Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?

Levent KORKMAZ, (Binali Yıldırım Üniversitesi, Erzincan Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Neonatoloji Anabilim Dalı, Erzincan, Türkiye)
Cumali ALAN, (Erzincan Binali Yıldırım Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Erzincan, Türkiye)
İsmail TOPAL, (Erzincan Binali Yıldırım Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Erzincan, Türkiye)
Mahir TAYFUR, (Erzincan Binali Yıldırım Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Erzincan, Türkiye)
Aliseydi BOZKURT, (Erzincan Binali Yıldırım Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Erzincan, Türkiye)
Cebrail GÜRSUL, (Erzincan Binali Yıldırım Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzincan, Türkiye)
Osman BAŞTUĞ (Kayseri Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Neonatoloji Anabilim Dalı, Kayseri, Türkiye)
Turkish Journal of Medical Sciences
2 0
Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 109 - 120 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5564 İndeks Tarihi: 24-03-2023

Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?

Öz:
Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. Materials and methods: In this experimental study, while the study group was made up of the fetuses of pregnant rats exposed to hyperbaric oxygen, (hyperoxic pregnant rat fetuses-HPRF), the control group was formed of the fetuses of the rats pregnant in the usual room setting (normoxic pregnant rat fetuses-NPRF). The pulmonary and hepatic tissues taken from the fetuses of these pregnant rats on the 21st day of their pregnancy were compared biochemically and histologically. For biochemical assessment, total glutathione (tGSH), catalase (CAT), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α) values and for histopathological assessment, apoptosis, alveolar wall count (AWC), vena centralis count (VCC) were included. Results: Statistical significance was found in the pulmonary tissue values of tGSH on behalf of NPRF, and MDA on behalf of HPRF (p < 0.05). In liver tissue, statistical significance was detected in tGSH and CAT values in favor of NPRF and in MDA, and TNF-α values in favor of HPRF (p < 0.05). Conclusion: Our study has demonstrated that AF protects the pulmonary tissue from the harmful effects of oxygen in the intrauterine period. In addition, our data have suggested that the pulmonary tissue’s being deprived of the useful effects of AF owing to premature birth may be an important trigger in the occurrence of the pulmonary morbidities thought to result from oxygen.
Anahtar Kelime: Amniotic fluid hyperbaric oxygen oxidative stress bronchopulmonary dysplasia

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA korkmaz l, Alan C, Topal İ, tayfur m, Bozkurt A, Gürsul C, Baştuğ O (2023). Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. , 109 - 120. 10.55730/1300-0144.5564
Chicago korkmaz levent,Alan Cumali,Topal İsmail,tayfur mahir,Bozkurt Aliseydi,Gürsul Cebrail,Baştuğ Osman Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. (2023): 109 - 120. 10.55730/1300-0144.5564
MLA korkmaz levent,Alan Cumali,Topal İsmail,tayfur mahir,Bozkurt Aliseydi,Gürsul Cebrail,Baştuğ Osman Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. , 2023, ss.109 - 120. 10.55730/1300-0144.5564
AMA korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. . 2023; 109 - 120. 10.55730/1300-0144.5564
Vancouver korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. . 2023; 109 - 120. 10.55730/1300-0144.5564
IEEE korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O "Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?." , ss.109 - 120, 2023. 10.55730/1300-0144.5564
ISNAD korkmaz, levent vd. "Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?". (2023), 109-120. https://doi.org/10.55730/1300-0144.5564
APA korkmaz l, Alan C, Topal İ, tayfur m, Bozkurt A, Gürsul C, Baştuğ O (2023). Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. Turkish Journal of Medical Sciences, 53(1), 109 - 120. 10.55730/1300-0144.5564
Chicago korkmaz levent,Alan Cumali,Topal İsmail,tayfur mahir,Bozkurt Aliseydi,Gürsul Cebrail,Baştuğ Osman Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. Turkish Journal of Medical Sciences 53, no.1 (2023): 109 - 120. 10.55730/1300-0144.5564
MLA korkmaz levent,Alan Cumali,Topal İsmail,tayfur mahir,Bozkurt Aliseydi,Gürsul Cebrail,Baştuğ Osman Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.109 - 120. 10.55730/1300-0144.5564
AMA korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. Turkish Journal of Medical Sciences. 2023; 53(1): 109 - 120. 10.55730/1300-0144.5564
Vancouver korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?. Turkish Journal of Medical Sciences. 2023; 53(1): 109 - 120. 10.55730/1300-0144.5564
IEEE korkmaz l,Alan C,Topal İ,tayfur m,Bozkurt A,Gürsul C,Baştuğ O "Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?." Turkish Journal of Medical Sciences, 53, ss.109 - 120, 2023. 10.55730/1300-0144.5564
ISNAD korkmaz, levent vd. "Can amniotic fluid protect developing fetal lungs against the harmful effects of oxidative stress?". Turkish Journal of Medical Sciences 53/1 (2023), 109-120. https://doi.org/10.55730/1300-0144.5564
Sayfa Oluşturulma Tarihi
24-04-2024 6:12

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