Kronik Yorgunluk Sendromu Beslenme İlişkisi

Onur, Aslı

doi:10.33076/2022.BDD.1680

Kronik Yorgunluk Sendromu Beslenme İlişkisi

Aslı Onur (Erciyes Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Kayseri, Türkiye)

Beslenme ve Diyet Dergisi

54 19

Yıl: 2022 Cilt: 50 Sayı: 3 Sayfa Aralığı: 103 - 111 Metin Dili: Türkçe DOI: 10.33076/2022.BDD.1680 İndeks Tarihi: 13-01-2023

Kronik Yorgunluk Sendromu Beslenme İlişkisi

Öz:

Kronik yorgunluk sendromu (KYS); eğitimsel, mesleki, sosyal veya kişisel faaliyetlerde yorgunluğa ve uzun süreli sakatlığa neden olan sistemik multifaktöryel bir hastalıktır. Bu hastalığın tanı ve tedavisi, semptomlarının fazla olmasından, tanı testlerinin ve kesin bir tedavi yönteminin olmamasından dolayı zordur. Tedaviler genellikle doktorlar tarafından semptom bazlı olarak önerilmektedir. Bunun yanında semptomatik tedavide beslenmenin önemi artmaktadır. Bazı besin ögesi eksikliklerinin, KYS’nin semptomlarının alevlenmesinde etkisi olduğu bildirilmektedir. Besin ögesi eksiklikleri KYS’nin klinik belirtilerine katkıda bulunduğu gibi iyileşme sürecinin uzamasına da neden olur. Beslenmede yapılacak değişiklikler ve besin desteği kullanımının KYS’nin iyileşmesinde etkili olabileceği düşünülmektedir. Yapılan çalışmalarda, besinlerin terapötik yararları görülmektedir. Bu nedenle, KYS’li hastaların beslenme durumlarının değerlendirilip, eksikliği görülen besin ögelerinin yerine konması gerekmektedir. Bu derleme makalede, KYS’de vitamin-mineral yetersizlikleri ile besin takviyelerinin potansiyel faydaları hakkında bilgi vermek amaçlanmıştır.

Anahtar Kelime: Miyaljik ensefalomiyelit kronik yorgunluk sendromu beslenme besin takviyesi

Nutritional Relationship with Chronic Fatigue Syndrome

Öz:

Chronic fatigue syndrome (CFS) is a multifactorial disease that causes fatigue and long-term disability in educational, occupational, social, and personal activities. Diagnosis and treatment of this disease is difficult due to its many symptoms, lack of diagnostic tests, and a definitive treatment method. Treatments are usually recommended by medical doctors on a symptom-based basis. In addition, the importance of nutrition in symptomatic treatment is increasing. It has been reported that some nutrient deficiencies have an effect on the exacerbation of the symptoms of CFS. Nutrient deficiencies are likely not only contribute to the clinical manifestations of CFS but also impair the healing process. It is thought that the changes to be made in the diet and the use of food supplements may be effective in the improvement of CFS. Studies have shown the therapeutic benefits of nutrients. For this reason, patients with CFS should be evaluated in terms of nutrition and nutrients that are deficient should be replaced. In this review article, it is aimed to provide information about vitamin-mineral deficiencies and the potential benefits of food supplementation in CFS.

Anahtar Kelime: Myalgic encephalomyelitis chronic fatigue syndrome nutrition food supplement

