Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions
Yıl: 2023 Cilt: 10 Sayı: 1 Sayfa Aralığı: 185 - 192 Metin Dili: İngilizce DOI: 10.18596/jotcsa.1142274 İndeks Tarihi: 06-03-2023
Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions
Öz: Every year, millions of tons of food and beverage waste are thrown away unused around the world. The carbohydrates found in food waste create a raw material potential for the production of high value-added products that are used in energy, feed and pharmacology. One of these products, 5-Hydroxymethyl-2-furfural (5-HMF), is a by-product of simple dehydration of carbohydrates. It finds wide use in the field of pharmacy due to its anticancer, antifungal and antimicrobial activities. Many studies have stated that the sugar source with the highest conversion rate in 5-HMF production is fructose. For this reason, in this study, it was aimed to realize the production of 5-HMF in autoclave sterilization carried out under high temperature and pressure using grape must waste, which is known to have high fructose content, and determine the anticarcinogenic activity and cytotoxicity of the produced 5-HMF under in vitro conditions. In this study, it was determined that the medium containing DMSO increased the sugar conversion percentage, 5-HMF efficiency and selectivity in the waste grape must more than the medium containing only water. In the production of 5-HMF, the conversion of sugar in the medium saturated with salt, and the efficiency and selectivity of 5-HMF were determined as 97.04%, 68.61% and 70.82%, respectively, when DMSO organic solvent was used. In addition, it has been determined that 5-HMF produced from waste grape must has a toxic effect on both healthy cells and cancer cells and has anticancer properties.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kelleci k, golebatmaz e (2023). Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. , 185 - 192. 10.18596/jotcsa.1142274 |
| Chicago | Kelleci kübra,golebatmaz eda Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. (2023): 185 - 192. 10.18596/jotcsa.1142274 |
| MLA | Kelleci kübra,golebatmaz eda Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. , 2023, ss.185 - 192. 10.18596/jotcsa.1142274 |
| AMA | Kelleci k,golebatmaz e Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. . 2023; 185 - 192. 10.18596/jotcsa.1142274 |
| Vancouver | Kelleci k,golebatmaz e Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. . 2023; 185 - 192. 10.18596/jotcsa.1142274 |
| IEEE | Kelleci k,golebatmaz e "Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions." , ss.185 - 192, 2023. 10.18596/jotcsa.1142274 |
| ISNAD | Kelleci, kübra - golebatmaz, eda. "Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions". (2023), 185-192. https://doi.org/10.18596/jotcsa.1142274 |
| APA | Kelleci k, golebatmaz e (2023). Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. Journal of the Turkish Chemical Society, Section A: Chemistry, 10(1), 185 - 192. 10.18596/jotcsa.1142274 |
| Chicago | Kelleci kübra,golebatmaz eda Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. Journal of the Turkish Chemical Society, Section A: Chemistry 10, no.1 (2023): 185 - 192. 10.18596/jotcsa.1142274 |
| MLA | Kelleci kübra,golebatmaz eda Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. Journal of the Turkish Chemical Society, Section A: Chemistry, vol.10, no.1, 2023, ss.185 - 192. 10.18596/jotcsa.1142274 |
| AMA | Kelleci k,golebatmaz e Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. Journal of the Turkish Chemical Society, Section A: Chemistry. 2023; 10(1): 185 - 192. 10.18596/jotcsa.1142274 |
| Vancouver | Kelleci k,golebatmaz e Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions. Journal of the Turkish Chemical Society, Section A: Chemistry. 2023; 10(1): 185 - 192. 10.18596/jotcsa.1142274 |
| IEEE | Kelleci k,golebatmaz e "Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions." Journal of the Turkish Chemical Society, Section A: Chemistry, 10, ss.185 - 192, 2023. 10.18596/jotcsa.1142274 |
| ISNAD | Kelleci, kübra - golebatmaz, eda. "Determination of the Anticarcinogenic Activity of 5-Hydroxymethyl-2-furfural Produced from Grape Must Under in vitro Conditions". Journal of the Turkish Chemical Society, Section A: Chemistry 10/1 (2023), 185-192. https://doi.org/10.18596/jotcsa.1142274 |
