TY  - JOUR
TI  - Chronic inflammatory demyelinating neuropathy after etanercept therapy in the course of juvenile idiopathic arthritis
AB  - Background. Chronic inflammatory demyelinating neuropathy has been reported after the use of tumor necrosis factor inhibitors. The mechanisms of nerve injury caused by tumor necrosis factor inhibitors are not yet well understood. Case. In this paper, we report a 12 year and nine month old girl who developed chronic inflammatory demyelinating neuropathy in the course of juvenile idiopathic arthritis after etanercept withdrawal. She became non-ambulant with four-limb involvement. She received intravenous immunoglobulins, steroids, and plasma exchange, but had a limited response. Finally, rituximab was given and a slow, but progressive clinical improvement was seen. She was ambulant four months after rituximab treatment. We considered chronic inflammatory demyelinating neuropathy as a probable adverse effect of etanercept. Conclusions. Tumor necrosis factor inhibitors could elicit the demyelinating process, and chronic inflammatory demyelinating neuropathy might persist despite treatment discontinuation. First-line immunotherapy may be inefficient as in our case, and aggressive treatment may be necessary.
AU  - Kutlubay, Büşra
AU  - sozen, hatice gulhan
AU  - sozeri, betul
AU  - SURMELI, Reyhan
AU  - Maraş Genç, Hülya
DO  - 10.24953/turkjped.2021.4573
PY  - 2023
JO  - Turkish Journal of Pediatrics
VL  - 65
IS  - 1
SN  - 0041-4301
SP  - 165
EP  - 169
DB  - TRDizin
UR  - http://search/yayin/detay/1159033
ER  -