Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 160 - 170 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5569 İndeks Tarihi: 24-03-2023

Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma

Öz:
Background/aim: Advanced glycation end products receptor (RAGE) is a pattern recognition receptor which attracted attention in chronic airway diseases recently. This study aimed to determine the association of RAGE with asthma and the cellular responses resulting from RAGE signaling pathway activation. Materials and methods: Asthmatic (n = 362) and healthy (n = 134) children were genotyped by PCR-RFLP. Plasma sRAGE levels were determined by ELISA. Lung structural cells were stimulated with AGEs (advanced glycation end products) and control BSA. Expressions of cytokines and protein levels were determined by real-time PCR and ELISA. Results: Gly82Ser and –374 T/A polymorphisms in RAGE gene were associated with lower plasma sRAGE levels (p < 0.001 and p < 0.025, respectively). AGE stimulation increased the expression of RAGE (p = 0.002), ICAM-1 (p = 0.010) and VCAM-1 (p = 0.002) in endothelial cells; TIMP-1 (p = 0.003) and MCP-1 (p = 0.005) in fibroblasts. AGE stimulation increased protein levels of IL-6 (p < 0.001) in endothelial cells; VEGF (p = 0.025) and IL-8 (p < 0.001) in fibroblasts; IL-1b (p < 0.001) and VEGF (p = 0.007) in epithelial cells. Conclusion: Activation of RAGE pathway may contribute to asthma pathogenesis by increasing the expression of several asthma- related genes. These findings suggest that suppression of RAGE signaling may be an alternative candidate for treating asthma.
Anahtar Kelime: Asthma airway cells angiogenesis RAGE remodeling

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA BİRBEN E, SAHINER U (2023). Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. , 160 - 170. 10.55730/1300-0144.5569
Chicago BİRBEN ESRA,SAHINER Umit Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. (2023): 160 - 170. 10.55730/1300-0144.5569
MLA BİRBEN ESRA,SAHINER Umit Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. , 2023, ss.160 - 170. 10.55730/1300-0144.5569
AMA BİRBEN E,SAHINER U Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. . 2023; 160 - 170. 10.55730/1300-0144.5569
Vancouver BİRBEN E,SAHINER U Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. . 2023; 160 - 170. 10.55730/1300-0144.5569
IEEE BİRBEN E,SAHINER U "Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma." , ss.160 - 170, 2023. 10.55730/1300-0144.5569
ISNAD BİRBEN, ESRA - SAHINER, Umit. "Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma". (2023), 160-170. https://doi.org/10.55730/1300-0144.5569
APA BİRBEN E, SAHINER U (2023). Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turkish Journal of Medical Sciences, 53(1), 160 - 170. 10.55730/1300-0144.5569
Chicago BİRBEN ESRA,SAHINER Umit Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turkish Journal of Medical Sciences 53, no.1 (2023): 160 - 170. 10.55730/1300-0144.5569
MLA BİRBEN ESRA,SAHINER Umit Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.160 - 170. 10.55730/1300-0144.5569
AMA BİRBEN E,SAHINER U Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turkish Journal of Medical Sciences. 2023; 53(1): 160 - 170. 10.55730/1300-0144.5569
Vancouver BİRBEN E,SAHINER U Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turkish Journal of Medical Sciences. 2023; 53(1): 160 - 170. 10.55730/1300-0144.5569
IEEE BİRBEN E,SAHINER U "Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma." Turkish Journal of Medical Sciences, 53, ss.160 - 170, 2023. 10.55730/1300-0144.5569
ISNAD BİRBEN, ESRA - SAHINER, Umit. "Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma". Turkish Journal of Medical Sciences 53/1 (2023), 160-170. https://doi.org/10.55730/1300-0144.5569