TY  - JOUR
TI  - Quercetin particles with lower inhibitory activity for α-glycosidase and negligible effects on blood clotting
AB  - Poly(quercetin) (p(QR)) particles was synthesis by using poly(ethylene glycol) diglycidyl ether (PEGGE) crosslinker in a single step via microemulsion system. The morphological, size and functional analysis of the prepared particles were carried by optic microscope, scanning electron microscope (SEM), dynamic light scattering (DLS) measurements and FT-IR spectroscopy. P(QR) particles were found to be in spherical shape with 372±9 nm size range by means of SEM images and DLS measurements. The zeta potential measurements, performed at different pH conditions and potentiometric titration of p(QR) particles were revealed that the isoelectric point and pKa values of as around pH 2.5 and 2.3, respectively. Ferric reducing antioxidant power (FRAP) was determined for QR and p(QR) particles at pH 3.6 and found as 9.4 and 0.43 µg reduced Fe(ll). The effects of QR and p(QR) particles on alfa-glycosidase enzyme activity at pH 6.9 were investigated and found that QR molecules and p(QR) particles were capable of inhibiting the α-glycosidase enzyme 89.3% and 24.7% respectively. The fluorescence spectroscopy of QR and p(QR) in fibrinogen showed that p(QR) particles do not induce clothing of blood.
AU  - Sagbas Suner, Selin
AU  - sahiner, mehtap
DO  - 10.18596/jotcsa.825868
PY  - 2021
JO  - Journal of the Turkish Chemical Society, Section A: Chemistry
VL  - 8
IS  - 2
SN  - 2149-0120
SP  - 443
EP  - 452
DB  - TRDizin
UR  - http://search/yayin/detay/1150710
ER  -