TY  - JOUR
TI  - Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma
AB  - Background/aim: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. Materials and methods: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. Results: The median PFS (mPFS) was 10.1 months (95% CI, 6.8–13.4) in the FLOT arm (n = 33) and 7.4 months (95% CI, 9.1–21.6) in the mDCF arm (n = 39) (p = 0.041). The median OS (mOS) was 12.9 months (95% CI, 9.7–16.1) in the FLOT arm and 15.4 months (95% CI, 9.1–21.6) in the mDCF arm (p = 0.622). It was found that all grade neutropenia was 51.3% vs. 72.7% (p = 0.063), febrile neutropenia was 8.3% vs. 6.3% (p = 0.743), and thrombocytopenia was 48.7% vs. 51.5% (p = 0.813) in the FLOT and mDCF arms, respectively. Anemia was 59% in the FLOT arm and 100% in the mDCF arm (p < 0.001). Grade 3-4 anemia was 7.7% in the FLOT arm and 24.2% in the mDCF arm (p = 0.052). Conclusion: It was shown that the mPFS was significantly increased in the FLOT arm compared to the mDCF arm as the first-line treatment in patients with metastatic GC and GEJC. Hematological adverse events were more favorable in the FLOT arm than in themmDCF arm.
AU  - Ozdemir, Nuriye
AU  - Yazıcı, Ozan
AU  - arık, zafer
AU  - yalcin, suayib
AU  - AYDEMİR, Ergin
AU  - sutcuoglu, osman
AU  - Ozet, Ahmet
AU  - Guven, Deniz Can
AU  - kurt inci, bediz
AU  - Gürler, Fatih
DO  - 10.55730/1300-0144.5496
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 5
SN  - 1300-0144
SP  - 1559
EP  - 1568
DB  - TRDizin
UR  - http://search/yayin/detay/1145126
ER  -