Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

Beyzanur ÖZDEMİR, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Sivas, Türkiye)
Halil İbrahim ULUSOY, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Sivas, Türkiye)
Ümmügülsüm MORGÜL, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Sivas, Türkiye)
Marcello LOCATELLİ, (Department of Pharmacy, University of Chieti–Pescara “G. d’Annunzio”, Via dei Vestini 31, Chieti 66100, Italy)
Abuzar KABİR (Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA)
Cumhuriyet Science Journal
3 0
Yıl: 2022 Cilt: 43 Sayı: 4 Sayfa Aralığı: 600 - 605 Metin Dili: İngilizce DOI: 10.17776/csj.1182848 İndeks Tarihi: 09-01-2023

Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction

Öz:
This study is focused on developing a sensitive analytical method for Venlafaxine molecule which is antidepressant drug belonging to the serotonin-noradrenaline reuptake inhibitors (SNRI) group. With this study, a separation and preconcentration method based on fabric phase sorptive extraction(FPSE) method was developed for low levels of Venlafaxine in urine samples. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. The linearity of method under optimized conditions is in the range of 15.00-750.00 ng mL-1 while limit of detection is 4.28 ng mL-1. The relative standard deviation (RSD %) obtained from model solutions containing 300 ng mL-1 of Venlafaxine was lower than 3.1 % and pre-concentration factor was calculated as 62.50 for target molecule. In order to test accuracy of the method, recovery tests were carried out by means of spiked urine samples. As a result of recovery tests, quantative values were obtained in the range of 97.5-104.2 % successively.
Anahtar Kelime: HPLC Fabric phase sorptive extraction Venlafaxine Analytical method development

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Özdemir B, Ulusoy H, Morgül Ü, Locatelli M, Kabir A (2022). Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. , 600 - 605. 10.17776/csj.1182848
Chicago Özdemir Beyzanur,Ulusoy Halil İbrahim,Morgül Ümmügülsüm,Locatelli Marcello,Kabir Abuzar Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. (2022): 600 - 605. 10.17776/csj.1182848
MLA Özdemir Beyzanur,Ulusoy Halil İbrahim,Morgül Ümmügülsüm,Locatelli Marcello,Kabir Abuzar Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. , 2022, ss.600 - 605. 10.17776/csj.1182848
AMA Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. . 2022; 600 - 605. 10.17776/csj.1182848
Vancouver Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. . 2022; 600 - 605. 10.17776/csj.1182848
IEEE Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A "Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction." , ss.600 - 605, 2022. 10.17776/csj.1182848
ISNAD Özdemir, Beyzanur vd. "Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction". (2022), 600-605. https://doi.org/10.17776/csj.1182848
APA Özdemir B, Ulusoy H, Morgül Ü, Locatelli M, Kabir A (2022). Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal, 43(4), 600 - 605. 10.17776/csj.1182848
Chicago Özdemir Beyzanur,Ulusoy Halil İbrahim,Morgül Ümmügülsüm,Locatelli Marcello,Kabir Abuzar Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal 43, no.4 (2022): 600 - 605. 10.17776/csj.1182848
MLA Özdemir Beyzanur,Ulusoy Halil İbrahim,Morgül Ümmügülsüm,Locatelli Marcello,Kabir Abuzar Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal, vol.43, no.4, 2022, ss.600 - 605. 10.17776/csj.1182848
AMA Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal. 2022; 43(4): 600 - 605. 10.17776/csj.1182848
Vancouver Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction. Cumhuriyet Science Journal. 2022; 43(4): 600 - 605. 10.17776/csj.1182848
IEEE Özdemir B,Ulusoy H,Morgül Ü,Locatelli M,Kabir A "Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction." Cumhuriyet Science Journal, 43, ss.600 - 605, 2022. 10.17776/csj.1182848
ISNAD Özdemir, Beyzanur vd. "Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction". Cumhuriyet Science Journal 43/4 (2022), 600-605. https://doi.org/10.17776/csj.1182848
Sayfa Oluşturulma Tarihi
24-04-2024 18:45

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