OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS

DER, Fatma Gülay; Öngöz Dede, Figen; KILINC, Emrah; TAZEGÜL, KAAN; Bozkurt Doğan, Şeyma

OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS

Figen ÖNGÖZ DEDE, (Ordu Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Anabilim Dalı, Ordu, Türkiye)

Şeyma BOZKURT DOĞAN, (Yıldırım Beyazıt Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Anabilim Dalı, Ankara, Türkiye)

Kaan Tazegül, (Adana Yüreğir Karşıyaka Halk Ağız Sağlığı Merkezi, Periodontoloji Bölümü, Adana, Türkiye)

Fatma Gülay DER, (Ege Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, İzmir, Türkiye)

Emrah KILINC (Ege Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, İzmir, Türkiye)

Clinical Dentistry and Research

3 2

Yıl: 2022 Cilt: 46 Sayı: 3 Sayfa Aralığı: 147 - 155 Metin Dili: İngilizce İndeks Tarihi: 30-12-2022

OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS

Öz:

Background and Aims: The study aimed to investigate the oxidative DNA damage of three commercial mouthrinses Kloroben®, Listerine®, and Majezik® on oral mucosal tissues and peripheral blood of the rats. Materials and Method: Forty male Wistar rats were distributed into four groups: the control group orally treated with 0.5 mL of 0.9% NaCl, and three experimental groups orally treated with 0.5 mL of 1) 0.12% chlorhexidine digluconate and 0.15% Benzydamine HCl (Kloroben® group), 2) 4 essential oil containing (Listerine® group), and 3) 0.5g flurbiprofen (Majezik® group) twice daily, during14 days. At the end of the experimental period, rats were sacrificed, and then 5-(hydroxymethyl) uracil (5HMU) and 2-deoxyuridine (2dU) and 8-hydroxy-2-deoxyguanosine (8OHdG) in the oral mucosal tissues and peripheral blood were measured by Ultra Performance Liquid Chromatography (UPLC). Results: There were no significant differences in 5HMU, 2dU, and 8OHdG levels in rat oral mucosal tissue and peripheral blood between Kloroben®, Listerine®, Majezik®, and control groups for 14 days (P>.05). Conclusions: The present study could not observe the presence of oxidative DNA damage on oral mucosal tissues and peripheral

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APA	Öngöz Dede F, Bozkurt Doğan Ş, TAZEGÜL K, DER F, KILINC E (2022). OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. , 147 - 155.
Chicago	Öngöz Dede Figen,Bozkurt Doğan Şeyma,TAZEGÜL KAAN,DER Fatma Gülay,KILINC Emrah OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. (2022): 147 - 155.
MLA	Öngöz Dede Figen,Bozkurt Doğan Şeyma,TAZEGÜL KAAN,DER Fatma Gülay,KILINC Emrah OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. , 2022, ss.147 - 155.
AMA	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. . 2022; 147 - 155.
Vancouver	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. . 2022; 147 - 155.
IEEE	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E "OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS." , ss.147 - 155, 2022.
ISNAD	Öngöz Dede, Figen vd. "OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS". (2022), 147-155.

APA	Öngöz Dede F, Bozkurt Doğan Ş, TAZEGÜL K, DER F, KILINC E (2022). OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. Clinical Dentistry and Research, 46(3), 147 - 155.
Chicago	Öngöz Dede Figen,Bozkurt Doğan Şeyma,TAZEGÜL KAAN,DER Fatma Gülay,KILINC Emrah OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. Clinical Dentistry and Research 46, no.3 (2022): 147 - 155.
MLA	Öngöz Dede Figen,Bozkurt Doğan Şeyma,TAZEGÜL KAAN,DER Fatma Gülay,KILINC Emrah OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. Clinical Dentistry and Research, vol.46, no.3, 2022, ss.147 - 155.
AMA	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. Clinical Dentistry and Research. 2022; 46(3): 147 - 155.
Vancouver	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS. Clinical Dentistry and Research. 2022; 46(3): 147 - 155.
IEEE	Öngöz Dede F,Bozkurt Doğan Ş,TAZEGÜL K,DER F,KILINC E "OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS." Clinical Dentistry and Research, 46, ss.147 - 155, 2022.
ISNAD	Öngöz Dede, Figen vd. "OXIDATIVE DNA DAMAGE OF THREE COMMERCIAL MOUTHRINSES IN THE PERIPHERAL BLOODS AND ORAL MUCOSAL CELLS OF THE RATS". Clinical Dentistry and Research 46/3 (2022), 147-155.