Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme

Levent, Serkan; Gul, Halise Inci; Demir, Yeliz; Yamali, Cem

doi:10.18596/jotcsa.842465

Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme

Cem YAMALİ, (Çukurova Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Anabilim Dalı, Adana, Türkiye)

Halise Inci GUL, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Erzurum, Türkiye)

Serkan LEVENT, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Eskişehir, Türkiye)

Yeliz DEMİR (Ardahan Üniversitesi, Nihat Delibalta Göle Meslek Yüksekokulu, Eczacılık Hizmetleri Anabilim Dalı, Ardahan, Türkiye)

Journal of the Turkish Chemical Society, Section A: Chemistry

5 1

Yıl: 2021 Cilt: 8 Sayı: 2 Sayfa Aralığı: 429 - 434 Metin Dili: İngilizce DOI: 10.18596/jotcsa.842465 İndeks Tarihi: 10-01-2023

Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme

Öz:

Alzheimer's disease is one of the diseases which is identified by progressive memory loss and cognitive deficits leading to a decline in the lifespan of the patients. The drugs used in the clinic show palliative properties and they are unable to modify disease progression. In this study, N-(4-(N-(diaminomethylene)sulfamoyl)phenyl)-2-(substituted-benzamido)benzamide derivatives were synthesized and evaluated towards acetylcholinesterase (AChE, E.C.3.1.1.7) enzyme which is the most studied enzyme regarding Alzheimer's disease. The inhibition constants (Ki) of the compounds synthesized towards the AChE enzyme were in the range of 15.51 ± 1.88 - 41.24 ± 10.13 nM. The most effective compound with the lowest Ki = 15.51 ± 1.88 nM, 2-benzamido-N-(4-(N-(diaminomethylene)sulfamoyl)phenyl)benzamide 6, can be reported as a lead compound of this study. Bioactivity results obtained by this study may provide useful information on the development of novel and potent inhibitors targeting Alzheimer's disease.

Anahtar Kelime: Acetylcholinesterase sulfaguanidine Alzheimer's disease

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yamali C, Gul H, Levent S, Demir Y (2021). Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. , 429 - 434. 10.18596/jotcsa.842465
Chicago	Yamali Cem,Gul Halise Inci,Levent Serkan,Demir Yeliz Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. (2021): 429 - 434. 10.18596/jotcsa.842465
MLA	Yamali Cem,Gul Halise Inci,Levent Serkan,Demir Yeliz Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. , 2021, ss.429 - 434. 10.18596/jotcsa.842465
AMA	Yamali C,Gul H,Levent S,Demir Y Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. . 2021; 429 - 434. 10.18596/jotcsa.842465
Vancouver	Yamali C,Gul H,Levent S,Demir Y Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. . 2021; 429 - 434. 10.18596/jotcsa.842465
IEEE	Yamali C,Gul H,Levent S,Demir Y "Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme." , ss.429 - 434, 2021. 10.18596/jotcsa.842465
ISNAD	Yamali, Cem vd. "Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme". (2021), 429-434. https://doi.org/10.18596/jotcsa.842465

APA	Yamali C, Gul H, Levent S, Demir Y (2021). Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. Journal of the Turkish Chemical Society, Section A: Chemistry, 8(2), 429 - 434. 10.18596/jotcsa.842465
Chicago	Yamali Cem,Gul Halise Inci,Levent Serkan,Demir Yeliz Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. Journal of the Turkish Chemical Society, Section A: Chemistry 8, no.2 (2021): 429 - 434. 10.18596/jotcsa.842465
MLA	Yamali Cem,Gul Halise Inci,Levent Serkan,Demir Yeliz Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. Journal of the Turkish Chemical Society, Section A: Chemistry, vol.8, no.2, 2021, ss.429 - 434. 10.18596/jotcsa.842465
AMA	Yamali C,Gul H,Levent S,Demir Y Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. Journal of the Turkish Chemical Society, Section A: Chemistry. 2021; 8(2): 429 - 434. 10.18596/jotcsa.842465
Vancouver	Yamali C,Gul H,Levent S,Demir Y Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme. Journal of the Turkish Chemical Society, Section A: Chemistry. 2021; 8(2): 429 - 434. 10.18596/jotcsa.842465
IEEE	Yamali C,Gul H,Levent S,Demir Y "Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme." Journal of the Turkish Chemical Society, Section A: Chemistry, 8, ss.429 - 434, 2021. 10.18596/jotcsa.842465
ISNAD	Yamali, Cem vd. "Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme". Journal of the Turkish Chemical Society, Section A: Chemistry 8/2 (2021), 429-434. https://doi.org/10.18596/jotcsa.842465