TY  - JOUR
TI  - Evaluation of Phytochemical Contents and Biological Activities of Salvia officinalis and Salvia triloba Grown with Organic Farming
AB  - Salvia officinalis L., known as medicinal sage, and Salvia triloba L., known as Anatolian sage, belong to the Lamiaceae family and are species that usually grow in the Mediterranean region. In this study, it was aimed to evaluate the in vitro antidiabetic, antiobesity and antioxidant potentials of the extracts prepared by infusion technique from S. officinalis and S. triloba has grown by organic farming methods. In addition, the effects of the extracts on the pancreatic cholesterol esterase enzyme were also investigated.The Reverse Phase- High Performance Liquid Chromatography (HPLC) technique was used to analyze the phytochemical contents of the extracts. At a concentration of 2 mg/mL, S. officinalis inhibited 64.69% ± 0.23, S. triloba 47.78 ± 2.11% on the α-glucosidase enzyme. Only S. triloba had an inhibitory effect on α-amylase and pancreatic lipase enzyme. On the pancreatic cholesterol esterase enzyme, inhibition values of S. triloba extract at all tested concentrations was found higher than S. officinalis extract. It was observed that the S. officinalis extract had the highest reducing power potential. The metal chelating capacity of both extracts at a concentration of 2 mg/mL was calculated as 100%. It was concluded that the ABTS radical scavenging activity of the extracts increased in a dose-dependently manner. The amounts of rosmarinic acid and hesperidin were found higher in S. officinalis extract than in S. triloba extract by Reverse Phase-HPLC technique. The presence of hesperidin in S. triloba was detected for the first time in this study. These findings considering it was concluded that activity- guided isolation and in vivo activity studies should be performed because these two species grown the organic farming methods have potent α-glucosidase enzyme inhibitory and antioxidant effects.
AU  - Pekacar, Sultan
AU  - Deliorman Orhan, Didem
AU  - ÖZÜPEK, BURÇİN
DO  - 10.55262/fabadeczacilik.1175781
PY  - 2023
JO  - FABAD Journal of Pharmaceutical Sciences
VL  - 48
IS  - 1
SN  - 1300-4182
SP  - 125
EP  - 138
DB  - TRDizin
UR  - http://search/yayin/detay/1159132
ER  -