Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination

ISGOREN, SERKAN; Köroğlu, Gizem; daglioz gorur, gozde; Demir, Hakan

doi:10.55730/1300-0144.5519

Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination

SERKAN ISGOREN, (Kocaeli Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı Kocaeli, Türkiye)

Gizem KÖROĞLU, (Kocaeli Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı Kocaeli, Türkiye)

Gözde DAĞLIÖZ GÖRÜR, (Kocaeli Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı Kocaeli, Türkiye)

Hakan DEMİR (Kocaeli Üniversitesi, Tıp Fakültesi, Nükleer Tıp Anabilim Dalı Kocaeli, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2022 Cilt: 52 Sayı: 6 Sayfa Aralığı: 1745 - 1753 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5519 İndeks Tarihi: 28-12-2022

Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination

Öz:

Background/aim: It is important to evaluate the vaccine-related metabolic changes on FDG PET/CT to avoid confusing results. We here aimed to assess the frequency and intensity of regional and systemic metabolic PET/CT changes of patients who received the mRNA- based COVID-19 vaccine (BNT162b2-Pfizer/BioNTech) and to analyze possible factors affecting these changes. Materials and methods: Among the patients who underwent FDG PET/CT for any indication in our department between July 2021 and December 2021, 129 volunteer patients with a history of COVID-19 vaccination were included in this prospective observational study. Bilateral axillary lymph nodes, ipsilateral deltoid muscle, bone marrow, spleen, thyroid, and liver FDG uptakes were evaluated visually and semiquantitatively for each examination. Results: The frequencies of positive axillary lymph nodes after vaccination were 40%, 44.4%, 32.6%, and 44.7% in all, 1st dose, 2nd dose, and heterologous vaccination regimens groups, respectively. Maximum standardized uptake values of spleen, liver, and bone marrow were statistically high in patients with positive axillary lymph nodes than with negative ones (p < 0.05). Positive deltoid muscle uptake and diffusely increased thyroid uptake findings were observed in 10 and 8 patients, respectively. The median time interval between vaccination and imaging was 9.5 days for patients with positive axillary lymph nodes and 17 days for patients with negative nodes. In our study group, only 8 patients had a positive documented history of COVID-19 infection. Conclusion: Regional and systemic metabolic changes were occasionally found on FDG PET/CT imaging in patients who received the mRNA-based COVID-19 vaccine. To avoid these timely decreasing changes, we recommend managing the ideal timing of imaging or vaccination and taking a careful history.

Anahtar Kelime: COVID-19 vaccines positron emission tomography messenger RNA

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ISGOREN S, Köroğlu G, daglioz gorur g, Demir H (2022). Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. , 1745 - 1753. 10.55730/1300-0144.5519
Chicago	ISGOREN SERKAN,Köroğlu Gizem,daglioz gorur gozde,Demir Hakan Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. (2022): 1745 - 1753. 10.55730/1300-0144.5519
MLA	ISGOREN SERKAN,Köroğlu Gizem,daglioz gorur gozde,Demir Hakan Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. , 2022, ss.1745 - 1753. 10.55730/1300-0144.5519
AMA	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. . 2022; 1745 - 1753. 10.55730/1300-0144.5519
Vancouver	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. . 2022; 1745 - 1753. 10.55730/1300-0144.5519
IEEE	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H "Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination." , ss.1745 - 1753, 2022. 10.55730/1300-0144.5519
ISNAD	ISGOREN, SERKAN vd. "Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination". (2022), 1745-1753. https://doi.org/10.55730/1300-0144.5519

APA	ISGOREN S, Köroğlu G, daglioz gorur g, Demir H (2022). Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. Turkish Journal of Medical Sciences, 52(6), 1745 - 1753. 10.55730/1300-0144.5519
Chicago	ISGOREN SERKAN,Köroğlu Gizem,daglioz gorur gozde,Demir Hakan Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. Turkish Journal of Medical Sciences 52, no.6 (2022): 1745 - 1753. 10.55730/1300-0144.5519
MLA	ISGOREN SERKAN,Köroğlu Gizem,daglioz gorur gozde,Demir Hakan Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. Turkish Journal of Medical Sciences, vol.52, no.6, 2022, ss.1745 - 1753. 10.55730/1300-0144.5519
AMA	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. Turkish Journal of Medical Sciences. 2022; 52(6): 1745 - 1753. 10.55730/1300-0144.5519
Vancouver	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination. Turkish Journal of Medical Sciences. 2022; 52(6): 1745 - 1753. 10.55730/1300-0144.5519
IEEE	ISGOREN S,Köroğlu G,daglioz gorur g,Demir H "Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination." Turkish Journal of Medical Sciences, 52, ss.1745 - 1753, 2022. 10.55730/1300-0144.5519
ISNAD	ISGOREN, SERKAN vd. "Evaluation of metabolic changes in FDG PET/CT imaging after mRNA-based COVID-19 vaccination". Turkish Journal of Medical Sciences 52/6 (2022), 1745-1753. https://doi.org/10.55730/1300-0144.5519