Effect of risk group on survival in non-Wilms' renal tumors in children
Yıl: 2022 Cilt: 47 Sayı: 4 Sayfa Aralığı: 1578 - 1583 Metin Dili: İngilizce DOI: 10.17826/cumj.1166854 İndeks Tarihi: 09-01-2023
Effect of risk group on survival in non-Wilms' renal tumors in children
Öz: Purpose: The aim of this study was to evaluate tne effect of the risk group on the clinical features of the disease, treatment strategies and especially survival in children with Non-Wilms’ renal tumors (NWRTs). Materials and Methods: Patients diagnosed with NWRTs followed up and treated between January 2012 and January 2022 were included in the study (n=29; 16 boys and 13 girls). They were categorized into high- and low-risk groups based on their histological type. Patient records were reviewed retrospectively. Clinical characteristics, treatments, and outcomes of these patients were analyzed. Results: The high-risk group comprised clear cell sarcoma (CCSK) (n=8, 27.6%), malignant rhabdoid tumor (MRT) (n=3, 10.3%), renal cell carcinoma (n=2, 6.9%), non-Hodgkin lymphoma (n=1, 3.4%), and primitive neuroectodermal tumor (PNET) (n=1, 4%). The low-risk group comprised congenital mesoblastic nephroma (CMN) (n=9, 31%), angiomyolipoma (n=4, 3.8%), and hemangioma (n=1, 3.4%). Five patients died due to disease progression (mortality rate, 17%), all of whom belonged to the high-risk group (three patients with MRT, one with CCSK, one with PNET). The 5-year survival rate was 72% for the high risk group and 100% for the low risk group. Conclusion: Although low-risk tumors are associated with excellent outcomes, the outcomes vary in high-risk tumors. Physicians should be wary of high mortality rates in children with MRT, CCSK, and PNET, and should design multidisciplinary treatments for NWRTs.
Anahtar Kelime: Çocuklarda Wilms tümörü dışındaki böbrek tümörlerinde risk grubunun sağkalıma etkisi
Öz: Amaç: Bu çalışmanın amacı Wilms tümörü dışındaki böbrek tümörleri (WDBT'leri) olan risk grubunun hastalığın klinik özelliklerini, tedavi stratejilerini ve özellikle sağkalımı etkilerini değerlendirmektir.3323 Gereç ve Yöntem: Ocak 2012 ile Ocak 2022 tarihleri arasında takip WDBT tanısı ile takip ve tedavi edilen hastalar çalışmaya dahil edildi (n=29; 16 erkek ve 13 kız). Hastalar, histolojik tiplerine göre yüksek ve düşük risk grubu olarak kategorize edildi. Tüm hastaların dosya kayıtları geriye dönük olarak incelendi. Hastaların klinik özellikleri, uygulanan tedaviler ve tedavi sonuçları analiz edildi. Bulgular: Yüksek risk grubundaki hastalar; berrak hücreli sarkom (BHS) (n=8, %27,6), malign rabdoid tümör (MRT) (n=3, %10,3), renal hücreli karsinom (RHK) (n=2, %6,9), Hodgkin-dışı lenfoma (HDL) (n=1, %3,4), primitif nöroektodermal tümör (PNET) (n=1, %4) iken, düşük risk grubundaki hastalar; konjenital mezoblastik nefroma (KMN) (n=9, %31), anjiomiyolipom (n=4, %3,8) ve hemanjiom (n=1, %3,4) olarak saptandı. WDBT’li 29 hastadan 5’i progresif hastalık nedeniyle kaybedildi; ölüm oranı %17 idi (n=5) ve kaybedilen tüm hastalar yüksek risk grubunda idi (3 hasta MRT, 1 hasta BHS, 1 hasta PNET). 5 yıllık sağkalım oranı yüksek risk grubu için %72, düşük risk grubu için %100 olarak saptandı. Sonuç: Düşük riskli tümörler, mükemmel sonuçlarla ilişkilendirilirken, yüksek riskli tümörler değişken bir sonuca sahiptir. MRT, BHS ve PNET'li çocuklarda yüksek ölüm oranlarına karşı dikkatli olmalı ve WDBT'ler için multidisipliner tedavi planları tasarlanmalıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ozkan A, BAYRAM İ, tutus k, Sezgin G, Erdogan S, Küpeli S (2022). Effect of risk group on survival in non-Wilms' renal tumors in children. , 1578 - 1583. 10.17826/cumj.1166854 |
| Chicago | Ozkan Ayse,BAYRAM İBRAHİM,tutus kamuran,Sezgin Gülay,Erdogan Seyda,Küpeli Serhan Effect of risk group on survival in non-Wilms' renal tumors in children. (2022): 1578 - 1583. 10.17826/cumj.1166854 |
| MLA | Ozkan Ayse,BAYRAM İBRAHİM,tutus kamuran,Sezgin Gülay,Erdogan Seyda,Küpeli Serhan Effect of risk group on survival in non-Wilms' renal tumors in children. , 2022, ss.1578 - 1583. 10.17826/cumj.1166854 |
| AMA | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S Effect of risk group on survival in non-Wilms' renal tumors in children. . 2022; 1578 - 1583. 10.17826/cumj.1166854 |
| Vancouver | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S Effect of risk group on survival in non-Wilms' renal tumors in children. . 2022; 1578 - 1583. 10.17826/cumj.1166854 |
| IEEE | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S "Effect of risk group on survival in non-Wilms' renal tumors in children." , ss.1578 - 1583, 2022. 10.17826/cumj.1166854 |
| ISNAD | Ozkan, Ayse vd. "Effect of risk group on survival in non-Wilms' renal tumors in children". (2022), 1578-1583. https://doi.org/10.17826/cumj.1166854 |
| APA | Ozkan A, BAYRAM İ, tutus k, Sezgin G, Erdogan S, Küpeli S (2022). Effect of risk group on survival in non-Wilms' renal tumors in children. Cukurova Medical Journal, 47(4), 1578 - 1583. 10.17826/cumj.1166854 |
| Chicago | Ozkan Ayse,BAYRAM İBRAHİM,tutus kamuran,Sezgin Gülay,Erdogan Seyda,Küpeli Serhan Effect of risk group on survival in non-Wilms' renal tumors in children. Cukurova Medical Journal 47, no.4 (2022): 1578 - 1583. 10.17826/cumj.1166854 |
| MLA | Ozkan Ayse,BAYRAM İBRAHİM,tutus kamuran,Sezgin Gülay,Erdogan Seyda,Küpeli Serhan Effect of risk group on survival in non-Wilms' renal tumors in children. Cukurova Medical Journal, vol.47, no.4, 2022, ss.1578 - 1583. 10.17826/cumj.1166854 |
| AMA | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S Effect of risk group on survival in non-Wilms' renal tumors in children. Cukurova Medical Journal. 2022; 47(4): 1578 - 1583. 10.17826/cumj.1166854 |
| Vancouver | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S Effect of risk group on survival in non-Wilms' renal tumors in children. Cukurova Medical Journal. 2022; 47(4): 1578 - 1583. 10.17826/cumj.1166854 |
| IEEE | Ozkan A,BAYRAM İ,tutus k,Sezgin G,Erdogan S,Küpeli S "Effect of risk group on survival in non-Wilms' renal tumors in children." Cukurova Medical Journal, 47, ss.1578 - 1583, 2022. 10.17826/cumj.1166854 |
| ISNAD | Ozkan, Ayse vd. "Effect of risk group on survival in non-Wilms' renal tumors in children". Cukurova Medical Journal 47/4 (2022), 1578-1583. https://doi.org/10.17826/cumj.1166854 |
