TY  - JOUR
TI  - Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors
AB  - In this study, imidazole derivative compounds were synthesized using the Debus-Radziszewski method. The chemical structures of the compounds were characterized by spectroscopic methods. The effects of target compounds on MCF7 (CRL-3435) were examined and their IC50 values and percent viability were calculated. In addition, the cytotoxic effects on the L929 (CCL-1) normal cell line were evaluated in order to determine the selectivities of the compounds. Then, the inhibition values of aromatase enzyme of the compounds were calculated and compared to the reference compound. When the results were examined, it was observed that Compound la caused the death of breast cancer cells, although not as much as cisplatin, but did not harm healthy cells. In this respect, it was determined that compound Ia has a promising anticancer effect as an aromatase inhibitor.
AU  - ACAR ÇEVİK, ULVİYE
AU  - Bostancı, Hayrani Eren
DO  - 10.17776/csj.1131485
PY  - 2022
JO  - Cumhuriyet Science Journal
VL  - 43
IS  - 4
SN  - 2587-2680
SP  - 590
EP  - 593
DB  - TRDizin
UR  - http://search/yayin/detay/1149859
ER  -