Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?

YENER, Ismail; Yiğitkan, Serkan; Ertaş, Abdulselam; Irtegun, Sevgi; hasimi, nesrin; Kolak, Ufuk; Fırat, Mehmet; OZHAN KOCAKAYA, SAFAK; Akdeniz, Mehmet

doi:10.55730/1300-0527.3494

Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?

Mehmet AKDENİZ, (Adli Tıp Kurumu, Diyarbakır Grup Başkanlığı, Diyarbakır, Türkiye)

İsmail YENER, (Dicle Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Diyarbakır, Türkiye)

Sevgi İRTEGÜN KANDEMİR, (Dicle Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Diyarbakır, Türkiye)

SAFAK OZHAN KOCAKAYA, (Dicle Üniversitesi, Fen Fakültesi, Organik Kimya Bölümü, Diyarbakır, Türkiye)

Mehmet FIRAT, (Van Yüzüncü Yıl Üniversitesi, Eğitim Fakültesi, Biyoloji Bölümü, Van, Türkiye)

Serkan YİĞİTKAN, (Dicle Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Diyarbakır, Türkiye)

nesrin hasimi, (Batman Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Batman, Türkiye)

Abdulselam ERTAŞ, (Dicle Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Diyarbakır, Türkiye)

Ufuk KOLAK (İstanbul Üniversitesi, Eczacılık Fakültesi, Genel ve Analitik Kimya Anabilim Dalı, İstanbul, Türkiye)

Turkish Journal of Chemistry

12 0

Yıl: 2022 Cilt: 46 Sayı: 6 Sayfa Aralığı: 1956 - 1971 Metin Dili: İngilizce DOI: 10.55730/1300-0527.3494 İndeks Tarihi: 30-12-2022

Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?

Öz:

The importance of Hypericum L. species, being used in traditional medicine, in the scientific world is increasing day by day. Hypericum species are plants that have been used in the treatment of many diseases for a long time and have healing properties. In the current study, the essential oil compositions of Hypericum scabrum L. and H. ternatum Poulter collected from different localities in Turkey were determined by GC-MS/FID. In addition, their antioxidant, cytotoxic, and antimicrobial activities with their enzyme inhibitory potentials (cholinesterase, urease, tyrosinase, elastase, and collagenase) were investigated. Also, in vitro and in silico studies of the major components of the species have been carried out on the studied enzymes. It was determined that four H. scabrum samples mainly contained α-pinene (55.99%–62.80%) while three H. ternatum samples contained 2-methyloctane (9.45%–22.39%) and α-pinene (12.75%–33.08%). While H. scabrum essential oils possessed significant biological activity potential except for the antimicrobial activity, H. ternatum samples did not. All essential oil samples of H. scabrum exhibited a high cytotoxic effect $(IC_{50}$ 21.67 ± 0.34 to 34.67 ± 0 .45 μg/mL) against colon cancer cell line (HT-29) and indicated higher acetyl- (Inhibiton% 83.30 ± 1.90 to 93.08 ± 1.04) and butyryl- cholinesterase (Inhibiton% 80.58 ± 1.19 to 93.28 ± 1.99) inhibitory activity than the standard compound, galantamine. Furthermore, all samples of H. scabrum showed high tyrosinase (Inhibiton% 69.00 ± 1.64 to 95.25 ± 1.42) and elastase (Inhibiton% 27.58 ± 0.34 to 36.69 ± 0.18) inhibitory effects. These biological activity results indicated that H. scabrum essential oil could be used in the cosmetic and pharmaceutical industries.

Anahtar Kelime: Hypericum ternatum Hypericum scabrum essential oils anticholinesterase antimicrobial molecular docking

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Akdeniz M, YENER I, Irtegun S, OZHAN KOCAKAYA S, Fırat M, Yiğitkan S, hasimi n, Ertaş A, Kolak U (2022). Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. , 1956 - 1971. 10.55730/1300-0527.3494
Chicago	Akdeniz Mehmet,YENER Ismail,Irtegun Sevgi,OZHAN KOCAKAYA SAFAK,Fırat Mehmet,Yiğitkan Serkan,hasimi nesrin,Ertaş Abdulselam,Kolak Ufuk Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. (2022): 1956 - 1971. 10.55730/1300-0527.3494
MLA	Akdeniz Mehmet,YENER Ismail,Irtegun Sevgi,OZHAN KOCAKAYA SAFAK,Fırat Mehmet,Yiğitkan Serkan,hasimi nesrin,Ertaş Abdulselam,Kolak Ufuk Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. , 2022, ss.1956 - 1971. 10.55730/1300-0527.3494
AMA	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. . 2022; 1956 - 1971. 10.55730/1300-0527.3494
Vancouver	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. . 2022; 1956 - 1971. 10.55730/1300-0527.3494
IEEE	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U "Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?." , ss.1956 - 1971, 2022. 10.55730/1300-0527.3494
ISNAD	Akdeniz, Mehmet vd. "Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?". (2022), 1956-1971. https://doi.org/10.55730/1300-0527.3494

APA	Akdeniz M, YENER I, Irtegun S, OZHAN KOCAKAYA S, Fırat M, Yiğitkan S, hasimi n, Ertaş A, Kolak U (2022). Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. Turkish Journal of Chemistry, 46(6), 1956 - 1971. 10.55730/1300-0527.3494
Chicago	Akdeniz Mehmet,YENER Ismail,Irtegun Sevgi,OZHAN KOCAKAYA SAFAK,Fırat Mehmet,Yiğitkan Serkan,hasimi nesrin,Ertaş Abdulselam,Kolak Ufuk Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. Turkish Journal of Chemistry 46, no.6 (2022): 1956 - 1971. 10.55730/1300-0527.3494
MLA	Akdeniz Mehmet,YENER Ismail,Irtegun Sevgi,OZHAN KOCAKAYA SAFAK,Fırat Mehmet,Yiğitkan Serkan,hasimi nesrin,Ertaş Abdulselam,Kolak Ufuk Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. Turkish Journal of Chemistry, vol.46, no.6, 2022, ss.1956 - 1971. 10.55730/1300-0527.3494
AMA	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. Turkish Journal of Chemistry. 2022; 46(6): 1956 - 1971. 10.55730/1300-0527.3494
Vancouver	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?. Turkish Journal of Chemistry. 2022; 46(6): 1956 - 1971. 10.55730/1300-0527.3494
IEEE	Akdeniz M,YENER I,Irtegun S,OZHAN KOCAKAYA S,Fırat M,Yiğitkan S,hasimi n,Ertaş A,Kolak U "Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?." Turkish Journal of Chemistry, 46, ss.1956 - 1971, 2022. 10.55730/1300-0527.3494
ISNAD	Akdeniz, Mehmet vd. "Determination of essential oil and biological activities of Hypericum ternatum Poulter and H. scabrum L. species collected from different localities: is H. scabrum an alternative to multifunctional species ST JOHN’S WORT (H. perforatum)?". Turkish Journal of Chemistry 46/6 (2022), 1956-1971. https://doi.org/10.55730/1300-0527.3494