Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 171 - 182 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5570 İndeks Tarihi: 24-03-2023

Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study

Öz:
Background/aim: In this prospective observational study, we aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy. Materials and methods: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021. Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery room, T1: 1st hour in the ward, T2: 6th hour, T3: 12th hour, and T4: 24th hour). Results: Postoperative VAS pain scores were similar in the vitamin D deficient group at all time points (T0-4), but differed significantly only at the T-0 time point (p = 0.020). The mean cumulative tramadol consumption was significantly higher in the vitamin D deficiency group than in the nondeficiency group (p = 0.005). Vitamin D levels were lower in patients with VAS ≥ 4 at the postoperative T-0 time point (p = 0.009). In the multivariate linear regression analysis, 15.7% of cumulative tramadol consumption was due to vitamin D deficiency (β = –0.188). Conclusion: Our study shows that preoperative low vitamin D level was associated with an increase in acute postoperative pain scores and consumption of opioid analgesics in patients undergoing laparoscopic cholecystectomy. Our findings may be useful for postoperative pain management in patients with vitamin D deficiency.
Anahtar Kelime: Vitamin D vitamin D deficiency postoperative pain analgesia laparoscopy

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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  • 1. Wills VL, Hunt DR. Pain after laparoscopic cholecystectomy. British Journal of Surgery 2000; 87: 273-284. https://doi. org/10.1046/j.1365-2168.2000.01374.x
  • 2. Ahiskalioglu EO, Ahiskalioglu A, Aydin P, Yayik AM, Temiz A. Effects of single-dose preemptive intravenous ibuprofen on postoperative opioid consumption and acute pain after laparoscopic cholecystectomy. Medicine 2017; 96 (8): 1–5. https://doi.org/10.1097/MD.0000000000006200
  • 3. Amrein K, Scherkl M, Hoffmann M. Vitamin D deficiency 2.0: an update on the current status worldwide. European Journal of Clinical Nutrition 2020; 74 (11): 1498–1513. https://doi. org/10.1038/s41430-020-0558-y
  • 4. Marcinowska-Suchowierska EB, Talalaj MJ, kłodarczyk AW, Bielecki K, Zawadzki JJ et al. Calcium/phosphate/vitamin D homeostasis and bone mass in patients after gastrectomy, vagotomy, and cholecystectomy. World Journal of Surgery 1995; 19 (4): 597–601. https://doi.org/10.3389/fendo.2021.657488
  • 5. Shabanzadeh DM, Jørgensen T, Linneberg A, Sørensen LT, Skaaby T. Vitamin D and gallstone disease-A population- based study. Endocrine 2016; 54 (3): 818–825. https://doi. org/10.1007/s12020-016-1113-4
  • 6. Singla R, Dutta U, Aggarwal N, Bhadada SK, Kochhar R et al. Vitamin-D deficiency is associated with gallbladder stasis among pregnant women. Digestive Diseases and Sciences 2015; 60 (9): 2793–2799. https://doi.org/10.1007/s10620-015- 3678-9
  • 7. Ekiz T, Yeğen SF, Katar MK, Genç Ö, Genç S. 25-Hydroxyvitamin D levels and bone mineral density evaluation in patients with cholecystectomy: a case-control study. Archives of Osteoporosis 2018; 13 (1): 14. https://doi.org/10.1007/s11657- 018-0435-7
  • 8. Polat HB, Beyazal MS. The effect of cholecystectomy on 25-hydroxyvitamin D levels and bone mineral density in postmenopausal women. Archives of Osteoporosis 2018; 13 (1): 7–11. https://doi.org/10.1007/s11657-018-0458-0
  • 9. Kuru P, Akyuz G, Yagci I, Giray E. Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies. Rheumatology International 2015; 35: 315–322. https://doi.org/10.1007/s00296-014-3099-7
  • 10. Song TJ, Chu MK, Sohn JH, Ahn HY, Lee SH et al. Effect of vitamin D deficiency on the frequency of headaches in migraine. Journal of Clinical Neurology 2018; 14: 366–373. https://doi. org/10.3988/jcn.2018.14.3.366
  • 11. Lee A, Chan SKC, Samy W, Chiu CH, Gin T. Effect of hypovitaminosis D on postoperative pain outcomes and short-term health-related quality of life after knee arthroplasty. Medicine 2015; 94: 1812. https://doi.org/10.1097/ MD.0000000000001812
  • 12. Kim Y, Zhang F, Su K, LaRochelle M, Callahan M et al. Perioperative serum 25-hydroxyvitamin D levels as a predictor of postoperative opioid use and opioid use disorder: a cohort study. Journal of General Internal Medicine 2020; 35: 2545– 2552. https://doi.org/10.1007/s11606-020-06001-y
  • 13. Xu HW, Shen B, Hu T, Zhao WD, Wu DS et al. Preoperative vitamin D status and its effects on short-term clinical outcomes in lumbar spine surgery. Journal of Orthopaedic Science 2020; 25: 787–792. https://doi.org/10.1016/j.jos.2019.10.011
  • 14. Tanik N, Balbaloğlu O, Ucar M, Sarp U, Atalay T et al. Does vitamin D deficiency trigger carpal tunnel syndrome? Journal of Back and Musculoskeletal Rehabilitation 2016; 29: 835–839. https://doi.org/10.3233/BMR-160696
  • 15. Bose S, Khanna A, You J, Arora L, Qavi S et al. Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study. Canadian Journal of Anesthesia 2015; 62: 770–776. https://doi. org/10.1007/s12630-015-0357-4
  • 16. Turan A, Hesler BD, You J, Saager L, Grady M et al. The association of serum vitamin D concentration with serious complications after noncardiac surgery. Anesthesia and Analgesia 2014; 119: 603–612. https://doi.org/10.1213/ANE.0000000000000096
