Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study
Yıl: 2021 Cilt: 18 Sayı: 2 Sayfa Aralığı: 762 - 769 Metin Dili: İngilizce DOI: 10.38136/jgon.782847 İndeks Tarihi: 25-01-2023
Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study
Öz: Aim: To measure maternal blood elements namely, aluminium (Al), antimony (Sb), arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), man- ganese (Mn), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), tin (Sn), and zinc (Zn) in pregnant women complicated by preterm prelabor rupture of the membranes (pP-ROM) and to compare the results with healthy controls. Materials and Methods: Maternal blood levels of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn were evaluated in the pP-ROM group, which included 55 pregnant women complicated by pP-ROM and 60 healthy participants (control group) with respect to gestational weeks and maternal age. The maternal serum levels of trace elements and heavy metals in both groups were measured using inductively coupled plasma-mass spectrometry (ICP-MS) and compared. Results: 1o significant differences regarding gestational week, body mass index, gravidity, parity, and maternal age were observed p The mean serum whi- te blood cell level was higher in the pP-ROM group compared with the healthy controls (12.2±3.5 μL/mL vs. 10.1±2.6 μL/mL, respectively; p=0.001). The mean serum C-reactive protein level was higher in the pP-ROM group than in the he- althy group (0.99±1.47 mg/L vs. 0.40±0.27 mg/L, respectively; p=0.003). There were no differences in terms of mean maternal serum levels of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn between the study and control group p Conclusion: The selected trace elements and heavy metals in maternal serum are not involved in the pathogenesis of pP-ROM.
Anahtar Kelime: Preterm erken membran rüptürü ile komplike olan gebeliklerde seçilen eser elementler ve ağır metallerin maternal serumdaki seviyeleri: Prospektif vaka-kontrollü çalışma
Öz: Amaç: Alüminyum(Al), krom(Cr), manganez(Mn), kobalt(Co), nikel(Ni), bakır(Cu), çinko(Zn), arsenik(As), molibden(Mo), kadmiyum(Cd), kalay(Sn), antimon(Sb), civa(Hg) ve kurşun(Pb) isimli eser element ve ağır metallerin maternal serum seviyelerini, preterm erken membran rüptürü (pP-ROM) ile komplike olmuş gebelerde ve sağlıklı gebelerde karşılaştırmaktır. Gereçler ve Yöntem: pP-ROM ile komplike 55 gebeden oluşan çalışma grubu ile, anne yaşı ve gebelik haftası açısından benzer olan 60 sağlıklı gebenin (kontrol grubu) Al, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sn, Sb, Hg ve Pb serum düzeyleri ölçüldü. Her iki gruptaki eser elementlerin ve ağır metallerin maternal serum seviyeleri, indüktif olarak eşleşmiş plazma kütle spektrometrisi kullanılarak ölçülmüş ve karşılaştırılmıştır. Bulgular: Anne yaşı, vücut kitle indeksi, gebelik sayısı, doğum sayısı ve gebelik haftaları ortalamaları incelendiğinde, iki grupta anlamlı bir fark görülmedi (p≥0.05). Ortalama serum beyaz kan hücresi seviyesi, pP-ROM grubunda sağlıklı kontrollerden daha yüksekti (sırasıyla, 12.2 ± 3.5 LL / mL vs 10.1 ± 2.6 LL / mL; p: 0.001). Ortalama serum C-reaktif protein düzeyi, pP-ROM grubunda sağlıklı kontrollerden daha yüksekti (sırasıyla, 0.99 ± 1.47 mg / L'ye karşılık 0.40 ± 0.27 mg / L; p: 0.003). Ayrıca, ortalama doğum ağırlığı, pP-ROM grubunda sağlıklı kontrollere göre anlamlı derecede düşüktü (sırasıyla 1859 ± 567 gram, 3209 ± 471 gram; p: 0.001). Gruplar arasında Al, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sn, Sb, Hg ve Pb ortalama maternal serum düzeyleri açısından anlamlı fark bulunmadı (p≥0.05). Sonuç: Maternal serumda ölçülen bu seçilmiş eser elementler ve ağır metaller, pP-ROM'un patogenezinde önemli gözükmemektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ovayolu A, BOSTANCIERI N, GÜLER S, Dogan I, TURKSOY V, Kolusarı A (2021). Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. , 762 - 769. 10.38136/jgon.782847 |
| Chicago | Ovayolu Ali,BOSTANCIERI NURAY,GÜLER Selver,Dogan Ilkay,TURKSOY Vugar Ali,Kolusarı Ali Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. (2021): 762 - 769. 10.38136/jgon.782847 |
| MLA | Ovayolu Ali,BOSTANCIERI NURAY,GÜLER Selver,Dogan Ilkay,TURKSOY Vugar Ali,Kolusarı Ali Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. , 2021, ss.762 - 769. 10.38136/jgon.782847 |
| AMA | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. . 2021; 762 - 769. 10.38136/jgon.782847 |
| Vancouver | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. . 2021; 762 - 769. 10.38136/jgon.782847 |
| IEEE | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A "Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study." , ss.762 - 769, 2021. 10.38136/jgon.782847 |
| ISNAD | Ovayolu, Ali vd. "Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study". (2021), 762-769. https://doi.org/10.38136/jgon.782847 |
| APA | Ovayolu A, BOSTANCIERI N, GÜLER S, Dogan I, TURKSOY V, Kolusarı A (2021). Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18(2), 762 - 769. 10.38136/jgon.782847 |
| Chicago | Ovayolu Ali,BOSTANCIERI NURAY,GÜLER Selver,Dogan Ilkay,TURKSOY Vugar Ali,Kolusarı Ali Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 18, no.2 (2021): 762 - 769. 10.38136/jgon.782847 |
| MLA | Ovayolu Ali,BOSTANCIERI NURAY,GÜLER Selver,Dogan Ilkay,TURKSOY Vugar Ali,Kolusarı Ali Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, vol.18, no.2, 2021, ss.762 - 769. 10.38136/jgon.782847 |
| AMA | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2021; 18(2): 762 - 769. 10.38136/jgon.782847 |
| Vancouver | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2021; 18(2): 762 - 769. 10.38136/jgon.782847 |
| IEEE | Ovayolu A,BOSTANCIERI N,GÜLER S,Dogan I,TURKSOY V,Kolusarı A "Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study." Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18, ss.762 - 769, 2021. 10.38136/jgon.782847 |
| ISNAD | Ovayolu, Ali vd. "Maternal serum levels of selected trace elements and heavy metals in pregnancies complicated by preterm prelabor rupture of membranes: A prospective and case-controlled study". Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 18/2 (2021), 762-769. https://doi.org/10.38136/jgon.782847 |
