Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines
Yıl: 2022 Cilt: 43 Sayı: 4 Sayfa Aralığı: 629 - 633 Metin Dili: İngilizce DOI: 10.17776/csj.1173347 İndeks Tarihi: 09-01-2023
Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines
Öz: In this study, four stages were used to create brand-new p-tert-butyl-calix [4] arene Schiff base derivatives. First, p-tert-butyl-phenol and formaldehyde are reacted to create p-tert-butyl-calix [4] arene (1). In the following step, methyl bromoacetate and p-ter-butyl-calix [4] arene (1) were combined with acetone and reflux to create the p-tert-butyl-calix [4] arene diester complex (2). The third step involves reacting the diester compound (2) and hydrazine hydrate to create the p-tert-butyl-calix [4] arene hydrazinamide molecule (3). In the final stage, calix [4] arene Schiff base derivatives (4a-d) were produced in good yields by combining compound (3), p-tert-butyl-calix [4] arene hydrazinamide, and various aldehyde derivatives with reflux in EtOH. Through the use of 1H-NMR, 13C-NMR, infrared spectroscopy, and elemental analysis, the structures of produced compounds were verified. Four distinct cancer lines are linked to the antitumor activity of synthetic chemicals. (HT-29, a human colon cancer cell line, PC-3, a human prostate cancer cell line, C6, a rat glioma cell line and MCF-7, a human breast cancer cell line). Weak antitumor activity was seen in synthetic substances. However, only compound 4b was found to have potential efficacy against C6 and HT-29. It is clear that compound 4b, which has a nitro substitute on the phenyl ring, draws attention due to its increased activity.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ISIK A, Uçar Çifçi K, Bostancı H, TUTAR Y, KOCAK A, YILMAZ M (2022). Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. , 629 - 633. 10.17776/csj.1173347 |
| Chicago | ISIK Aysen,Uçar Çifçi Kezban,Bostancı Hayrani Eren,TUTAR Yusuf,KOCAK AHMET,YILMAZ Mustafa Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. (2022): 629 - 633. 10.17776/csj.1173347 |
| MLA | ISIK Aysen,Uçar Çifçi Kezban,Bostancı Hayrani Eren,TUTAR Yusuf,KOCAK AHMET,YILMAZ Mustafa Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. , 2022, ss.629 - 633. 10.17776/csj.1173347 |
| AMA | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. . 2022; 629 - 633. 10.17776/csj.1173347 |
| Vancouver | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. . 2022; 629 - 633. 10.17776/csj.1173347 |
| IEEE | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M "Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines." , ss.629 - 633, 2022. 10.17776/csj.1173347 |
| ISNAD | ISIK, Aysen vd. "Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines". (2022), 629-633. https://doi.org/10.17776/csj.1173347 |
| APA | ISIK A, Uçar Çifçi K, Bostancı H, TUTAR Y, KOCAK A, YILMAZ M (2022). Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. Cumhuriyet Science Journal, 43(4), 629 - 633. 10.17776/csj.1173347 |
| Chicago | ISIK Aysen,Uçar Çifçi Kezban,Bostancı Hayrani Eren,TUTAR Yusuf,KOCAK AHMET,YILMAZ Mustafa Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. Cumhuriyet Science Journal 43, no.4 (2022): 629 - 633. 10.17776/csj.1173347 |
| MLA | ISIK Aysen,Uçar Çifçi Kezban,Bostancı Hayrani Eren,TUTAR Yusuf,KOCAK AHMET,YILMAZ Mustafa Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. Cumhuriyet Science Journal, vol.43, no.4, 2022, ss.629 - 633. 10.17776/csj.1173347 |
| AMA | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. Cumhuriyet Science Journal. 2022; 43(4): 629 - 633. 10.17776/csj.1173347 |
| Vancouver | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines. Cumhuriyet Science Journal. 2022; 43(4): 629 - 633. 10.17776/csj.1173347 |
| IEEE | ISIK A,Uçar Çifçi K,Bostancı H,TUTAR Y,KOCAK A,YILMAZ M "Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines." Cumhuriyet Science Journal, 43, ss.629 - 633, 2022. 10.17776/csj.1173347 |
| ISNAD | ISIK, Aysen vd. "Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines". Cumhuriyet Science Journal 43/4 (2022), 629-633. https://doi.org/10.17776/csj.1173347 |