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Campagnolo N, Johnston S, Collatz A, Staines D, Marshall- Gradisnik S. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/ myalgic encephalomyelitis: A systematic review. J Hum Nutr Diet. 2017;30(3):247-59.
2. Bjørklund G, Dadar M, Pen JJ, Chirumbolo S, Aaseth J. Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach. Biomed Pharmacother. 2019;109:1000-7.
3. Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, et al. Chronic fatigue syndrome: A working case definition. Ann Intern Med. 1988;108(3):387-9.
4. Hyde B, Goldstein J, Levine P. The Clinical and scientific basis of myalgic encephalomyelitis. Chronic Fatigue Syndr. 1992;8(3):185-9.
5. Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, et al. Myalgic encephalomyelitis: International consensus criteria. J Intern Med. 2011;270(4):327-38.
6. Holgate ST, Komaroff AL, Mangan D, Wessely S. Chronic fatigue syndrome: Understanding a complex illness. Nat Rev Neurosci. 2011;12(9):539-44.
7. Clayton EW. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: An IOM report on redefining an illness. JAMA. 2015;313(11):1101-2.
8. Carruthers BM. Definitions and aetiology of myalgic encephalomyelitis: How the Canadian consensus clinical definition of myalgic encephalomyelitis works. J Clin Pathol. 2007;60(2):117-9.
9. Bateman L, Bested AC, Bonilla HF, Chheda B V, Chu L, Curtin JM, vd. Myalgic encephalomyelitis/chronic fatigue syndrome: Essentials of diagnosis and management. Mayo Clin Proc. 2021;96(11):2861-78.
10. Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020; 18(1):100.
11. Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications? J Gastroenterology. 2002;122(4):1140-56.
12. Eyskens JB, Illegems J, De Nil L, Nijs J, Kampen JK, Moorkens G. Assessing chronic fatigue syndrome: Self- reported physical functioning and correlations with physical testing. J Bodyw Mov Ther. 2019;23(3):598-603.
13. Newberry F, Hsieh S-Y, Wileman T, Carding SR. Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome? Clin Sci. 2018;132(5):523-42.
14. Shao C, Song J, Zhao S, Jiang H, Wang B, Chi A. Therapeutic effect and metabolic mechanism of a selenium- polysaccharide from ziyang green tea on chronic fatigue syndrome. Polymers (Basel). 2018;10(11):1269-86.
15. Nacul L, O’Boyle S, Palla L, Nacul FE, Mudie K, Kingdon CC, et al. How myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) progresses: The natural history of ME/CFS. Front Neurol. 2020;11:826.
16. Maric D, Brkic S, Mikic AN, Tomic S, Cebovic T, Turkulov V. Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit Int Med J Exp Clin Res. 2014;20:47-53.
17. Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: Peripheral and central mechanisms as therapeutic targets? Expert Opinion on Therapeutic Targets. 2013;17(9):1081-9.
18. Haß U, Herpich C, Norman K. Anti-inflammatory diets and fatigue. Nutrients. 2019;11(10):2315-38.
19. Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev. 2000;5(2):93-108.
20. Christley Y, Duffy T, Martin CR. Interactions between diet, immune system and brain function in the symptom profile of chronic fatigue syndrome. In: Preedy VR, Watson RR, Martin CR, editors. Handbook of Behavior, Food and Nutrition. New York: Springer; 2011. p. 1845- 57.
21. Castro-Marrero J, Sáez-Francàs N, Santillo D, Alegre J. Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: All roads lead to Rome. Br J Pharmacol. 2017;174(5):345-69.
22. Freidin MB, Wells HRR, Potter T, Livshits G, Menni C, Williams FMK. Metabolomic markers of fatigue: Association between circulating metabolome and fatigue in women with chronic widespread pain. Biochim Biophys Acta (BBA)-Molecular Basis Dis. 2018;1864(2):601-6.
23. Alfano CM, Imayama I, Neuhouser ML, Kiecolt-Glaser JK, Smith AW, Meeske K, et al. Fatigue, inflammation, and ω-3 and ω-6 fatty acid intake among breast cancer survivors. J Clin Oncol. 2012;30(12):1280-7.
24. Sánchez-Lara K, Turcott JG, Juarez-Hernandez E, Nunez- Valencia C, Villanueva G, Guevara P, et al. Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: Randomised trial. Clin Nutr. 2014;33:1017-23.
25. Weinstock-Guttman B, Baier M, Park Y, Feichter J, Lee- Kwen P, Gallagher E, et al. Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients. Prostaglandins Leukot. Essent Fatty Acids. 2005;73:397-404.
26. Castro-Marrero J, Cordero MD, Segundo MJ, Sáez- Francas N, Calvo N, Román-Malo L, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015;22(8):679-85.
27. Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, et al. Can coenzyme Q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal. 2013;19(12):1356- 61.
28. Pan W-H, Chang Y-P, Yeh W-T, Guei Y-S, Lin B-F, Wei I-L, vd. Co-occurrence of anemia, marginal vitamin B6, and folate status and depressive symptoms in older adults. J Geriatr Psychiatry Neurol. 2012;25(3):170-8.
29. Lapp CW, Cheney PR. The rationale for using high-dose cobalamin (vitamin B12). CFIDS Chronicle Physicians’ Forum. 1993(Fall);19-20.
30. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, Zachrisson O, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10(4):e0124648.
31. Witham M, Kennedy G, Belch J, Hill A, Khan F. Association between vitamin D status and markers of vascular health in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Int J Cardiol. 2014;174(1):139-40.
32. Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, Belch JJF, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome-a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25(3):287-94.
33. Bitarafan S, Saboor-Yaraghi A, Sahraian M-A, Soltani D, Nafissi S, Togha M, et al. Effect of vitamin A supplementation on fatigue and depression in multiple sclerosis patients: A double-blind placebo- controlled clinical trial. Iran J Allergy, Asthma Immunol. 2016;15(1):13-9.
34. Vollbracht C, Kraft K. Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue. Nutrients. 2021;13(4):1154.
35. Kim S-H, Kim H-J, Kim S, Kang J-S, Koo YT, Lee SH, et al. A comparative study of antifatigue effects of taurine and vitamin C on chronic fatigue syndrome. Pharmacol Pharm. 2022;13(8):300-12.
36. Miwa K, Fujita M. Increased oxidative stress suggested by low serum vitamin E concentrations in patients with chronic fatigue syndrome. Int J Cardiol. 2009;136(2):238- 9.
37. Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in chronic fatigue syndrome (CFS): Relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90(2-3):141-7.
38. Bitarafan S, Harirchian M-H, Nafissi S, Sahraian M-A, Togha M, Siassi F, vd. Dietary intake of nutrients and its correlation with fatigue in multiple sclerosis patients. Iran J Neurol. 2014;13(1):28.
39. Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Neve J, De Leeuw I. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: Effects of supplementation with magnesium. J Am Coll Nutr. 2000;19(3):374-82.
40. Ribeiro SMDF, Braga CBM, Peria FM, Martinez EZ, Rocha JJRD, Cunha SFC. Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer. Einstein (Sao Paulo). 2017;15(1):24-8.

