TY  - JOUR
TI  - Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures
AB  - Background/aim: We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods: In this experimental animal study, twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results: As an indicator of the antiosteoporotic effect, the calcium levels of the taurine group were significantly lower than the AGE and control groups in biochemical analyzes (p < 0.01). In histological studies, the new bone diameter and new bone volume values of the taurine group were significantly higher than the control group (p = 0.002 and p = 0.032, respectively), while higher trabecular-compact callus was observed in the taurine and AGE groups, respectively, compared to the control group. In morphological analyses, taurine and AGE groups had significantly higher bone volume/tissue volume, trabecular number, bone surface density, and lower trabecular separation than the control group (p < 0.05). The scintigraphic imaging showed a significant increase in osteoblastic activity of the taurine group compared to the control group (p = 0.005). Conclusion: Taurine and AGE have positive anabolic effects, respectively, on the healing of OPFs, demonstrated by biochemical, histological, morphological, and scintigraphic methods.
AU  - ocak, mert
AU  - Diker, Neziha Yağmur
AU  - Koca, Gökhan
AU  - KORKMAZ, MELIHA
AU  - AKBULUT, Aylin
AU  - bingol, izzet
AU  - Kaya Bahçecitapar, Melike
AU  - Çelik, Hakan Hamdi
AU  - GENC, COSKUN
AU  - OZMERİC, AHMET
AU  - KAYMAZ, FEVZIYE FIGEN
AU  - TATLI ÇANKAYA, İFFET İREM
AU  - MISIRLIOĞLU, MESUT
AU  - Şeneş, Mehmet
AU  - Firat, Aysegul
DO  - 10.55730/1300-0144.5555
PY  - 2023
JO  - Turkish Journal of Medical Sciences
VL  - 53
IS  - 1
SN  - 1300-0144
SP  - 29
EP  - 39
DB  - TRDizin
UR  - http://search/yayin/detay/1159828
ER  -