Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

ACAR ÇEVİK, ULVİYE; Bostancı, Hayrani Eren

doi:10.17776/csj.1131485

Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

Hayrani Eren BOSTANCI, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Sivas, Türkiye)

Ulviye ÇEVİK (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Eskişehir, Türkiye)

Cumhuriyet Science Journal

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Yıl: 2022 Cilt: 43 Sayı: 4 Sayfa Aralığı: 590 - 593 Metin Dili: İngilizce DOI: 10.17776/csj.1131485 İndeks Tarihi: 09-01-2023

Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors

Öz:

In this study, imidazole derivative compounds were synthesized using the Debus-Radziszewski method. The chemical structures of the compounds were characterized by spectroscopic methods. The effects of target compounds on MCF7 (CRL-3435) were examined and their IC50 values and percent viability were calculated. In addition, the cytotoxic effects on the L929 (CCL-1) normal cell line were evaluated in order to determine the selectivities of the compounds. Then, the inhibition values of aromatase enzyme of the compounds were calculated and compared to the reference compound. When the results were examined, it was observed that Compound la caused the death of breast cancer cells, although not as much as cisplatin, but did not harm healthy cells. In this respect, it was determined that compound Ia has a promising anticancer effect as an aromatase inhibitor.

Anahtar Kelime: İmidazole MTT Anticancer Aromatase

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Bostancı H, ACAR ÇEVİK U (2022). Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. , 590 - 593. 10.17776/csj.1131485
Chicago	Bostancı Hayrani Eren,ACAR ÇEVİK ULVİYE Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. (2022): 590 - 593. 10.17776/csj.1131485
MLA	Bostancı Hayrani Eren,ACAR ÇEVİK ULVİYE Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. , 2022, ss.590 - 593. 10.17776/csj.1131485
AMA	Bostancı H,ACAR ÇEVİK U Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. . 2022; 590 - 593. 10.17776/csj.1131485
Vancouver	Bostancı H,ACAR ÇEVİK U Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. . 2022; 590 - 593. 10.17776/csj.1131485
IEEE	Bostancı H,ACAR ÇEVİK U "Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors." , ss.590 - 593, 2022. 10.17776/csj.1131485
ISNAD	Bostancı, Hayrani Eren - ACAR ÇEVİK, ULVİYE. "Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors". (2022), 590-593. https://doi.org/10.17776/csj.1131485

APA	Bostancı H, ACAR ÇEVİK U (2022). Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal, 43(4), 590 - 593. 10.17776/csj.1131485
Chicago	Bostancı Hayrani Eren,ACAR ÇEVİK ULVİYE Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal 43, no.4 (2022): 590 - 593. 10.17776/csj.1131485
MLA	Bostancı Hayrani Eren,ACAR ÇEVİK ULVİYE Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal, vol.43, no.4, 2022, ss.590 - 593. 10.17776/csj.1131485
AMA	Bostancı H,ACAR ÇEVİK U Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal. 2022; 43(4): 590 - 593. 10.17776/csj.1131485
Vancouver	Bostancı H,ACAR ÇEVİK U Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors. Cumhuriyet Science Journal. 2022; 43(4): 590 - 593. 10.17776/csj.1131485
IEEE	Bostancı H,ACAR ÇEVİK U "Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors." Cumhuriyet Science Journal, 43, ss.590 - 593, 2022. 10.17776/csj.1131485
ISNAD	Bostancı, Hayrani Eren - ACAR ÇEVİK, ULVİYE. "Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors". Cumhuriyet Science Journal 43/4 (2022), 590-593. https://doi.org/10.17776/csj.1131485