TY  - JOUR
TI  - Investigation of the neuroprotective effect of kefir in experimental spinal cord injury
AB  - In this study, the antioxidant, anti-inflammatory, and neuroprotective effects of kefir were investigated in spinal cord injury that was experimentally created on rats with a compression trauma model. A total of 56 Wistar-Albino male rats were used in the study. Daily freshly prepared 18 ml/kg/day of kefir was given by oral gavage to animals 7 days before and during the trauma and during the trauma. Spinal cord injury was created according to the weight drop method. On the 1st and 7th days before euthanasia, intracardiac blood was collected for analysis, and then they were sacrificed. The damaged spinal cord segments were examined biochemically, immunohistochemically, and histopathologically. When compared to the sham groups, kefir had a positive effect in the preconditioning and treatment groups by decreasing spinal cord bleeding, edema, myelin sheath damage, liquefactive necrosis, neuronal necrosis, selectivity of canalis centralis, and gitter cell levels significantly. When compared to the sham groups, kefir was found to have a positive effect in the treatment groups by decreasing the neuron specific enolase (NSE), ionized calcium binding adapter molecule 1 (IBA-1), inducible nitric oxide synthase (INOS), cyclooxygenase 2 (COX-2) and myelin basic protein (MBP) levels significantly on the 1st and 7th days, and by increasing the glial fibrillary acidic protein (GFAP) level significantly. As a result, it was demonstrated that kefir had a protective and therapeutic effect on spinal cord injury.
AU  - Özsoy, Bülent
AU  - ALAKUŞ, Halil
AU  - ALTUĞ, Muhammed Enes
AU  - YURTAL, ZİYA
AU  - Kutlu, Tuncer
AU  - OZSOY, SULE YURDAGÜL
DO  - 10.33988/auvfd.872947
PY  - 2023
JO  - Ankara Üniversitesi Veteriner Fakültesi Dergisi
VL  - 70
IS  - 1
SN  - 1300-0861
SP  - 9
EP  - 19
DB  - TRDizin
UR  - http://search/yayin/detay/1152563
ER  -