Yıl: 2022 Cilt: 13 Sayı: 3 Sayfa Aralığı: 475 - 484 Metin Dili: İngilizce DOI: 10.22312/sdusbed.1150492 İndeks Tarihi: 28-12-2022

Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation

Öz:
Objetive: The aim of the study was to develop thymol thermosensitive in situ gels based on poloxamers in order to prolong dental contact time, control drug release, and enhance dental bioavailability. Materials and Methods: Poloxamer 188 (P188) and poloxamer 407 (P407) were used in varying amounts to designed the in situ gels. Mucoadhesive excipient, like hydroxypropyl methylcellulose (HPMC), was transferred to the in situ gels to improve the formulation's ability to adhere to biological surfaces. For the created formulations, in vitro drug release, pH, clarity, and sol-gel transition temperature were all evaluated.Results: The all of in situ gels gelation temperatures of the developed formulations range from 33 to 37°C, pH values are around 7, and syringeability is defined as the amount of force necessary to discharge each formulation from a syringe fitted with a 20-gauge needle. The quantities of P407 and HPMC with the preparations, decreasing in vitro burst release while also increasing the viscosity but every in situ gel formulation releases for six hours. Conclusion:The results show that in situ gels containing P407 and P188 show promise for thymol dental application.
Anahtar Kelime: Thymol Poloxamer In Situ Gel Dental Drug Delivery System Hydroxypropyl methylcellulose

Timol Yüklü Diş İn Situ Jellerin Tasarımı; In Vitro Değerlendirilmesi

Öz:
Amaç: Bu çalışmanın amacı, dental temas süresini uzatmak, ilaç salımını kontrol etmek ve dental biyoyararlanımı arttırmak için poloksamerlere dayalı timol yüklü in situ jel formülasyonları geliştirmektir. Gereç ve Yöntem: İn situ jellerin tasarımında Poloksamer 188 (P188) ve Poloksamer 407 (P407) farklı oranlarda kullanılmıştır. Jelin biyolojik yüzeylere yapışma yeteneğini geliştirmek için formülasyonlara hidroksipropil metilselüloz (HPMC) gibi muko-yapışkan bir yardımcı madde eklenmiştir. Oluşturulan formülasyonlar için in vitro ilaç salımı, pH, berraklık ve sol-jel geçiş sıcaklığı değerlendirilmiştir. Bulgular: Geliştirilen formülasyonların jelleşme sıcaklıkları 33 ila 37°C arasında olduğu, pH değerlerinin yaklaşık 7 olduğu ve 20 numaralı iğne ile şırıngalanabilir olduğu görülmüştür. Preparat içerisindeki, P407 ve HPMC miktarları yükseldikçe, in vitro patlama salım azalırken aynı zamanda viskozitenin arttığı tespit edilmiştir, bütün in situ jel formülasyonlarının altı saat süre ile salım yaptığı belirlenmiştir. Sonuç: Sonuçlar, timol içeren P407 ve P188 in situ jellerin timol diş uygulaması için umut verici olduğunu göstermektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Polat H, GÖZCÜ S, akşit H (2022). Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. , 475 - 484. 10.22312/sdusbed.1150492
Chicago Polat Heybet Kerem,GÖZCÜ SEFA,akşit Hüseyin Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. (2022): 475 - 484. 10.22312/sdusbed.1150492
MLA Polat Heybet Kerem,GÖZCÜ SEFA,akşit Hüseyin Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. , 2022, ss.475 - 484. 10.22312/sdusbed.1150492
AMA Polat H,GÖZCÜ S,akşit H Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. . 2022; 475 - 484. 10.22312/sdusbed.1150492
Vancouver Polat H,GÖZCÜ S,akşit H Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. . 2022; 475 - 484. 10.22312/sdusbed.1150492
IEEE Polat H,GÖZCÜ S,akşit H "Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation." , ss.475 - 484, 2022. 10.22312/sdusbed.1150492
ISNAD Polat, Heybet Kerem vd. "Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation". (2022), 475-484. https://doi.org/10.22312/sdusbed.1150492
APA Polat H, GÖZCÜ S, akşit H (2022). Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 13(3), 475 - 484. 10.22312/sdusbed.1150492
Chicago Polat Heybet Kerem,GÖZCÜ SEFA,akşit Hüseyin Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 13, no.3 (2022): 475 - 484. 10.22312/sdusbed.1150492
MLA Polat Heybet Kerem,GÖZCÜ SEFA,akşit Hüseyin Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, vol.13, no.3, 2022, ss.475 - 484. 10.22312/sdusbed.1150492
AMA Polat H,GÖZCÜ S,akşit H Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2022; 13(3): 475 - 484. 10.22312/sdusbed.1150492
Vancouver Polat H,GÖZCÜ S,akşit H Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2022; 13(3): 475 - 484. 10.22312/sdusbed.1150492
IEEE Polat H,GÖZCÜ S,akşit H "Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation." Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, 13, ss.475 - 484, 2022. 10.22312/sdusbed.1150492
ISNAD Polat, Heybet Kerem vd. "Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation". Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi 13/3 (2022), 475-484. https://doi.org/10.22312/sdusbed.1150492