predict mortality of surgical critically ill patients: A retrospective cohort study. Medicine (Baltimore). 2019; 98(26): e16204. https://doi.org/10.1097/MD.0000000000016204
  • 31. Thompson MQ, Theou O, Tucker GR, Adams RJ, Visvanathan R. FRAIL scale: Predictive validity and diagnostic test accuracy. Australas J Ageing 2020; 39(4): e529-e536. https://doi.org/ 10.1111/ajag.12829
  • 32. Li Q, Zhang T, Li F, Mao Z, Kang H et al. Acute Kidney Injury Can Predict In-Hospital Mortality in Elderly Patients with COVID-19 in the ICU: A Single-Center Study. Clin Interventinals in Aging 2020; (15): 2095-2107. https://doi. org/10.2147/CIA.S273720
APA Küçük M, ERGÜN B, Yakar M, Çakıcı Ö, Yaka E, COMERT B, Gökmen N, ergan b (2022). The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. , 1495 - 1503. 10.55730/1300-0144.5488
Chicago Küçük Murat,ERGÜN BİŞAR,Yakar Mehmet Nuri,Çakıcı Özer Ural,Yaka Erdem,COMERT BILGIN,Gökmen Necati,ergan begum The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. (2022): 1495 - 1503. 10.55730/1300-0144.5488
MLA Küçük Murat,ERGÜN BİŞAR,Yakar Mehmet Nuri,Çakıcı Özer Ural,Yaka Erdem,COMERT BILGIN,Gökmen Necati,ergan begum The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. , 2022, ss.1495 - 1503. 10.55730/1300-0144.5488
AMA Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. . 2022; 1495 - 1503. 10.55730/1300-0144.5488
Vancouver Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. . 2022; 1495 - 1503. 10.55730/1300-0144.5488
IEEE Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b "The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19." , ss.1495 - 1503, 2022. 10.55730/1300-0144.5488
ISNAD Küçük, Murat vd. "The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19". (2022), 1495-1503. https://doi.org/10.55730/1300-0144.5488
APA Küçük M, ERGÜN B, Yakar M, Çakıcı Ö, Yaka E, COMERT B, Gökmen N, ergan b (2022). The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. Turkish Journal of Medical Sciences, 52(5), 1495 - 1503. 10.55730/1300-0144.5488
Chicago Küçük Murat,ERGÜN BİŞAR,Yakar Mehmet Nuri,Çakıcı Özer Ural,Yaka Erdem,COMERT BILGIN,Gökmen Necati,ergan begum The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. Turkish Journal of Medical Sciences 52, no.5 (2022): 1495 - 1503. 10.55730/1300-0144.5488
MLA Küçük Murat,ERGÜN BİŞAR,Yakar Mehmet Nuri,Çakıcı Özer Ural,Yaka Erdem,COMERT BILGIN,Gökmen Necati,ergan begum The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. Turkish Journal of Medical Sciences, vol.52, no.5, 2022, ss.1495 - 1503. 10.55730/1300-0144.5488
AMA Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. Turkish Journal of Medical Sciences. 2022; 52(5): 1495 - 1503. 10.55730/1300-0144.5488
Vancouver Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19. Turkish Journal of Medical Sciences. 2022; 52(5): 1495 - 1503. 10.55730/1300-0144.5488
IEEE Küçük M,ERGÜN B,Yakar M,Çakıcı Ö,Yaka E,COMERT B,Gökmen N,ergan b "The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19." Turkish Journal of Medical Sciences, 52, ss.1495 - 1503, 2022. 10.55730/1300-0144.5488
ISNAD Küçük, Murat vd. "The effect of frailty on the development of acute kidney injury in critically-ill geriatric patients with COVID-19". Turkish Journal of Medical Sciences 52/5 (2022), 1495-1503. https://doi.org/10.55730/1300-0144.5488