RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans
Yıl: 2023 Cilt: 47 Sayı: 1 Sayfa Aralığı: 74 - 83 Metin Dili: İngilizce DOI: 10.55730/1300-0152.2642 İndeks Tarihi: 22-03-2023
RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans
Öz: Projecting from most cell surfaces, cilia serve as important hubs for sensory and signaling processes and have been linked to a variety of human disorders, including Bardet-Biedl Syndrome (BBS), Meckel-Gruber Syndrome (MKS), Nephronophthisis (NPHP), and Joubert Syndrome, and these diseases are collectively known as a ciliopathy. DCDC2 is a ciliopathy protein that localizes to cilia; nevertheless, our understanding of the role of DCDC2 in cilia is still limited. We employed C. elegans to investigate the function of C. elegans RPI-1, a Caenorhabditis elegans ortholog of human DCDC2, in cilia and found that C. elegans RPI-1 localizes to the entire ciliary axoneme, but is not present in the transition zone and basal body. We generated a null mutant of C. elegans rpi-1, and our analysis with a range of fluorescence-based ciliary markers revealed that DCDC2 and nephronophthisis 4 (NPHP-4/NPHP4) display functional redundant roles in regulating cilia length and cilia positions. Taken together, our analysis discovered a novel genetic interaction between two ciliopathy disease genes (RPI-1/DCDC2 and NPHP-4/NPHP4) in C. elegans.
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| APA | Kaplan O (2023). RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. , 74 - 83. 10.55730/1300-0152.2642 |
| Chicago | Kaplan Oktay Ismail RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. (2023): 74 - 83. 10.55730/1300-0152.2642 |
| MLA | Kaplan Oktay Ismail RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. , 2023, ss.74 - 83. 10.55730/1300-0152.2642 |
| AMA | Kaplan O RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. . 2023; 74 - 83. 10.55730/1300-0152.2642 |
| Vancouver | Kaplan O RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. . 2023; 74 - 83. 10.55730/1300-0152.2642 |
| IEEE | Kaplan O "RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans." , ss.74 - 83, 2023. 10.55730/1300-0152.2642 |
| ISNAD | Kaplan, Oktay Ismail. "RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans". (2023), 74-83. https://doi.org/10.55730/1300-0152.2642 |
| APA | Kaplan O (2023). RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. Turkish Journal of Biology, 47(1), 74 - 83. 10.55730/1300-0152.2642 |
| Chicago | Kaplan Oktay Ismail RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. Turkish Journal of Biology 47, no.1 (2023): 74 - 83. 10.55730/1300-0152.2642 |
| MLA | Kaplan Oktay Ismail RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. Turkish Journal of Biology, vol.47, no.1, 2023, ss.74 - 83. 10.55730/1300-0152.2642 |
| AMA | Kaplan O RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. Turkish Journal of Biology. 2023; 47(1): 74 - 83. 10.55730/1300-0152.2642 |
| Vancouver | Kaplan O RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans. Turkish Journal of Biology. 2023; 47(1): 74 - 83. 10.55730/1300-0152.2642 |
| IEEE | Kaplan O "RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans." Turkish Journal of Biology, 47, ss.74 - 83, 2023. 10.55730/1300-0152.2642 |
| ISNAD | Kaplan, Oktay Ismail. "RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans". Turkish Journal of Biology 47/1 (2023), 74-83. https://doi.org/10.55730/1300-0152.2642 |
