TY  - JOUR
TI  - Effects of Chronic Oral Monosodium Glutamate Consumption on Naloxane-Induced Morphine Withdrawal in Infant Rats
AB  - Aim: The aim of this study was to investigate chronic oral monosodium glutamate (MSG) consumption effects on symptoms of withdrawal, locomotor activity, and anxiety in morphine withdrawal syndrome induced by naloxone in infant rats. Materials and Methods: Twelve 21-day-old male Wistar rats used in the study. Infant rats were given unlimited access to saline (control group) or MSG (MSG group) added to drinking water for 32 days. Withdrawal was induced by naloxone in morphine-dependent rats. Evaluation of withdrawal symptoms and anxiety were performed simultaneously with locomotor activity measurements. Results: Withdrawal sings, such as jumping, wet dog shake, and weight loss; stereotypic, ambulatory, and vertical locomotor activity movements; central, peripheral, and total activities used in the assessment of anxiety in infant rats with naloxone-induced withdrawal syndrome that consumed oral MSG for 32 days were not different from the control group. Conclusion: These findings obtained in our study indicate that chronic consumption of oral MSG in infant rats whose blood-brain barrier has not yet developed does not affect morphine dependence and naloxone-induced withdrawal. Further studies are needed to investigate the mechanism of action of orally administered MSG.
AU  - JAFAROVA DEMIRKAPU, MAHLUGA
AU  - Kılınç, Melih
AU  - özkula, songül
AU  - YANANLI, Hasan Raci
AU  - YILDIZ, Merve
AU  - Temel, Hasan
AU  - Özen, Berna
AU  - Kutluay, Sena Nur
AU  - Büyük, Mustafa
DO  - 10.29058/mjwbs.1124034
PY  - 2022
JO  - Batı Karadeniz Tıp Dergisi
VL  - 6
IS  - 3
SN  - 2822-4302
SP  - 378
EP  - 384
DB  - TRDizin
UR  - http://search/yayin/detay/1154093
ER  -