Objective Inflammation-related hemogram parameters have recently started to be defined as a useful marker in cancer patients. In this study, we aimed to comparison of hemogram parameters in papillary thyroid cancer (PTC) patients, well differentiated thyroid tumor of uncertain malignant potential (WDT-UMP) and follicular adenoma (FA). Material and Method The 287 patients’ data were analyzed in study. Study subjects were divided into 5 different groups. 1st group: control, 2nd group: FA, 3rd group: WDT-UMP, 4th group: non-metastatic PTC, 5th group: metastatic PTC. We evaluated the preoperative blood tests. Results The average age was 50 (37-59). The mean TSH value was 1.2 (0.5-2.2) μIU/mL. The mean size of the lesion detected in the total thyroidectomy material was 1.7 (1.0-3.0) cm. White blood cells (WBC), neutrophils and lymphocytes were lower in 3rd group than 4th group (p<0.05). NLR was found to be similar in all groups with the control group (p=0.173). MPV was found to be statistically higher in the control patients (p=0.000). MPV was significantly higher in 2nd group compared to 3rd group and 4th group (p=0.001, p=0.016; respectively). RDW was significantly lower in the control group compared to all other groups (p=0.000). There was no correlation between tumor size and hemogram parameters. Conclusion In patients followed up for thyroid nodules, low MPV should raise a suspicion in terms of possible malignancy. Increased RDW may be useful in predicting thyroid nodule development. These easily accessible, cost-effective markers may support other diagnostic methods to distinguish malignant from benign nodules.