TY  - JOUR
TI  - Sensitive Determination of Venlafaxine in Urine Samples by Using HPLC-DAD System After Fabric Phase Sorptive Extraction
AB  - This study is focused on developing a sensitive analytical method for Venlafaxine molecule which is antidepressant drug belonging to the serotonin-noradrenaline reuptake inhibitors (SNRI) group. With this study, a separation and preconcentration method based on fabric phase sorptive extraction(FPSE) method was developed for low levels of Venlafaxine in urine samples.  Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. The linearity of method under optimized conditions is in the range of 15.00-750.00 ng mL-1 while limit of detection is 4.28 ng mL-1. The relative standard deviation (RSD %) obtained from model solutions containing 300 ng mL-1 of Venlafaxine was lower than 3.1 % and pre-concentration factor was calculated as 62.50 for target molecule. In order to test accuracy of the method, recovery tests were carried out by means of spiked urine samples. As a result of recovery tests, quantative values were obtained in the range of 97.5-104.2 % successively.
AU  - Kabir, Abuzar
AU  - Özdemir, Beyzanur
AU  - Ulusoy, Halil İbrahim
AU  - Locatelli, Marcello
AU  - Morgül, Ümmügülsüm
DO  - 10.17776/csj.1182848
PY  - 2022
JO  - Cumhuriyet Science Journal
VL  - 43
IS  - 4
SN  - 2587-2680
SP  - 600
EP  - 605
DB  - TRDizin
UR  - http://search/yayin/detay/1149861
ER  -