TY  - JOUR
TI  - Electrochemical determination of aripiprazole based on aluminium oxide nanoparticles modified carbon paste electrode
AB  - The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. Under optimum conditions, the peak current exhibited a linear dependence with aripiprazole concentration between 0.03 and 8.0 μM with a detection limit of 0.006 μM. The analytical applicability of the voltammetric method was evaluated by quantification of ARP in human serum samples and pharmaceutical formulations.
AU  - kılıç, esma
AU  - Öztürk, Funda
AU  - YÜKSEL, ELİF
AU  - Erden, Pınar Esra
DO  - 10.55730/1300-0527.3523
PY  - 2023
JO  - Turkish Journal of Chemistry
VL  - 47
IS  - 1
SN  - 1300-0527
SP  - 126
EP  - 136
DB  - TRDizin
UR  - http://search/yayin/detay/1158709
ER  -