APA	Onur A (2022). Kronik Yorgunluk Sendromu Beslenme İlişkisi. , 103 - 111. 10.33076/2022.BDD.1680
Chicago	Onur Aslı Kronik Yorgunluk Sendromu Beslenme İlişkisi. (2022): 103 - 111. 10.33076/2022.BDD.1680
MLA	Onur Aslı Kronik Yorgunluk Sendromu Beslenme İlişkisi. , 2022, ss.103 - 111. 10.33076/2022.BDD.1680
AMA	Onur A Kronik Yorgunluk Sendromu Beslenme İlişkisi. . 2022; 103 - 111. 10.33076/2022.BDD.1680
Vancouver	Onur A Kronik Yorgunluk Sendromu Beslenme İlişkisi. . 2022; 103 - 111. 10.33076/2022.BDD.1680
IEEE	Onur A "Kronik Yorgunluk Sendromu Beslenme İlişkisi." , ss.103 - 111, 2022. 10.33076/2022.BDD.1680
ISNAD	Onur, Aslı. "Kronik Yorgunluk Sendromu Beslenme İlişkisi". (2022), 103-111. https://doi.org/10.33076/2022.BDD.1680

APA	Onur A (2022). Kronik Yorgunluk Sendromu Beslenme İlişkisi. Beslenme ve Diyet Dergisi, 50(3), 103 - 111. 10.33076/2022.BDD.1680
Chicago	Onur Aslı Kronik Yorgunluk Sendromu Beslenme İlişkisi. Beslenme ve Diyet Dergisi 50, no.3 (2022): 103 - 111. 10.33076/2022.BDD.1680
MLA	Onur Aslı Kronik Yorgunluk Sendromu Beslenme İlişkisi. Beslenme ve Diyet Dergisi, vol.50, no.3, 2022, ss.103 - 111. 10.33076/2022.BDD.1680
AMA	Onur A Kronik Yorgunluk Sendromu Beslenme İlişkisi. Beslenme ve Diyet Dergisi. 2022; 50(3): 103 - 111. 10.33076/2022.BDD.1680
Vancouver	Onur A Kronik Yorgunluk Sendromu Beslenme İlişkisi. Beslenme ve Diyet Dergisi. 2022; 50(3): 103 - 111. 10.33076/2022.BDD.1680
IEEE	Onur A "Kronik Yorgunluk Sendromu Beslenme İlişkisi." Beslenme ve Diyet Dergisi, 50, ss.103 - 111, 2022. 10.33076/2022.BDD.1680
ISNAD	Onur, Aslı. "Kronik Yorgunluk Sendromu Beslenme İlişkisi". Beslenme ve Diyet Dergisi 50/3 (2022), 103-111. https://doi.org/10.33076/2022.BDD.1680