Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients

KARAKAŞ, NAZMİ MUTLU; Kaya, Zuhre; Kirkiz, Serap

doi:10.55730/1300-0144.5509

Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients

Nazmi Mutlu KARAKAŞ, (Gazi Üniversitesi, Tıp Fakültesi, Genel Pediatri Anabilim Dalı, Ankara, Türkiye)

Serap KİRKİZ, (Gazi Üniversitesi, Tıp Fakültesi, Pediatrik Hematoloji Anabilim Dalı, Ankara, Türkiye)

Zühre KAYA (Gazi Üniversitesi, Tıp Fakültesi, Pediatrik Hematoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

4 0

Yıl: 2022 Cilt: 52 Sayı: 5 Sayfa Aralığı: 1674 - 1681 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5509 İndeks Tarihi: 27-12-2022

Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients

Öz:

Background/aim: This study aims to investigate the diagnostic utility of new erythrocytes, leukocytes, and reticulocytes parameters for the identification of subclinical iron deficiency (ID) in children under 6 years with nonsevere acute infection in pediatric outpatients. Materials and methods: The study included 102 children with acute infections and 31 true ID. Traditional and new hematology parameters were measured in a Sysmex-XN®, along with C-reactive protein level, and iron parameters. Participants’ ID were categorized as: the ferritin < 100 ng/mL, transferrin saturation < 20% was defined as “subclinical or functional ID (FID) in Group 1”; ferritin < 30 ng/mL, transferrin saturation < 20%, as “absolute-ID (AID)” in Group 2; ferritin < 12 ng/mL without anemia and infection, as “true ID” in Group 3. Results: The frequencies of FID and AID among the 102 children with acute infection were 24% and 76%, respectively. Compared with the Group 2 patients, Group 1 had a significantly higher mean percentage of hypochromic erythrocytes (Hypo-He), and significantly lower levels of hemoglobin (Hb) and Hb content of reticulocytes (RET-He) (p < 0.05 for all). Compared with Group 2 and Group 3 patients, Group 1 had a significantly higher mean percentage of immature reticulocyte fraction (IRF) and immature granulocyte (IG) values (p < 0.05 for all). The RET-He, IRF%, Hypo-He%, and IG% cut-off values for predicting FID during infection were 27.0 pg, 10.6%, 2.5%, and 0.35% respectively. Conclusion: The RET-He, Hypo-He, IRF, and IG may be useful parameters for identifying subclinical ID in small children with nonsevere acute infection in pediatric outpatients.

Anahtar Kelime: Iron deficiency child infection

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARAKAŞ N, Kirkiz S, Kaya Z (2022). Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. , 1674 - 1681. 10.55730/1300-0144.5509
Chicago	KARAKAŞ NAZMİ MUTLU,Kirkiz Serap,Kaya Zuhre Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. (2022): 1674 - 1681. 10.55730/1300-0144.5509
MLA	KARAKAŞ NAZMİ MUTLU,Kirkiz Serap,Kaya Zuhre Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. , 2022, ss.1674 - 1681. 10.55730/1300-0144.5509
AMA	KARAKAŞ N,Kirkiz S,Kaya Z Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. . 2022; 1674 - 1681. 10.55730/1300-0144.5509
Vancouver	KARAKAŞ N,Kirkiz S,Kaya Z Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. . 2022; 1674 - 1681. 10.55730/1300-0144.5509
IEEE	KARAKAŞ N,Kirkiz S,Kaya Z "Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients." , ss.1674 - 1681, 2022. 10.55730/1300-0144.5509
ISNAD	KARAKAŞ, NAZMİ MUTLU vd. "Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients". (2022), 1674-1681. https://doi.org/10.55730/1300-0144.5509

APA	KARAKAŞ N, Kirkiz S, Kaya Z (2022). Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. Turkish Journal of Medical Sciences, 52(5), 1674 - 1681. 10.55730/1300-0144.5509
Chicago	KARAKAŞ NAZMİ MUTLU,Kirkiz Serap,Kaya Zuhre Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. Turkish Journal of Medical Sciences 52, no.5 (2022): 1674 - 1681. 10.55730/1300-0144.5509
MLA	KARAKAŞ NAZMİ MUTLU,Kirkiz Serap,Kaya Zuhre Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. Turkish Journal of Medical Sciences, vol.52, no.5, 2022, ss.1674 - 1681. 10.55730/1300-0144.5509
AMA	KARAKAŞ N,Kirkiz S,Kaya Z Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. Turkish Journal of Medical Sciences. 2022; 52(5): 1674 - 1681. 10.55730/1300-0144.5509
Vancouver	KARAKAŞ N,Kirkiz S,Kaya Z Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients. Turkish Journal of Medical Sciences. 2022; 52(5): 1674 - 1681. 10.55730/1300-0144.5509
IEEE	KARAKAŞ N,Kirkiz S,Kaya Z "Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients." Turkish Journal of Medical Sciences, 52, ss.1674 - 1681, 2022. 10.55730/1300-0144.5509
ISNAD	KARAKAŞ, NAZMİ MUTLU vd. "Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients". Turkish Journal of Medical Sciences 52/5 (2022), 1674-1681. https://doi.org/10.55730/1300-0144.5509