A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection

Yıl: 2022 Cilt: 52 Sayı: 6 Sayfa Aralığı: 1754 - 1761 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5520 İndeks Tarihi: 28-12-2022

A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection

Öz:
Background/aim: Data on antibody response following COVID-19 in kidney transplant recipients is scarce. This crosssectional study aims to investigate the antibody response to COVID-19 among kidney transplant recipients. Materials and methods: We recruited 46 kidney transplant recipients with RT-PCR-confirmed COVID-19 and 45 recipients without COVID-19 history. We also constructed two control groups (COVID-19 positive and negative) from a historical cohort of healthcare workers. We used age and sex-based propensity score matching to select the eligible subjects to the control groups. We measured the SARS-CoV-2 IgG levels quantitatively using the Abbott ARCHITECT system. An antibody level above 1.4 S/C was defined as positivity. Results: Transplant recipients with COVID-19 had a higher BMI, and COVID-19 history in a household member was more common than that of the transplant recipient without COVID-19. IgG seropositivity rate (69.6% vs. 78.3%, p = 0.238) and the median IgG level (3.28 [IQR: 0.80–5.85] vs. 4.59 [IQR: 1.61–6.06], p = 0.499) were similar in COVID-19-positive transplant recipients and controls. Kidney transplant recipients who had a longer duration between RT-PCR and antibody testing had lower antibody levels (r = –0.532, p < 0.001). Conclusion: At the early post-COVID-19 period, kidney transplant recipients have a similar antibody response to controls. However, these patients’ antibody levels and immunity should be closely monitored in the long term.
Anahtar Kelime: COVID-19 immune response immunosuppression kidney transplantation SARS-CoV-2 IgG antibody

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APA Dincer M, Eren N, MURT A, Yıldız N, özcan ş, ergül m, gökçay bek s, ATLI Z, TRABULUS S, DERVISOGLU E, DOGANAY H, Seyahi N (2022). A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. , 1754 - 1761. 10.55730/1300-0144.5520
Chicago Dincer Mevlüt Tamer,Eren Necmi,MURT Ahmet,Yıldız Nuriye,özcan şeyda gül,ergül metin,gökçay bek sibel,ATLI ZEYNEP,TRABULUS SINAN,DERVISOGLU ERKAN,DOGANAY HAMDI LEVENT,Seyahi Nurhan A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. (2022): 1754 - 1761. 10.55730/1300-0144.5520
MLA Dincer Mevlüt Tamer,Eren Necmi,MURT Ahmet,Yıldız Nuriye,özcan şeyda gül,ergül metin,gökçay bek sibel,ATLI ZEYNEP,TRABULUS SINAN,DERVISOGLU ERKAN,DOGANAY HAMDI LEVENT,Seyahi Nurhan A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. , 2022, ss.1754 - 1761. 10.55730/1300-0144.5520
AMA Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. . 2022; 1754 - 1761. 10.55730/1300-0144.5520
Vancouver Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. . 2022; 1754 - 1761. 10.55730/1300-0144.5520
IEEE Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N "A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection." , ss.1754 - 1761, 2022. 10.55730/1300-0144.5520
ISNAD Dincer, Mevlüt Tamer vd. "A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection". (2022), 1754-1761. https://doi.org/10.55730/1300-0144.5520
APA Dincer M, Eren N, MURT A, Yıldız N, özcan ş, ergül m, gökçay bek s, ATLI Z, TRABULUS S, DERVISOGLU E, DOGANAY H, Seyahi N (2022). A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. Turkish Journal of Medical Sciences, 52(6), 1754 - 1761. 10.55730/1300-0144.5520
Chicago Dincer Mevlüt Tamer,Eren Necmi,MURT Ahmet,Yıldız Nuriye,özcan şeyda gül,ergül metin,gökçay bek sibel,ATLI ZEYNEP,TRABULUS SINAN,DERVISOGLU ERKAN,DOGANAY HAMDI LEVENT,Seyahi Nurhan A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. Turkish Journal of Medical Sciences 52, no.6 (2022): 1754 - 1761. 10.55730/1300-0144.5520
MLA Dincer Mevlüt Tamer,Eren Necmi,MURT Ahmet,Yıldız Nuriye,özcan şeyda gül,ergül metin,gökçay bek sibel,ATLI ZEYNEP,TRABULUS SINAN,DERVISOGLU ERKAN,DOGANAY HAMDI LEVENT,Seyahi Nurhan A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. Turkish Journal of Medical Sciences, vol.52, no.6, 2022, ss.1754 - 1761. 10.55730/1300-0144.5520
AMA Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. Turkish Journal of Medical Sciences. 2022; 52(6): 1754 - 1761. 10.55730/1300-0144.5520
Vancouver Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection. Turkish Journal of Medical Sciences. 2022; 52(6): 1754 - 1761. 10.55730/1300-0144.5520
IEEE Dincer M,Eren N,MURT A,Yıldız N,özcan ş,ergül m,gökçay bek s,ATLI Z,TRABULUS S,DERVISOGLU E,DOGANAY H,Seyahi N "A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection." Turkish Journal of Medical Sciences, 52, ss.1754 - 1761, 2022. 10.55730/1300-0144.5520
ISNAD Dincer, Mevlüt Tamer vd. "A comparison of antibody response in kidney transplant recipients and healthcare workers who had PCR-confirmed COVID-19 infection". Turkish Journal of Medical Sciences 52/6 (2022), 1754-1761. https://doi.org/10.55730/1300-0144.5520