TY  - JOUR
TI  - Single-center experience of childhood Hodgkin lymphoma treated without radiotherapy
AB  - Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% of all childhood cancers. It is tried to achieve cure with combined treatment modalities consisting of chemotherapy, radiotherapy, monoclonal antibodies, and new treatment agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, and local skin reactions can be seen in the pediatric age group with a long life expectancy. In this article, pediatric patients diagnosed with Hodgkin lymphoma without the use of radiotherapy in the treatment were evaluated retrospectively and the survival results were reported as a single-center experience. Material and Method: The patients with Hodgkin Lymphoma in the Pediatrics Hematology-Oncology Center at Erciyes University between January 2010 and December 2019 were included in the study and the data of the patients were evaluated retrospectively. Results: In 68 pediatric patients with a mean age of 10.7 (±4.6) years, the male/female ratio was 1.3. The most detected finding at the time of diagnosis was cervical lymphadenopathy (83.8%). The most common mixed cellular subtype was identified (48.5%). Stage I-II disease was observed in 38.3% of the patients, and stage III-IV disease was observed in 61.7% of the patients. The median follow-up period of the patients was 61 (range, 8.3-161.6) months. Disease-free survival and overall survival were 85.3% and 94.1%, respectively. Treatment modalities to be used in this disease group, which has a high chance of cure after cytotoxic treatment, should be selected considering treatment-related long-term complications. Conclusion: Acceptable good results obtained without radiotherapy are satisfactory and the chance of curative success will increase with the addition of new target agents to the treatment.
AU  - Zararsiz, Gokmen
AU  - Arslan, Memnune
AU  - YILMAZ, Ebru
AU  - UNAL, Ekrem
AU  - Karakukcu, Musa
AU  - canöz, özlem
AU  - Abdulrezzak, Ummuhan
AU  - Akyol, Şefika
AU  - KONTAŞ, OLGUN
AU  - Ozcan, Alper
DO  - 10.32322/jhsm.984394
PY  - 2021
JO  - Journal of  health sciences and medicine (Online)
VL  - 4
IS  - 6
SN  - 2636-8579
SP  - 853
EP  - 857
DB  - TRDizin
UR  - http://search/yayin/detay/1154923
ER  -