Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy

Yıl: 2021 Cilt: 4 Sayı: 6 Sayfa Aralığı: 853 - 857 Metin Dili: İngilizce DOI: 10.32322/jhsm.984394 İndeks Tarihi: 30-01-2023

Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy

Öz:
Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% of all childhood cancers. It is tried to achieve cure with combined treatment modalities consisting of chemotherapy, radiotherapy, monoclonal antibodies, and new treatment agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, and local skin reactions can be seen in the pediatric age group with a long life expectancy. In this article, pediatric patients diagnosed with Hodgkin lymphoma without the use of radiotherapy in the treatment were evaluated retrospectively and the survival results were reported as a single-center experience. Material and Method: The patients with Hodgkin Lymphoma in the Pediatrics Hematology-Oncology Center at Erciyes University between January 2010 and December 2019 were included in the study and the data of the patients were evaluated retrospectively. Results: In 68 pediatric patients with a mean age of 10.7 (±4.6) years, the male/female ratio was 1.3. The most detected finding at the time of diagnosis was cervical lymphadenopathy (83.8%). The most common mixed cellular subtype was identified (48.5%). Stage I-II disease was observed in 38.3% of the patients, and stage III-IV disease was observed in 61.7% of the patients. The median follow-up period of the patients was 61 (range, 8.3-161.6) months. Disease-free survival and overall survival were 85.3% and 94.1%, respectively. Treatment modalities to be used in this disease group, which has a high chance of cure after cytotoxic treatment, should be selected considering treatment-related long-term complications. Conclusion: Acceptable good results obtained without radiotherapy are satisfactory and the chance of curative success will increase with the addition of new target agents to the treatment.
Anahtar Kelime: Hodgkin lymphoma children radiotherapy

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA YILMAZ E, Arslan M, Akyol Ş, Ozcan A, Zararsiz G, Abdulrezzak U, KONTAŞ O, canöz ö, UNAL E, Karakukcu M (2021). Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. , 853 - 857. 10.32322/jhsm.984394
Chicago YILMAZ Ebru,Arslan Memnune,Akyol Şefika,Ozcan Alper,Zararsiz Gokmen,Abdulrezzak Ummuhan,KONTAŞ OLGUN,canöz özlem,UNAL Ekrem,Karakukcu Musa Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. (2021): 853 - 857. 10.32322/jhsm.984394
MLA YILMAZ Ebru,Arslan Memnune,Akyol Şefika,Ozcan Alper,Zararsiz Gokmen,Abdulrezzak Ummuhan,KONTAŞ OLGUN,canöz özlem,UNAL Ekrem,Karakukcu Musa Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. , 2021, ss.853 - 857. 10.32322/jhsm.984394
AMA YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. . 2021; 853 - 857. 10.32322/jhsm.984394
Vancouver YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. . 2021; 853 - 857. 10.32322/jhsm.984394
IEEE YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M "Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy." , ss.853 - 857, 2021. 10.32322/jhsm.984394
ISNAD YILMAZ, Ebru vd. "Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy". (2021), 853-857. https://doi.org/10.32322/jhsm.984394
APA YILMAZ E, Arslan M, Akyol Ş, Ozcan A, Zararsiz G, Abdulrezzak U, KONTAŞ O, canöz ö, UNAL E, Karakukcu M (2021). Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. Journal of health sciences and medicine (Online), 4(6), 853 - 857. 10.32322/jhsm.984394
Chicago YILMAZ Ebru,Arslan Memnune,Akyol Şefika,Ozcan Alper,Zararsiz Gokmen,Abdulrezzak Ummuhan,KONTAŞ OLGUN,canöz özlem,UNAL Ekrem,Karakukcu Musa Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. Journal of health sciences and medicine (Online) 4, no.6 (2021): 853 - 857. 10.32322/jhsm.984394
MLA YILMAZ Ebru,Arslan Memnune,Akyol Şefika,Ozcan Alper,Zararsiz Gokmen,Abdulrezzak Ummuhan,KONTAŞ OLGUN,canöz özlem,UNAL Ekrem,Karakukcu Musa Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. Journal of health sciences and medicine (Online), vol.4, no.6, 2021, ss.853 - 857. 10.32322/jhsm.984394
AMA YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. Journal of health sciences and medicine (Online). 2021; 4(6): 853 - 857. 10.32322/jhsm.984394
Vancouver YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy. Journal of health sciences and medicine (Online). 2021; 4(6): 853 - 857. 10.32322/jhsm.984394
IEEE YILMAZ E,Arslan M,Akyol Ş,Ozcan A,Zararsiz G,Abdulrezzak U,KONTAŞ O,canöz ö,UNAL E,Karakukcu M "Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy." Journal of health sciences and medicine (Online), 4, ss.853 - 857, 2021. 10.32322/jhsm.984394
ISNAD YILMAZ, Ebru vd. "Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy". Journal of health sciences and medicine (Online) 4/6 (2021), 853-857. https://doi.org/10.32322/jhsm.984394