Purpose: This study was carried out in order to identify the safety measures of mothers for home accidents and to determine their first aid self- efficacy status during the period when children are prohibited from leaving the home due to the COVID-19 pandemic and they have to stay at home. Methods: The study is cross-sectional and descriptive. The study was completed with 535 mothers. An introductory information form, the Scale for Diagnosing Safety Measures for Home Accidents, and the First Aid Self-Efficacy Scale for Home Accidents were used to collect data. Results: In the study, 73.8% of the mothers stated that they took precautions for home accidents, and 13.6% stated that their children had a home accident during the pandemic period. In the study, it was determined that mothers' levels of identifying safety measures (165.1±13.3) and first aid self- efficacy (43.2±10.1) were high. It was determined that the level of identification of safety measures of mothers with a small number of children, and the first aid self-efficacy levels of mothers with stairs in their homes were higher. It was determined that as age, income level and education level increased, the precautions taken by mothers for home accidents increased (p<0.05). Conclusions: In the study, it was determined that children had home accidents during the pandemic period. It was found that the majority of the mothers took precautions against home accidents, and the mothers had high self-efficacy levels in diagnosing safety precautions and first aid. In the study, it was determined that the education of mothers about first aid increased their first aid self- efficacy and identification of safety measures for home accidents.