  • 17. Cigerli O, Parildar H, Unal AD, Tarcin O, Erdal R et al. Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey. Public Health Nutrition 2013; 16: 1306–1313. https://doi.org/10.1017/ S1368980012003588
  • 18. Shipton EA, Shipton EE. Vitamin D and pain: Vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Research and Treatment 2015; 4: 1-12. https://doi.org/10.1155/2015/904967
  • 19. Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. International Journal of Molecular Sciences 2017; 18: 1–9. https://doi.org/10.3390/ijms18102170
  • 20. Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. The association between Vitamin D concentration and pain: A systematic review and meta-analysis. Victorian Literature and Culture 2018; 21: 2022–2037. https://doi.org/10.1017/ S1368980018000551
  • 21. Shipton EE, Shipton EA. Vitamin D deficiency and pain: clinical evidence of low levels of vitamin D and supplementation in chronic pain states. Pain and Therapy 2015; 4 (1): 67–87. https://doi.org/10.1007/s40122-015-0036-8
  • 22. Donnally CJ, Sheu JI, Bondar KJ, Mouhanna JN, Li DJ et al. Is there a correlation between preoperative or postoperative vitamin D levels with pseudarthrosis, hardware failure, and revisions after lumbar spine fusion?. World Neurosurgery 2019; 130: 431–437. https://doi.org/10.1016/j.wneu.2019.06.109
  • 23. Bergman P, Sperneder S, Höijer J, Bergqvist J, Björkhem- Bergman L. Low vitamin D levels are associated with higher opioid dose in palliative cancer patients-results from an observational study in Sweden. PLoS One 2015; 10: 1–11. https://doi.org/10.1371/journal.pone.0128223
  • 24. Straube S, Derry S, Straube C, Moore RA. Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database of Systematic Reviews 2015; 1: CD007771. https:// doi.org/10.1002/14651858.CD007771.pub2
  • 25. Helde-Frankling M, Bergqvist J, Klasson C, Nordström M, Höijer J et al. Vitamin D supplementation to palliative cancer patients: protocol of a double-blind, randomised controlled trial. BMJ Supportive and Palliative Care 2017; 7: 458–463. https://doi.org/10.1136/bmjspcare-2017-001429
  • 26. Yang MMH, Hartley RL, Leung AA, Ronksley PE, Jetté N et al. Preoperative predictors of poor acute postoperative pain control: a systematic review and meta-analysis. BMJ Open 2019; 9 (4): e025091. https://doi.org/10.1136/bmjopen-2018-025091
  • 27. Grodofsky SR, Sinha AC. The association of gender and body mass index with postoperative pain scores when undergoing ankle fracture surgery. Journal of Anaesthesiology Clinical Pharmacology 2014; 30: 248–252. https://doi. org/10.4103/0970-9185.130041
APA Miniksar Ö, yüksek a, göçmen a, katar m, Kılıç M, Honca M (2023). Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. , 171 - 182. 10.55730/1300-0144.5570
Chicago Miniksar Ökkeş Hakan,yüksek ahmet,göçmen ayşe yeşim,katar mehmet kağan,Kılıç Mahmut,Honca Mehtap Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. (2023): 171 - 182. 10.55730/1300-0144.5570
MLA Miniksar Ökkeş Hakan,yüksek ahmet,göçmen ayşe yeşim,katar mehmet kağan,Kılıç Mahmut,Honca Mehtap Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. , 2023, ss.171 - 182. 10.55730/1300-0144.5570
AMA Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. . 2023; 171 - 182. 10.55730/1300-0144.5570
Vancouver Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. . 2023; 171 - 182. 10.55730/1300-0144.5570
IEEE Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M "Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study." , ss.171 - 182, 2023. 10.55730/1300-0144.5570
ISNAD Miniksar, Ökkeş Hakan vd. "Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study". (2023), 171-182. https://doi.org/10.55730/1300-0144.5570
APA Miniksar Ö, yüksek a, göçmen a, katar m, Kılıç M, Honca M (2023). Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. Turkish Journal of Medical Sciences, 53(1), 171 - 182. 10.55730/1300-0144.5570
Chicago Miniksar Ökkeş Hakan,yüksek ahmet,göçmen ayşe yeşim,katar mehmet kağan,Kılıç Mahmut,Honca Mehtap Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. Turkish Journal of Medical Sciences 53, no.1 (2023): 171 - 182. 10.55730/1300-0144.5570
MLA Miniksar Ökkeş Hakan,yüksek ahmet,göçmen ayşe yeşim,katar mehmet kağan,Kılıç Mahmut,Honca Mehtap Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.171 - 182. 10.55730/1300-0144.5570
AMA Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. Turkish Journal of Medical Sciences. 2023; 53(1): 171 - 182. 10.55730/1300-0144.5570
Vancouver Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study. Turkish Journal of Medical Sciences. 2023; 53(1): 171 - 182. 10.55730/1300-0144.5570
IEEE Miniksar Ö,yüksek a,göçmen a,katar m,Kılıç M,Honca M "Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study." Turkish Journal of Medical Sciences, 53, ss.171 - 182, 2023. 10.55730/1300-0144.5570
ISNAD Miniksar, Ökkeş Hakan vd. "Serum vitamin D levels are associated with acute postoperative pain and opioid analgesic consumption after laparoscopic cholecystectomy: a strobe compliant prospective observational study". Turkish Journal of Medical Sciences 53/1 (2023), 171-182. https://doi.org/10.55730/1300-0144.5570