Objectives Neutrophil to lymphocyte ratio; as an inexpensive, easily measurable, and repeatable laboratory parameter is an indicator of subclinical inflammation, and is also a parameter that gives an idea about the systemic inflammatory response and cellular immune response. In general, lymphopenia reflects the weakness of cellular immunity, while neutrophilia is indicative of the response to systemic inflammation. The ratio of these two values to each other seems to be a marker showing the adequacy of the cellular immune response against this situation, despite the magnitude of systemic inflammation. In this study, we aimed to investigate the relationship between preoperative neutrophil-lymphocyte ratio (NLR) and postoperative analgesic drug consumption. Materials and Method Within the scope of the study, the files of 50 patients who underwent bimaxillary orthognathic surgery were retrospectively analyzed. The preoperative NLR values of the patients and the need for the analgesic drugs in the first 24 hours and after 24 hours were recorded and correlated. Results 24% of the patients were girls and 76% were boys. The average age was 20.54, and the average weight was 65.28 kg. There was a positive, strong, and significant correlation between the preoperative neutrophil count and preoperative NLR value and variables of analgesic drug consumption in the first 24 hours (r = 0.6814, p <0.001, and r = 0.6148, p <0.001, respectively). There was a negative, strong and significant correlation between the preoperative lymphocyte count and the first 24-hour analgesic drug consumption variables (r = -0.6773, p <0.001). Conclusion It was concluded that patients with a preoperative NLR value of 2.11 and above may require 4 or more analgesics in the first 24 hours, therefore, NLR value can give preliminary information about the need for postoperative analgesia, and these values could be taken into account when developing a strategy for postoperative analgesia.