Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures

Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 29 - 39 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5555 İndeks Tarihi: 23-03-2023

Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures

Öz:
Background/aim: We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods: In this experimental animal study, twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results: As an indicator of the antiosteoporotic effect, the calcium levels of the taurine group were significantly lower than the AGE and control groups in biochemical analyzes (p < 0.01). In histological studies, the new bone diameter and new bone volume values of the taurine group were significantly higher than the control group (p = 0.002 and p = 0.032, respectively), while higher trabecular-compact callus was observed in the taurine and AGE groups, respectively, compared to the control group. In morphological analyses, taurine and AGE groups had significantly higher bone volume/tissue volume, trabecular number, bone surface density, and lower trabecular separation than the control group (p < 0.05). The scintigraphic imaging showed a significant increase in osteoblastic activity of the taurine group compared to the control group (p = 0.005). Conclusion: Taurine and AGE have positive anabolic effects, respectively, on the healing of OPFs, demonstrated by biochemical, histological, morphological, and scintigraphic methods.
Anahtar Kelime: Taurine aqueous garlic extract osteoporosis ovariectomized rat femur fracture

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA MISIRLIOĞLU M, bingol i, GENC C, AKBULUT A, ocak m, Diker N, OZMERİC A, Koca G, Kaya Bahçecitapar M, Şeneş M, Firat A, KAYMAZ F, Çelik H, TATLI ÇANKAYA İ, KORKMAZ M (2023). Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. , 29 - 39. 10.55730/1300-0144.5555
Chicago MISIRLIOĞLU MESUT,bingol izzet,GENC COSKUN,AKBULUT Aylin,ocak mert,Diker Neziha Yağmur,OZMERİC AHMET,Koca Gökhan,Kaya Bahçecitapar Melike,Şeneş Mehmet,Firat Aysegul,KAYMAZ FEVZIYE FIGEN,Çelik Hakan Hamdi,TATLI ÇANKAYA İFFET İREM,KORKMAZ MELIHA Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. (2023): 29 - 39. 10.55730/1300-0144.5555
MLA MISIRLIOĞLU MESUT,bingol izzet,GENC COSKUN,AKBULUT Aylin,ocak mert,Diker Neziha Yağmur,OZMERİC AHMET,Koca Gökhan,Kaya Bahçecitapar Melike,Şeneş Mehmet,Firat Aysegul,KAYMAZ FEVZIYE FIGEN,Çelik Hakan Hamdi,TATLI ÇANKAYA İFFET İREM,KORKMAZ MELIHA Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. , 2023, ss.29 - 39. 10.55730/1300-0144.5555
AMA MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. . 2023; 29 - 39. 10.55730/1300-0144.5555
Vancouver MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. . 2023; 29 - 39. 10.55730/1300-0144.5555
IEEE MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M "Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures." , ss.29 - 39, 2023. 10.55730/1300-0144.5555
ISNAD MISIRLIOĞLU, MESUT vd. "Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures". (2023), 29-39. https://doi.org/10.55730/1300-0144.5555
APA MISIRLIOĞLU M, bingol i, GENC C, AKBULUT A, ocak m, Diker N, OZMERİC A, Koca G, Kaya Bahçecitapar M, Şeneş M, Firat A, KAYMAZ F, Çelik H, TATLI ÇANKAYA İ, KORKMAZ M (2023). Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. Turkish Journal of Medical Sciences, 53(1), 29 - 39. 10.55730/1300-0144.5555
Chicago MISIRLIOĞLU MESUT,bingol izzet,GENC COSKUN,AKBULUT Aylin,ocak mert,Diker Neziha Yağmur,OZMERİC AHMET,Koca Gökhan,Kaya Bahçecitapar Melike,Şeneş Mehmet,Firat Aysegul,KAYMAZ FEVZIYE FIGEN,Çelik Hakan Hamdi,TATLI ÇANKAYA İFFET İREM,KORKMAZ MELIHA Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. Turkish Journal of Medical Sciences 53, no.1 (2023): 29 - 39. 10.55730/1300-0144.5555
MLA MISIRLIOĞLU MESUT,bingol izzet,GENC COSKUN,AKBULUT Aylin,ocak mert,Diker Neziha Yağmur,OZMERİC AHMET,Koca Gökhan,Kaya Bahçecitapar Melike,Şeneş Mehmet,Firat Aysegul,KAYMAZ FEVZIYE FIGEN,Çelik Hakan Hamdi,TATLI ÇANKAYA İFFET İREM,KORKMAZ MELIHA Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.29 - 39. 10.55730/1300-0144.5555
AMA MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. Turkish Journal of Medical Sciences. 2023; 53(1): 29 - 39. 10.55730/1300-0144.5555
Vancouver MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures. Turkish Journal of Medical Sciences. 2023; 53(1): 29 - 39. 10.55730/1300-0144.5555
IEEE MISIRLIOĞLU M,bingol i,GENC C,AKBULUT A,ocak m,Diker N,OZMERİC A,Koca G,Kaya Bahçecitapar M,Şeneş M,Firat A,KAYMAZ F,Çelik H,TATLI ÇANKAYA İ,KORKMAZ M "Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures." Turkish Journal of Medical Sciences, 53, ss.29 - 39, 2023. 10.55730/1300-0144.5555
ISNAD MISIRLIOĞLU, MESUT vd. "Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures". Turkish Journal of Medical Sciences 53/1 (2023), 29-39. https://doi.org/10.55730/1300-0144.5555